DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and cntnap1

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:XP_694580.5 Gene:cntnap1 / 566220 ZFINID:ZDB-GENE-030916-2 Length:1309 Species:Danio rerio


Alignment Length:1380 Identity:253/1380 - (18%)
Similarity:409/1380 - (29%) Gaps:485/1380 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1767 PILTVTVHDEDETNKFQYKVIDNSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQ 1831
            |:...:.|.....|.|         |.|....:..::..:.|.:..||....|.    |.::||.
Zfish    31 PLYASSFHASSRYNFF---------YSAHFAKLYGSSGWSPSTRDRQPWMQIDL----GRKYRIM 82

  Fly  1832 -VNDKGEDNDND---KYHVAY-----SWVVVKLRDINDNKP-HFERANVEVSVF----------- 1875
             :..:|..|..|   ||.|.|     ||....::..|...| ::....|:.:||           
Zfish    83 AIATQGTFNSYDWVTKYMVLYGDRFDSWTPYVMKGGNMTLPGNWNYYQVKRNVFHYAFTAKHLRI 147

  Fly  1876 --------EDTKVGTELEKFKATDPDQ-----GGKSKVSYSIDRSSDR--QRQFAIN-------- 1917
                    ...|:|..:| |.....|.     .|...|:||..|...|  |..:|:|        
Zfish   148 YPMGWNTENGGKIGLRVE-FYGCPYDSYVMNFEGDDMVAYSFPRGRMRTLQDHYALNFKTLEKDG 211

  Fly  1918 --------QNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDY 1974
                    |..|:|::....|        ..|.|..||.          .|.:.|......|.:.
Zfish   212 ILLHSEGLQGDSITLELKTGR--------LYLHISLGSS----------TVHNTNGMTTMMLGNL 258

  Fly  1975 RPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVI 2039
            ......|     .|.|         |..|....|.||...:..|            .||:     
Zfish   259 LDTQHWH-----YVTI---------KRFGRELNFTLDSQTETTI------------LNGE----- 292

  Fly  2040 SSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTL-----TVIIGDVNDNKMQPGSKDIFVYNYQG 2099
              .:..|.: :|.|:..::.||  .|.:.|....     .|.|..:|           .:|..|.
Zfish   293 --FQHLDLD-KKIYVGGVIEKD--MPHLPGKVNFRGCMENVFINGIN-----------IIYMTQN 341

  Fly  2100 QSPDTPI------------------------------------GRVYV-YDLDDWDLPDKKFYWE 2127
            |.|:..:                                    .|:.| :....||      |..
Zfish   342 QEPEIRLAPKKKKMHYMCRDLLWKPMTFAGPNNYLQLPGFFRKNRLAVKFKFRSWD------YTG 400

  Fly  2128 AMEHPRFK---------LDEDSGMVT-MRAGTREGRYHLRFKVYDRKHTQTDIPAN---VTVTVR 2179
            .:...||.         |.|....|| |:.|.:..|:...:::.|......|:.|.   :|:|:.
Zfish   401 LLMFTRFADELGSLELGLSEGQVNVTLMQPGNKRLRFAAGYRLNDGFWHTVDLTAKDNLLTITID 465

  Fly  2180 E-------IPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSR--SKMDRFRDKLADLLNTEREN 2235
            |       |.:..:|.:|.....|...         :|.:.:|  :|:.||...:..:. .:.|.
Zfish   466 EDESSPLKITNPFMVRTGDRYFFGGCP---------KTNNTARCVTKLSRFHGCMQQIF-IDDEP 520

  Fly  2236 VDIFSVQLKRKHPPLTDVRFS---------------------------------------AHGSP 2261
            ||| .|.|:||.....::...                                       .|.|.
Zfish   521 VDI-DVMLQRKWGRYAEILLGTCGITDRCSPNPCEHEGRCIQSWNDFLCVCNNTGYKGEVCHNSV 584

  Fly  2262 Y---YKPVRLNGIVLMHREEIEKDVG------------INITMVGIDECLYENQMCEGSCTNSLE 2311
            |   .:..||||........|:.|:.            :..|...|:....::....||..:...
Zfish   585 YRESCEAYRLNGKYWSGNYTIDPDLSGPLKPFTVYCNMLQKTWTVIEHNRMKSTKVSGSTIDRPY 649

  Fly  2312 ISPLPYMVNAN---KTALVGVRV--DTIADCTC------------------GARNFTK------- 2346
            |..:.| |||:   .|||....:  :...:.:|                  |..|.:.       
Zfish   650 IGDVQY-VNASWDEVTALANTSLYCEQWIEFSCYKSRLLNTPHGRPYTYWIGRHNESHEYWGGAF 713

  Fly  2347 PESCRTTPCHNGGRCVDTRFGPHCSCPVGY----------------------------TGPRCQQ 2383
            |||.: ..|.....|.|:::  .|:|...|                            ||...|.
Zfish   714 PESGK-CGCAVNQTCTDSKY--WCNCDADYRQWHSDKGYLSFRDHLPIRRLVIGDTNRTGSEAQY 775

  Fly  2384 TTRSF--RGNGWAW------------YPPLEMCDESHLSLEFITRKPDGLIIYNGPIVPPERDET 2434
            :..:.  .|:...|            :|..:....:.::..|.|.:..|:.:        |..:.
Zfish   776 SVGALYCHGDRSIWNTIAFTKPTYLTFPTFKPGTSADITFHFRTYRTYGVFV--------EASDD 832

  Fly  2435 LISDFIALELERGYPRLLIDF-GSGTLELRVKTKKTLDDGEWHRIDLFWDTESIRMVVDFCKSAE 2498
            .:.:|:.:||......:.|.. |.|...:.:::.|.|:|.|||.::...:.:..|:.|||     
Zfish   833 HLRNFLRVELNSTTEVVFIFMVGDGIRNVTLRSPKALNDNEWHYVEAEINVKLARLKVDF----- 892

  Fly  2499 IAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVN--APLQVGGLYREQFDQSLYFWHYMPTAKGFD 2561
                   .||.....         |...|:.::  .||.||....              |.:.|.
Zfish   893 -------LPPAIHKF---------PGQTYITMDFTQPLLVGAANH--------------TLRPFL 927

  Fly  2562 GCIRNLVHNSKLYDL-----AHPGLSRNSVAGCPQTEEVCAQTETTARCWEHGNCVGSLSEARCH 2621
            ||:|.|..|....||     ...|:.||....|         ...:..|...|.|:...:...|.
Zfish   928 GCLRGLRMNGVPVDLEGKVDESAGIRRNCTGAC---------LNASIPCRNGGQCIDGYASYACD 983

  Fly  2622 C-RPGWTGPACNIPTIPTTFKAQSYVKYALSFEPDRF-----------------------STQVQ 2662
            | ..|:.|..|:: .|...|...::::|.:..||..|                       :..::
Zfish   984 CNNTGFDGYYCHL-DIGAFFDVGAWLRYDVRKEPISFDAWWANFWIEPHWHNFTLGYNTTTDDIE 1047

  Fly  2663 LRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVVK 2727
            ..|.|.:....|..:|...|....:|..|||.|..||.|..:..:.|....|   :.||..|.|.
Zfish  1048 FSFSTLQAPAVLLYISSFSNDYIAVLLKKDGTLSMRYRLGIISYKFKMTDRN---MADGFPHFVN 1109

  Fly  2728 VNRYGSAATLELD----------GGEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAEYTGVRTFE 2782
            :.|:......::|          .||..|:              |..:.::.|...|..||    
Zfish  1110 ITRHNYTVWTQVDYMDPWIEKLVPGEIPRF--------------DSPKSIFLGRVMEVGGV---- 1156

  Fly  2783 VYADYQ---------KSCLDDIR------LEGKHLPLPPAMNGTQWGQATMARNLEKGCPSNKPC 2832
               ||:         ..|:..:|      |:....|     |.|.....|....:|..|.:..|.
Zfish  1157 ---DYEIQRHNSPGFMGCISGVRYNIFAPLKAYFRP-----NVTNPPVTTQGYVVESNCGAFPPV 1213

  Fly  2833 SNVICPDPFECVDLW 2847
            ...:   |:| .|.|
Zfish  1214 LGYV---PWE-DDPW 1224

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637
Cadherin_repeat 1083..1166 CDD:206637
Cadherin_repeat <1219..1298 CDD:206637
Cadherin_repeat 1310..1414 CDD:206637
Cadherin_repeat 1423..1514 CDD:206637
Cadherin_repeat 1522..1630 CDD:206637
Cadherin_repeat 1638..1741 CDD:206637
Cadherin_repeat 1762..1861 CDD:206637 23/102 (23%)
Cadherin_repeat 1871..1966 CDD:206637 26/136 (19%)
Cadherin_repeat 1974..2083 CDD:206637 21/113 (19%)
EGF 2350..2380 CDD:278437 8/57 (14%)
LamG 2385..2570 CDD:238058 37/201 (18%)
EGF_2 <2605..2631 CDD:285248 7/26 (27%)
Laminin_G_2 2665..2800 CDD:280389 34/159 (21%)
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
cntnap1XP_694580.5 FA58C 23..169 CDD:214572 31/151 (21%)
FA58C 38..168 CDD:238014 30/143 (21%)
Laminin_G_2 204..333 CDD:280389 31/182 (17%)
LamG 366..517 CDD:238058 29/166 (17%)
EGF 548..578 CDD:278437 0/29 (0%)
FReD 588..>632 CDD:294064 8/43 (19%)
LamG 791..936 CDD:238058 35/187 (19%)
EGF_CA 960..994 CDD:238011 8/42 (19%)
Laminin_G_2 1050..1178 CDD:280389 33/151 (22%)
4.1m 1260..1278 CDD:128590
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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