DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and notch3

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_571624.2	Gene:	notch3 / 58066	ZFINID:	ZDB-GENE-000329-5	Length:	2468	Species:	Danio rerio

Alignment Length:	711	Identity:	149/711 - (20%)
Similarity:	205/711 - (28%)	Gaps:	286/711 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  2267 RLNGIVLMHREEIEKDVGINITMVGIDECLYENQMCEGSCTNSL--------------------- 2310
            :|||.....|:....    |:..|.|:||.....:.:|:|.:.:
Zfish   726 QLNGFTCKCRQGFRG----NLCQVNINECASSPCLNQGTCVDGVASFTCLCEPPYSGPTCAELLT 786

  Fly  2311 EISPLPYMVNANKTALVGVRVDTIADCTCGARNFTKP-----------ESCRTTPCHNGGRCVDT 2364
            ..||.|.   ||..:.|.........|.|      :|           ..|.:.||.|.|.|.:|
Zfish   787 PCSPNPC---ANHASCVHTPDYLGYQCNC------QPGWQGHLCNNDINECTSNPCKNRGTCTNT 842

  Fly  2365 RFGPHCSCPVGYTGPRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYNGPIVPP 2429
            ..|..|||..|||||.|
Zfish   843 LGGYVCSCRAGYTGPNC------------------------------------------------ 859

  Fly  2430 ERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFWDTESIRMVVDFC 2494
               ||.|:|.        .|...::.||.|            ||          ..|.|     |
Zfish   860 ---ETDINDC--------SPNPCLNGGSCT------------DG----------VNSFR-----C 886

  Fly  2495 KSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGLYREQFDQSLYFWHYMPTAK- 2558
            ...          |.|....|...     .||..:|  |.:.||...:      |...|..|.|
Zfish   887 SCL----------PGFTGARCATE-----LNECQSV--PCKNGGTCTD------YVNSYTCTCKP 928

  Fly  2559 GFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCAQTETTARCWEHGNCVGSLSEARCHCR 2623
            ||.|.                 |...:|..|           |.:.|:..|.|...::..:|.||
Zfish   929 GFTGL-----------------LCETNVPDC-----------TESSCFNGGTCTDGINGFKCTCR 965

  Fly  2624 PGWTGPACNIPTIPTTFKAQSYVKYALSFEPDRFSTQVQLRFRTREEYGELFRVSDQHNREYGIL 2688
            .|:||..|                   .:|.:...:|..|.....::..|.:|.|
Zfish   966 TGFTGDYC-------------------QYEVNECDSQPCLNGGICQDAMESYRCS---------- 1001

  Fly  2689 EIKDGHLHFRYNL------------NSLRTEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLELDG 2741
             ...|:...|...            |..|..:||.......:  |.|.    .||.....:..:.
Zfish  1002 -CPKGYTGPRCQYPVDWCRPSNPCKNGGRCRQKDASFTCDCL--GGWS----GRYCDIPGVSCEV 1059

  Fly  2742 GEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKSCLDDIRLEGKHLPLPP 2806
            ...:|..:|.|...|....|:.....|....|:|||        .|.:|..|       |....|
Zfish  1060 AARQRGRQTDELCLHGGHCVNTGNTHYCKCPADYTG--------SYCESQFD-------HCEEKP 1109

  Fly  2807 AMNG----TQWGQATM-------ARNLEK---GCPSNKPCSNVICPDPFECVDLWNVYECTCGEG 2857
            .:||    :..|..|.       ..|.|:   .|.|: ||.|     ...|:||...|.|:|
Zfish  1110 CLNGATCRSYMGGFTCDCMPGYEGNNCEREVNECQSH-PCQN-----GGTCIDLVGHYICSC--- 1165

  Fly  2858 RIMSPDSKGCM---DRNECL------DMP-CMNGATCINLEPRL-RYRCICPDGFWGENCE 2907
               .|.:.|.:   :.::|.      .|| |.|..||::   |: .|||.||.||.||.||
Zfish  1166 ---PPGTLGVLCEINEDDCATPSWPRGMPKCQNNGTCVD---RVGGYRCNCPPGFTGERCE 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	15/29 (52%)
		LamG	2385..2570	CDD:238058	29/185 (16%)
		EGF_2	<2605..2631	CDD:285248	9/25 (36%)
		Laminin_G_2	2665..2800	CDD:280389	26/146 (18%)
		EGF_CA	2869..2907	CDD:238011	17/45 (38%)
		Cadherin_C	2952..3088	CDD:279398
notch3	NP_571624.2	EGF_CA	97..131	CDD:238011
		EGF_CA	134..171	CDD:238011
		EGF_CA	212..247	CDD:238011
		EGF_CA	250..287	CDD:238011
		EGF_CA	290..325	CDD:238011
		EGF_CA	367..405	CDD:238011
		EGF_CA	407..443	CDD:238011
		EGF_CA	445..481	CDD:238011
		EGF_CA	483..519	CDD:238011
		EGF_CA	521..556	CDD:238011
		EGF_CA	560..594	CDD:238011
		EGF_CA	596..631	CDD:238011
		EGF_CA	634..668	CDD:238011
		EGF_CA	672..705	CDD:238011
		EGF_CA	708..744	CDD:238011	5/21 (24%)
		EGF_CA	746..781	CDD:238011	5/34 (15%)
		EGF_CA	824..860	CDD:238011	17/86 (20%)
		EGF_CA	862..897	CDD:238011	13/79 (16%)
		EGF_CA	902..936	CDD:238011	14/58 (24%)
		EGF_CA	938..974	CDD:238011	13/65 (20%)
		EGF_CA	977..1012	CDD:238011	7/45 (16%)
		EGF_CA	1015..1050	CDD:238011	7/40 (18%)
		EGF_CA	1103..1137	CDD:238011	8/40 (20%)
		EGF_CA	1140..1175	CDD:238011	13/46 (28%)
		EGF_CA	<1193..1220	CDD:238011	14/29 (48%)
		EGF_CA	1222..1260	CDD:238011
		Notch	1392..1423	CDD:278494
		Notch	1429..1462	CDD:278494
		Notch	1475..1502	CDD:278494
		NOD	1508..1559	CDD:284282
		NODP	1577..1634	CDD:284987
		ANKYR	<1784..1896	CDD:223738
		ANK	<1784..1895	CDD:238125
		ANK repeat	1791..1839	CDD:293786
		ANK repeat	1841..1872	CDD:293786
		Ank_5	1861..1916	CDD:290568
		ANK	1869..1995	CDD:238125
		ANK repeat	1875..1906	CDD:293786
		ANK repeat	1908..1939	CDD:293786
		Ank_2	1913..2005	CDD:289560
		ANK	1936..2057	CDD:238125
		ANK repeat	1941..1972	CDD:293786
		ANK repeat	1974..2005	CDD:293786
		Ank_2	1979..>2039	CDD:289560
		Amelogenin	2232..2325	CDD:197891
		DUF3454	2384..2445	CDD:288764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910