DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and hspg2

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:XP_021325650.1 Gene:hspg2 / 565429 ZFINID:ZDB-GENE-080807-4 Length:3701 Species:Danio rerio


Alignment Length:2819 Identity:515/2819 - (18%)
Similarity:873/2819 - (30%) Gaps:1076/2819 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   507 DFWVIITNM---------------GHNAGIKYTDNQRVIILVKDVNDEPPYFINRPLPMQAVVQL 556
            :.|.||||.               .|::..: ..|...:..|:|    |.:......|::|    
Zfish  1424 EIWEIITNFSNGQSSFPFSSSSQSSHSSSFE-AQNSLSLSSVRD----PSFHSGLTSPLKA---- 1479

  Fly   557 NAPPNTPVFTLQARDPDTDHNIHYFIVRDRTGGRFEVDERSGVVR-TRGTDLFQLDMEYVLYVKA 620
                      .::...|..|:.|    .|.|.   :|::...::. .||......:...::|   
Zfish  1480 ----------SESHSSDPAHSSH----PDSTQ---QVEQEKNIIGVVRGPRPVPSNKYVLVY--- 1524

  Fly   621 EDQNG---KVDDRRFQSTPE----ERLSIVGGKRAPQFYMPSYEAEIPENQKKDSDI------IS 672
               ||   ..||..|...||    |::...|||..   |..||......:..:|:|:      |:
Zfish  1525 ---NGFSLHPDDVLFWQLPEPFKGEKVGAYGGKLK---YTISYVPGPRGSPIEDADVQIIGNDIT 1583

  Fly   673 IKAKSFADREIRYTLKAQGQGAGTFNIGPTSGIVKLAKELDFEDL-RQPH-----------VYSL 725
            :.|:....|         |.||              .:..|||.: |:.|           .:.:
Zfish  1584 LVARQIWQR---------GHGA--------------RESQDFEIVFREEHWQRPDGMPATREHLM 1625

  Fly   726 IVTATEDSGGFSTSVDLTIRVTDVNDNAPKFELPDY----QAHNVDE-DIPLGTSILRVKAMDSD 785
            :|.|..|......|....:|.:.::.......:|:|    ||..|:: ..|.|.|.|  ...|..
Zfish  1626 MVLADLDDILIRASYHTEMRSSSISGVHMDVAVPEYTSLAQALEVEQCQCPPGYSGL--SCQDCA 1688

  Fly   786 SGSNAEIEYLVSDDHFAVDSNGIIVNNKQLDADNNNAYYEFIVTAKDKGEPPKSGVAT-VRVYTK 849
            ||             :.....|:.:.:.:....|.::         |... |::|:.| .:..||
Zfish  1689 SG-------------YTRTGGGLYLGHCEPCECNGHS---------DTCH-PETGICTNCQHNTK 1730

  Fly   850 NKNDEE-------------PKFSQQVYTPNVD---------ENAGPNTLVTTVVASDKDG---DN 889
            .:..|:             |:..|....|..|         |:.|......|.......|   :.
Zfish  1731 GELCEQCVDGFFGDPTAGTPEDCQPCACPGTDPENQFSRTCESLGNGGYQCTACQPGYLGQYCER 1795

  Fly   890 VRFGFVGGG------TSSGQFVIEDITGVIRLHNKAISLDKDKYELNVTAMDDGSCCVNGDQTIH 948
            ...|:||..      .|...|:      |::::.:.:.:.:.   |.||.    .|.|:|....:
Zfish  1796 CAPGYVGNPQARVPCRSDAAFL------VVKVYPERVQVAQG---LPVTL----RCQVSGSPPHY 1847

  Fly   949 TSTAVVVVFITDVNDNKPVFKDC-------STYYPKV-------------EEGAPNGSPVIKVVA 993
                    |.....|.:|:....       ..::|.:             ::.:.|.|....|||
Zfish  1848 --------FQWSREDGRPISSSAERRRQGEELHFPGIQSNDAGVYICTCRDQRSSNRSKAEIVVA 1904

  Fly   994 TDEDKGVNGQVKYSIVQQPNQKGTKFTVDEETGEVSTNKVFDREGDDGKFVSVTVKATDQGDPSL 1058
            |...|.:.     ..:::|  |.....|......:.|.|        .|..:.|:..|.:|:..|
Zfish  1905 TLPSKPIE-----VFIEEP--KAQSVRVGSTVSFICTAK--------SKLPAYTLVWTRKGNGKL 1954

  Fly  1059 EG-VCSFTVEITDVNDNPPLFDRQKYVENVK-QDASI----GTNILRVSASDEDADNNGAIVYSL 1117
            .. ...|...:|              ::||: :||.|    |:|:|.:       |...|::|..
Zfish  1955 PNRAMDFNGILT--------------IQNVQPEDAGIYVCTGSNMLGM-------DEGSAVLYVP 1998

  Fly  1118 TAPFNPNDLEYFEIQAESGWIVLKKPLDGCYP-------------RDRYRLRVSASDKGTPA--- 1166
            .|  :.:.:.|...:...|.   :||.:|..|             .|..:.|.:.:...|||   
Zfish  1999 EA--SQSQMFYTAYEMFEGH---RKPAEGVQPVATLSPPVQTVKEGDVAQFRCTVTGNPTPAVEW 2058

  Fly  1167 ---------SAADV---DVELDVVDRNNKPPIWDKSI--------YGPIHIRE--------NVTV 1203
                     |.|.:   .:.:..|||:::.....|::        .|.:|::.        :|.|
Zfish  2059 IGGSGKRISSKAVIRNGQLTISSVDRSDEGEYICKALNTHGEHTARGVLHVQSTGQPNGLPHVQV 2123

  Fly  1204 GTVVTSVKASSGIE------GNPTVFYR------LMPGSTAQTNKFHTF-------------YLQ 1243
            ......:.....:.      |:||...:      .:|.....::.||.|             .||
Zfish  2124 SPQRVEIYEGETLRLYCRAIGSPTPSLKWNKRGGSLPPQAIPSHGFHQFKSNSLDVLQRRIEELQ 2188

  Fly  1244 QRPDNGDTWADIKVNHPLDYESIKEYNLTIRVENNGAQQLASEATVYIMLEDVNDEIPLFTEREQ 1308
            .|.|..|....:..|..|     .:....:.|..|.|.  :|||.:.:.:            .:.
Zfish  2189 ARMDRTDIGTLVVPNIRL-----SDAGTYLCVGTNAAG--SSEAHIDVSV------------TKG 2234

  Fly  1309 ETVLEG---EPIGTKVTQVNAIDKDGTFP---NNQVYYYIVDSPRNEGKEFFEINLQSGEIFTKT 1367
            |.:|.|   :|....|.:..|:|.:...|   ...|.:.......:...:..|..|:   |...:
Zfish  2235 ENILSGVIIQPPSASVIEGEALDLNCLVPGTSTGSVKWSRAGGLLSSNHQVLETRLR---ILRAS 2296

  Fly  1368 VFDREKKGAYALEVEARDGAPSARPNSNGPN--------SVTKFIRIGIADKNDNPPYFDKSLYE 1424
            ..|   .|.|...||            |||:        |||....:|:     ..|......:.
Zfish  2297 ADD---TGDYICTVE------------NGPSPQKATVSVSVTSSASLGL-----QTPIISIEPHS 2341

  Fly  1425 AEVDENEDIQHTVLTVTAKDHD--ESSRIRYEITSG-------NIGGAFAVKNMTGAIYVAGALD 1480
            |.|.:.|.     .:...|.|:  :..|:.:::|:.       .:|...::..:|.|        
Zfish  2342 AVVKQGES-----ASFRCKVHNGAQPVRLEWKLTNNLPLPDNVKVGPDSSIMTVTNA-------- 2393

  Fly  1481 YETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTYRTQITEEDDRNLPKRVLQVTAT 1545
             :.:.:...|..||:.....::.|.:.|:   ::|.....|....::...|..||..:.      
Zfish  2394 -QAKNQGTYRCVASNLYGMTHSIVSLIVR---ESPKAVVTPAGPVRVRVGDPINLECQA------ 2448

  Fly  1546 DGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQDEG 1610
             ..:.||....:.|       ||  |.|..::.|.       |:|..                  
Zfish  2449 -AGEPRPSVRWHRL-------DN--NRKTMLSSTV-------PVDSS------------------ 2478

  Fly  1611 GEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTEN-GTAGMVVMTMTAVDYDDPNEGSNARLVY 1674
                   |.:||.:....|:      |.|..:...| ||      |.|.|:              
Zfish  2479 -------AIIQVLVARPEDS------GTYVCSAQNNQGT------TETRVE-------------- 2510

  Fly  1675 SIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVKDI 1739
                 |..|  |.|.....|...|           |.|    .::.::|      .||::.. |.
Zfish  2511 -----VFVE--GGPQVPTVPRASV-----------REP----MIIVVEG------STATLHC-DA 2546

  Fly  1740 NDMP-PQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGADKFTMVRNN 1803
            :..| |..|   ||.|     .::||                 :::|::|||        ::..|
Zfish  2547 HGFPKPTIT---WFKE-----RSSLP-----------------WRHKIVDNS--------LILPN 2578

  Fly  1804 DGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERA 1868
            .|.                          .|.|:...|...|:..|.|.:.|.  .|..|:....
Zfish  2579 VGR--------------------------QDSGQYVCNATNHLGTSEVTIMLE--VDTPPYATSL 2615

  Fly  1869 NVEVSV-------------------FEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQF 1914
            ..:|||                   :|.||:...|   .:|...|||..:::.:.:..:...|..
Zfish  2616 PNDVSVRVGEVIRLQCLAHGTPPLRYEWTKINGSL---PSTAQLQGGDLQINLAKENDAGTYRCV 2677

  Fly  1915 AINQNG------SVTIQRSLDREVVPRHQVKILA-----------------------------ID 1944
            |.|:.|      .|:::.||..:|.|:.:||.|.                             |.
Zfish  2678 ASNKVGKSEALAKVSVRSSLSVKVSPQVEVKALGSAVEFTCAAKGGLQIEWLKEGGVLPPNHHIK 2742

  Fly  1945 DG-----------------------------------SPPK----TATATLTVIVQD-------- 1962
            ||                                   :.||    ..|:..||:|.:        
Zfish  2743 DGILRIENLEQSNEGIYTCRVTSQFEHAQDSAKLLIQALPKVKINVRTSVQTVMVGNSVEFECHA 2807

  Fly  1963 INDNAP--KFLKDYRPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVE 2025
            |.|..|  ::.|...| ||:||..|.  .||..|....|.|.    |:|...:.|          
Zfish  2808 IGDPEPTVRWSKVGAP-LPDHVEIRG--NILRIDQVFESDSG----QYRCTATND---------- 2855

  Fly  2026 QDQKGANGDGMAVISSLRSFDR----EQQKEY------MIPIVIKDHGSPAMTGTS--------- 2071
                 ...:...|:.:::|..:    .:.||.      ::|.:...:..|.:|.:.         
Zfish  2856 -----VGSEHSHVVLNIQSLPQIAALPESKEVTIGSDAVLPCIASGYPVPTITWSKVENDLPPKC 2915

  Fly  2072 -----TLTVIIGDVND---------NKMQPGSKDIF--------VYNYQGQSPDTPIGRVYVYDL 2114
                 .|||.:...:|         ||.  |..:.|        |..|..|.|           |
Zfish  2916 RQDGHALTVPVVTESDAGTYVCTAANKQ--GKVEAFTRLNVHERVMPYFTQEP-----------L 2967

  Fly  2115 DDWDLPDKKFYWEAME-----------------------------------------HPRFKLDE 2138
            ....||..|..::|..                                         .|.|:.|.
Zfish  2968 SYLTLPTIKNSYKAFSIKITFRPDNVDGLILYAGMIIYNGQKKTTGADFISFGLLGGRPEFRFDV 3032

  Fly  2139 DSGMVTMRAGT--REGRYHLRFKVYDRKHTQTDIPANVTVTVREIPHEAVVNSGSVRLSGISDED 2201
            .|||.|:|..|  :.|.:| ...:| |..||                .::|..|...::|.|...
Zfish  3033 GSGMATIRYPTPIKLGEFH-TVHLY-RNQTQ----------------GSLVVDGQAPVNGTSQGK 3079

  Fly  2202 FIRVWNYRTQSMSRSKMDRFRDKLADLLNTERENVDIFSVQLKRKHPPLTDVRFSAHGSPYYKPV 2266
            |                     |..||      |.::|                 ..|.|.|..:
Zfish  3080 F---------------------KGLDL------NEELF-----------------VGGYPNYSML 3100

  Fly  2267 R------------LNGIVLMHREEIEKDVGINITMVGIDEC-LYENQMC--EGSCTNSLEISPLP 2316
            .            :..:::...|.|.||:..:.|  |:..| ..:::.|  :|:|.:|       
Zfish  3101 AKTAGLKTGFVGCIKQLIIQGDEVIFKDLDKSST--GVSNCPTCKDRPCQNDGTCEDS------- 3156

  Fly  2317 YMVNANKTALVGVRVDTIADCTCGARNFTKPE-------SCRTTPCHNGGRCVD--TRFGPHCSC 2372
                          |.::..||| .|.||...       .|.|..|.....|::  :..|..|.|
Zfish  3157 --------------VASLYKCTC-KRGFTGSNCQHHSSLHCHTEACGPDATCINRPSGLGYDCRC 3206

  Fly  2373 PVGYTGPRCQQ----TTRSFRG-NGWAWYPPL-EMCDESHLSLEFITRKPDGLIIYNGPIVPPER 2431
            .:|.:|.:|..    ||..|.| :.:..|||| .:.::..:.:||....||||:.::|      .
Zfish  3207 HLGKSGNKCMDGTLITTPLFDGEDSYIAYPPLTNIHNDLRIEMEFKPMDPDGLMFFSG------G 3265

  Fly  2432 DETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFWDTESIRMVVDFCKS 2496
            .:..:.||:|:.:..|:.....:.|:|...||.:...:||  :|||:......:...:.||..| 
Zfish  3266 KKMKVEDFVAVSMVNGHVEFRYELGTGQAVLRSQEPVSLD--QWHRVVAERLNKDGSLTVDHAK- 3327

  Fly  2497 AEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGLYREQFDQSLYFWHYMPTAKG-- 2559
             ||.....|          :|:|        ||::.|:.:||:  ...|       .:|....  
Zfish  3328 -EITRSSPG----------KAQG--------LNIHTPMYLGGV--PSMD-------ILPKPANVS 3364

  Fly  2560 --FDGCIRNLVHNSKLYDLAHPGLSRNSVAGC----PQTEEVCAQTET----------------- 2601
              |||||..:..|.|..||::......:::.|    |.....|....|                 
Zfish  3365 MLFDGCIGEVFINGKKVDLSYSFTESRAISQCNDDSPCDRRPCLHAGTCMATAEYEYQCFCAEGY 3429

  Fly  2602 --------------TARCWEHGNCVGSLSEARCHCRPGWTGPACNIPTIPTTFKAQ--------- 2643
                          :::|...|:||.:    .|.|..|::|..|.        |.|         
Zfish  3430 EGDRCEIVKESCRHSSQCQNGGSCVNN----HCVCPAGYSGRHCE--------KGQESSFSEAMW 3482

  Fly  2644 ---------SYVKYALSFE----------------PDRFSTQVQLRFRT---------------- 2667
                     |.::|:..|.                ||...| ::|...|                
Zfish  3483 SLEGSGGNDSPIEYSAYFHDNGYLALPKPMFPRSAPDSPET-IELEINTASKDGLILWQGVESAG 3546

  Fly  2668 ----REEYGELFRVSDQ-HNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIV----VNDGQW 2723
                .:::..:..:.|| ..:::..|.:::|||.|.|.|.|...:        ||    |||.||
Zfish  3547 ALNLHKKHANIKELGDQGKGKDFISLGLQNGHLVFSYQLGSGEAQ--------IVSGEPVNDRQW 3603

  Fly  2724 HVVKVNRYGSAATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQ 2788
            |.:...|.|....|::|||..:|.....:.:     :|:.:..:|.||..:...: |...|:...
Zfish  3604 HKITAVRTGKHGYLQIDGGSVQRGQSQGKSI-----MVNTKGNIYLGGAPDMQAL-TGGKYSSGM 3662

  Fly  2789 KSCLDDIRLEGKHLPLPPAMNGTQ 2812
            ..|:       |:|.|..|..|.|
Zfish  3663 TGCV-------KNLSLMNARPGEQ 3679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831 9/48 (19%)
Cadherin_repeat 549..>625 CDD:206637 11/76 (14%)
Cadherin_repeat 655..752 CDD:206637 20/114 (18%)
Cadherin_repeat 765..853 CDD:206637 16/89 (18%)
Cadherin_repeat 862..964 CDD:206637 19/119 (16%)
Cadherin_repeat 973..1074 CDD:206637 20/114 (18%)
Cadherin_repeat 1083..1166 CDD:206637 21/100 (21%)
Cadherin_repeat <1219..1298 CDD:206637 19/97 (20%)
Cadherin_repeat 1310..1414 CDD:206637 23/117 (20%)
Cadherin_repeat 1423..1514 CDD:206637 15/99 (15%)
Cadherin_repeat 1522..1630 CDD:206637 16/107 (15%)
Cadherin_repeat 1638..1741 CDD:206637 19/103 (18%)
Cadherin_repeat 1762..1861 CDD:206637 15/98 (15%)
Cadherin_repeat 1871..1966 CDD:206637 33/195 (17%)
Cadherin_repeat 1974..2083 CDD:206637 25/141 (18%)
EGF 2350..2380 CDD:278437 9/31 (29%)
LamG 2385..2570 CDD:238058 47/190 (25%)
EGF_2 <2605..2631 CDD:285248 8/25 (32%)
Laminin_G_2 2665..2800 CDD:280389 33/159 (21%)
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
hspg2XP_021325650.1 SEA 84..198 CDD:321958
LDLa 216..251 CDD:238060
LDLa 277..311 CDD:238060
LDLa 317..351 CDD:238060
LDLa 360..395 CDD:238060
Ig_Perlecan_like 413..490 CDD:143220
Laminin_B 598..732 CDD:306547
EGF_Lam 766..814 CDD:238012
EGF_Lam 831..869 CDD:238012
Laminin_EGF 871..923 CDD:278482
Laminin_B 991..1125 CDD:306547
Laminin_EGF 1159..1206 CDD:278482
EGF_Lam 1208..1261 CDD:238012
Laminin_EGF 1272..1315 CDD:278482
Laminin_B 1536..1671 CDD:306547 32/160 (20%)
EGF_Lam 1705..1754 CDD:238012 9/58 (16%)
EGF_Lam 1755..1811 CDD:238012 9/55 (16%)
IG_like 1823..1903 CDD:214653 12/94 (13%)
Ig_Perlecan_like 1911..1996 CDD:143231 22/120 (18%)
I-set 2025..2109 CDD:254352 13/83 (16%)
I-set 2119..2231 CDD:254352 22/118 (19%)
I-set 2241..2309 CDD:333254 14/85 (16%)
Ig_3 2333..2407 CDD:316449 13/87 (15%)
Ig_3 2427..2500 CDD:316449 20/126 (16%)
I-set 2517..2606 CDD:254352 30/171 (18%)
I-set 2610..2693 CDD:333254 17/85 (20%)
I-set 2699..2778 CDD:333254 8/78 (10%)
I-set 2785..2867 CDD:254352 23/103 (22%)
I-set 2871..2954 CDD:254352 13/84 (15%)
LamG 2961..3119 CDD:238058 36/230 (16%)
EGF_CA <3146..3175 CDD:238011 11/50 (22%)
LamG 3226..3377 CDD:238058 46/187 (25%)
EGF 3402..3433 CDD:306513 2/30 (7%)
EGF_CA 3441..3470 CDD:238011 8/32 (25%)
LamG 3497..3671 CDD:238058 40/195 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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