DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and celsr2

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_001074046.1 Gene:celsr2 / 560426 ZFINID:ZDB-GENE-070122-2 Length:2941 Species:Danio rerio


Alignment Length:2110 Identity:507/2110 - (24%)
Similarity:818/2110 - (38%) Gaps:572/2110 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   960 DVNDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSI-VQQPNQKGTKFTVDE 1023
            :||:| |.|.. ..|...|.|..|.|:.|:.:.|.|.|:|..|:::|.: ....::....|.||.
Zfish   236 NVNNN-PQFHP-PMYQVSVPENQPAGTFVVVLKAVDPDEGEAGRLEYVLEALFDSRSNNLFAVDP 298

  Fly  1024 ETGEVSTNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFDRQKYVENVK 1088
            .:|.|||.::.|||..|.....||  |.|.|.|....:.:.||.::|.||:.|.|::|.|.|:::
Zfish   299 ASGVVSTVEILDRETKDTHVFRVT--AVDHGTPRRTAMATLTVTVSDTNDHDPAFEQQDYKESIR 361

  Fly  1089 QDASIGTNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVLKKPLDGCYPR--- 1150
            ::..||..:|.|.|:|.||..||.|:|.|......||:  |||.:.||.|..:    |...|   
Zfish   362 ENLEIGYEVLTVRATDGDAPINGNILYHLLNSNGTNDV--FEIDSRSGVIRTR----GLVDRETV 420

  Fly  1151 DRYRLRVSASDKGT---PASAADVDVELDVVDRNNKPPIWDKSIYGPIHIRENVTVGTVVTSVKA 1212
            |.|.|.|.|:|:|.   |.||. ..|.:.|.|.|:..|.:.:..| .:.:.|::|..|.:..|.|
Zfish   421 DSYMLMVEANDQGRDPGPRSAT-ATVHIVVEDDNDNAPQFSEKRY-IVQVPEDLTPNTEILQVTA 483

  Fly  1213 SSGIEG-NPTVFYRLMPGST-------AQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEY 1269
            :....| |..|.:.:|.|:|       |||.|                  :.:...||||..|||
Zfish   484 TDQDRGNNAVVHFSIMSGNTRGQFYIDAQTGK------------------LDLVSQLDYEMNKEY 530

  Fly  1270 NLTIRVENNGAQQLAS-EATVYIMLEDVNDEIPLFTERE-QETVLEGEPIGTKVTQVNAIDKDGT 1332
            .|.||.::.|...|:: ...|.:.:.|:||..|:|.... |.||||..|:|..|..:.|:|.|..
Zfish   531 TLRIRAQDGGRPPLSNISGLVTVQVLDINDNAPIFVSTPFQATVLENVPVGYSVIHIQAVDADAG 595

  Fly  1333 FPNNQVYYYIVDSPRNEGKEF-FEINLQSGEIFTKTVFDREKKGAYALEVEARD-GAPSARPNSN 1395
             .|:::.|.:.::..|    | |.||..:|.|......|||....|...||||| |||:...:::
Zfish   596 -DNSRLEYRLTETTAN----FPFTINNSTGWIVVAAELDRETVDFYNFGVEARDHGAPAMSSSAS 655

  Fly  1396 GPNSVTKFIRIGIADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGNI 1460
                    |.:.|.|.|||.|.|.:..|...::|:..:..:|:||:|.|.|.:|.:.|:|:|||.
Zfish   656 --------ISMTILDVNDNNPEFTQKAYYMRLNEDAAVGTSVVTVSAVDQDINSVVTYQISSGNT 712

  Fly  1461 GGAFAVKNMTGA--IYVAGALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTY 1523
            ...|::.:.:|.  |.:|..|||:..|:|.|.:.|||..:.:...|.::|.|.|.:.|||:...|
Zfish   713 RNRFSITSQSGGGLITLALPLDYKLERQYVLTVTASDGTRFDTAKVYVNVTDANTHRPVFQSSHY 777

  Fly  1524 RTQITEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKP 1588
            ...|.|  ||.:...|:.::|||.|......|.|.:     |...|   :|:|:..:|.:.....
Zfish   778 TVNINE--DRPVGTTVVMISATDEDTGENARITYIM-----DDSIP---QFNIDADSGAVTTQME 832

  Fly  1589 LD-RDQPNGRPQWRFTVFAQDEG--GEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAG 1650
            || .||.:    :...:.|:|.|  .:....|.::.||  |:|||:|:|.:..|.|:|.|:....
Zfish   833 LDYEDQVS----YTLAITARDNGIPQKSDTTYLEILVN--DVNDNSPVFQRDRYLGSVMEDIPVF 891

  Fly  1651 MVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYS 1715
            ..|:.::|.|.|   .|.|.|:.|:.:..    |.|...|.||..:|:::| :..||||.|..|:
Zfish   892 TSVLQVSATDRD---SGLNGRVFYTFQGG----EDGDGDFIIESTSGIVRT-LRRLDRENTAIYN 948

  Fly  1716 IQVVAMDGG--GLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDE 1778
            :|..|:|.|  .||......:.:.|:||.||.|.|||:                           
Zfish   949 LQAFAVDKGVPALKTAVDMQVTILDVNDNPPVFEKDEF--------------------------- 986

  Fly  1779 TNKFQYKVIDNSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDK 1843
                                                                             
Zfish   987 ----------------------------------------------------------------- 986

  Fly  1844 YHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSS 1908
                                       ::.|.|::.:|..:....|:|||:|..:::.|.|...:
Zfish   987 ---------------------------DIFVEENSPIGLVVAHISASDPDEGSNAQIMYQIVEGN 1024

  Fly  1909 DRQRQFAIN-QNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLK 1972
            ..: .|.:: .:|.:|....||.|....:   ::.:...|.|..:.||:.:.:.|.|||.| .||
Zfish  1025 IPE-VFQLDIFSGELTALTDLDYETRAEY---VIVVQATSAPLVSRATVHIKLIDKNDNVP-VLK 1084

  Fly  1973 DYRPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMA 2037
            :::.:...:|          ||     |:|                                   
Zfish  1085 NFQIIFNNYV----------TD-----KTN----------------------------------- 1099

  Fly  2038 VISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQSP 2102
                  ||                                                        |
Zfish  1100 ------SF--------------------------------------------------------P 1102

  Fly  2103 DTPIGRVYVYDLDDWDLPDKKFYWEAMEHPRFKLDEDSGMVTMRAGTREGRY------------H 2155
            ...|||:   ...|.|:.|:..|       .|:...:..:|.:...|.|.|.            .
Zfish  1103 SGVIGRI---PAQDPDVSDQLHY-------SFEAGNELKLVILNQSTGEIRLSRALDNNRPLEAS 1157

  Fly  2156 LRFKVYDRKHTQTDIPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSRSKMDR 2220
            ::..|.|..|:   :.|...:.|..|..|.:.||.::||:..|.|.|:.:           .:.:
Zfish  1158 MKISVSDGVHS---VSAQCLLQVTVITDEMLSNSITLRLANASQERFLSL-----------LLAQ 1208

  Fly  2221 FRDKLADLLNTERENVDIFSVQLKRKHPPLTDVRFSAHGSPYYKPVRLNG-------------IV 2272
            |.:.:|.:|:..||:|.:|::|        .|...||........|.|.|             :.
Zfish  1209 FLEGVASVLSASREDVVVFNIQ--------DDTDVSAGILNVSLSVALPGQGSRGRGVSQGSEVE 1265

  Fly  2273 LMHREEIEKDVGINITMVG---------IDECLYENQMCEG--SCTNSLEISPL-PYMVNANKTA 2325
            ....||:::.:.:|.:::.         .|:.:...:.||.  .|.:.|:...| |::  |:.|.
Zfish  1266 FFGSEELQERLYLNRSLLAQISSQEVLPFDDNICLREPCENYMKCVSVLKFDSLAPFV--ASDTI 1328

  Fly  2326 L-------VGVR---------------VDTIADCTCGARNFTKPES------------------- 2349
            |       .|:|               :|......|||....:...                   
Zfish  1329 LFRPIHPIAGLRCRCPLGFTGDYCETEIDLCYSRPCGAHGVCRSHEGGYTCHCMQDYTGERCEIS 1393

  Fly  2350 -----CRTTPCHNGGRCVDTRFGP-HCSCPV-GYTGPRCQQTTRSFRGNGWAWYPPLEMCDESHL 2407
                 |....|.|||.|::...|. .|.||. |:..|.|..::|:|....:..:..|.......|
Zfish  1394 SRSGRCAEGVCKNGGTCLNLLVGGFRCECPSGGFEKPFCLLSSRNFPPQTFITFKGLRQRFHFTL 1458

  Fly  2408 SLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKT--- 2469
            ||.|.||:|:||::|||......       ||||:|:..  .::.:.|.:|      .||.|   
Zfish  1459 SLSFATREPNGLLLYNGRFNEKH-------DFIAMEIVN--QQIQLTFSAG------GTKTTVLP 1508

  Fly  2470 -----LDDGEWHRIDLFW----------------DTESIRMVVDFCKSAEIAEMEDGTPPEFDDM 2513
                 :.||.||...:.:                |.:.:.:.||.|.|:.......    ...:.
Zfish  1509 FIEGGVSDGHWHTAHVHYYNKPVLNRAGLPQGPSDQKVVVVTVDDCDSSVALRFGH----VVGNY 1569

  Fly  2514 SCQARGQIPPFNEYLNVNAPLQVGG---LYREQFDQSLYFWHYMPTA-KGFDGCIRNLVHNSKLY 2574
            ||.|:|......:.|::..||.:||   ...|:|          |.. :.|.||:::|..:.:..
Zfish  1570 SCSAQGSQLGSKKSLDLTGPLLLGGGVPKLPEEF----------PVQNRQFIGCMKDLRIDERHV 1624

  Fly  2575 DLAHPGLSRNSVAGCPQTEEVCAQTETTARCWEHGNCVGSLSEARCHCRPGWTGPAC-NIPTIPT 2638
            |:|....:..::.||......|....    |...|:||......||.|..|:.|..| .:.:.|.
Zfish  1625 DMAGFIANNGTLPGCSAKRNFCNNNP----CLNGGSCVSLWGSFRCDCALGFGGRNCEKVMSNPL 1685

  Fly  2639 TFKAQSYVKYALSFEPDRFST-----QVQLRFRTREEYGELFRVS--DQHNREYGILEIKDGHLH 2696
            ..:.:..:.:|     |..|.     .::..||||:....:..:|  .|||   ..:::::|   
Zfish  1686 RLQGKGLLWWA-----DLASVMTPPWHMEFMFRTRQPTATVMHMSSGQQHN---FTIQLREG--- 1739

  Fly  2697 FRYNLNSLRTEEKDL--WLNAIVVNDGQWHVVKVNRYGSA-----ATLELDGGEGRRYNETFEFV 2754
              :.:.|::..|..:  .::.:.|:|||||.|.:...|.|     |||.||.|   .|..:.:  
Zfish  1740 --FVVTSVQRGEDSVVSRVDDVTVSDGQWHHVSLELKGPATGGVTATLSLDYG---LYTSSMD-- 1797

  Fly  2755 GHQWLLVDKQEGV-----YAGGKAEYTGVRTFEVYADYQKSCLDDIRLEG-KHLPLPPAMNGTQW 2813
                 |..|.:||     ..||.::...    .|...: :.|:..:|:.| ...|..|:|     
Zfish  1798 -----LDSKLKGVRLKTLSVGGVSDGRN----RVIGGF-RGCIQGLRIGGDSSTPAFPSM----- 1847

  Fly  2814 GQATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPC 2878
            .||.:. |:|.||.....|.:..||...:|.|.|:.:.|.|..|..    ...|.|  .|...||
Zfish  1848 PQARVL-NVESGCSLPNTCGSNPCPAHSDCKDDWDAHSCRCHTGYY----GNSCTD--ACALNPC 1905

  Fly  2879 MNGATCINLEPRLR-YRCICPDGFWGENCE 2907
            .:.:.|........ |.|.||..::|:.||
Zfish  1906 EHQSACSRRSSSAHGYTCSCPSNYFGQYCE 1935

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637 2/3 (67%)
Cadherin_repeat 973..1074 CDD:206637 33/101 (33%)
Cadherin_repeat 1083..1166 CDD:206637 32/88 (36%)
Cadherin_repeat <1219..1298 CDD:206637 23/86 (27%)
Cadherin_repeat 1310..1414 CDD:206637 35/105 (33%)
Cadherin_repeat 1423..1514 CDD:206637 31/92 (34%)
Cadherin_repeat 1522..1630 CDD:206637 29/110 (26%)
Cadherin_repeat 1638..1741 CDD:206637 32/104 (31%)
Cadherin_repeat 1762..1861 CDD:206637 0/98 (0%)
Cadherin_repeat 1871..1966 CDD:206637 22/95 (23%)
Cadherin_repeat 1974..2083 CDD:206637 7/108 (6%)
EGF 2350..2380 CDD:278437 11/31 (35%)
LamG 2385..2570 CDD:238058 50/212 (24%)
EGF_2 <2605..2631 CDD:285248 9/25 (36%)
Laminin_G_2 2665..2800 CDD:280389 37/149 (25%)
EGF_CA 2869..2907 CDD:238011 10/38 (26%)
Cadherin_C 2952..3088 CDD:279398
celsr2NP_001074046.1 Cadherin_repeat 248..347 CDD:206637 33/100 (33%)
Cadherin_repeat 356..455 CDD:206637 39/105 (37%)
Cadherin_repeat 464..561 CDD:206637 31/115 (27%)
Cadherin_repeat 569..666 CDD:206637 36/109 (33%)
Cadherin_repeat 675..768 CDD:206637 31/92 (34%)
Cadherin_repeat 776..871 CDD:206637 29/110 (26%)
Cadherin_repeat 880..977 CDD:206637 33/104 (32%)
Cadherin_repeat 985..1079 CDD:206637 23/216 (11%)
Cadherin_repeat 1099..1180 CDD:206637 21/190 (11%)
EGF_CA 1356..1391 CDD:238011 4/34 (12%)
EGF_CA 1399..1432 CDD:238011 12/32 (38%)
LamG 1436..>1529 CDD:238058 29/107 (27%)
EGF_CA 1644..1678 CDD:238011 10/37 (27%)
Laminin_G_2 1712..1837 CDD:280389 36/147 (24%)
EGF_CA 1863..1897 CDD:238011 9/37 (24%)
TNFRSF 1924..1993 CDD:304602 5/12 (42%)
EGF_Lam 1992..2037 CDD:214543
HormR 2041..2102 CDD:214468
GAIN 2120..2358 CDD:293098
GPS 2386..2439 CDD:197639
7tm_4 2445..2677 CDD:304433
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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