DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and PCDHB14

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_061757.1	Gene:	PCDHB14 / 56122	HGNCID:	8685	Length:	798	Species:	Homo sapiens

Alignment Length:	713	Identity:	185/713 - (25%)
Similarity:	306/713 - (42%)	Gaps:	123/713 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   640 LSIVGGKRA---PQFYMPSYEAEIPE---NQKKD-----SDIISIKAKSFADREIRYTLKAQGQG 693
            |.::|..||   ...|..:.|.||..   |..:|     .::.|.:|:..:|...:|
Human    18 LVLLGLSRAGTESAHYSVAEETEIGSFVANLARDLGLGVEELSSREARVVSDDNKKY-------- 74

  Fly   694 AGTFNIGPTSGIVKLAKELDFEDL---RQPHVYSLIVTATEDSGGFSTSVDLTIRVTDVNDNAPK 755
               .::...:|.:.|.::||.::|   .:|.|....|........|.    ..:.|.|:||::|.
Human    75 ---LHLDLLTGNLLLNEKLDRDELCGSTEPCVLHFQVVLENPLQFFR----FELCVKDINDHSPT 132

  Fly   756 FELPDYQAHNVDEDIPLGTSILRVKAMDSDSGSNAEIEYLVS-DDHFAV---DSNG-----IIVN 811
            | |.......:.|...:|.:.|...|.|.|.|||:...|.:| :.||.:   ||:.     .:|.
Human   133 F-LDKEILIKISEGTTVGATFLMESAQDLDVGSNSLQNYTISPNSHFYIKIPDSSDRKIYPELVL 196

  Fly   812 NKQLDADNNNAYYEFIVTAKDKGEPPKSGVATVRVYTKNKNDEEPKFSQQVYTPNVDENAGPNTL 876
            ::.||.: ..|.....:||.|.|.|||||...|.:...:.||..|:|.|.:|...|.|:....:.
Human   197 DRALDYE-QEAELRLTLTAVDGGSPPKSGTTLVLIKVLDINDNAPEFPQSLYEVQVPEDRPLGSW 260

  Fly   877 VTTVVASDKDGDN---VRFGFVGGGTSSGQ-FVIEDITGVIRLHNKAISLDKD---KYELNVTAM 934
            :.|:.|.|.|..|   :.:.|........: |.|..|:|.:.|.:   .||.:   .|.:|:.|.
Human   261 IATISAKDLDAGNYGKISYTFFHASEDIRKTFEINPISGEVNLRS---PLDFEVIQSYTINIQAT 322

  Fly   935 DDGSCCVNGDQTIHTSTAVVVVFITDVNDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVAT--DED 997
            |.|.  ::|..|:       :|.:.|:|||.|.. ..|:...::.|   |.|..:..:.:  |:|
Human   323 DGGG--LSGKCTL-------LVKVMDINDNPPEV-TISSITKRIPE---NASETLVALFSILDQD 374

  Fly   998 KGVNGQVKYSIVQ------QPNQKGTKFTVDEETGEVSTNKVFDREGDDGKFVSVTVKATDQGDP 1056
            .|.||::..||..      :|..|.. ||:..|       |..|||......:::||  ||.|.|
Human   375 SGDNGRMICSIQDNLPFFLKPTFKNF-FTLVSE-------KALDRESQAEYNITITV--TDLGTP 429

  Fly  1057 SLEGVCSFTVEITDVNDNPPLFDRQKYVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTAPF 1121
            .|:...:.||.::|||||.|.|.:..|...|:::.|...:|..|||:|.|:..|..:.|||   .
Human   430 RLKTEYNITVLLSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSL---L 491

  Fly  1122 NPND-----LEYFEIQAESGWIVLKKPLDGCYPR-DRYRLRVSASDKGTPASAADVDVELDVVDR 1180
            .|.|     .....|.|::|.:...:.||  |.. ..:..||.|:|:|:||.:::..|.:.|:|.
Human   492 PPQDRHLPLASLVSINADNGHLFALRSLD--YEALQEFEFRVGATDRGSPALSSEALVRVLVLDA 554

  Fly  1181 NNKPPIWDKSIYGPIH---------IRENVTVGTVVTSVKASSGIEG-NPTVFYRLMPGSTAQTN 1235
            |:..|.    :..|:.         :......|.:||.|.|..|..| |..:.|:|:..:
Human   555 NDNSPF----VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT----- 610

  Fly  1236 KFHTFYLQQRPDNGDTWA---DIKVNHPLDYESIKEYNLTIRVENNGAQQLASEATVYIMLED 1295
                     .|.....||   :::....|......::.|.:.|::||....::.||::::|.|
Human   611 ---------EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637	21/107 (20%)
		Cadherin_repeat	765..853	CDD:206637	29/96 (30%)
		Cadherin_repeat	862..964	CDD:206637	26/108 (24%)
		Cadherin_repeat	973..1074	CDD:206637	31/108 (29%)
		Cadherin_repeat	1083..1166	CDD:206637	26/88 (30%)
		Cadherin_repeat	<1219..1298	CDD:206637	15/80 (19%)
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
PCDHB14	NP_061757.1	Cadherin_2	32..112	CDD:285466	18/90 (20%)
		Cadherin_repeat	140..238	CDD:206637	30/98 (31%)
		Cadherin_repeat	247..343	CDD:206637	26/107 (24%)
		Cadherin_repeat	355..447	CDD:206637	31/104 (30%)
		Cadherin_repeat	455..557	CDD:206637	32/106 (30%)
		Cadherin_repeat	576..664	CDD:206637	21/101 (21%)
		Cadherin_C_2	685..768	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910