DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and dsc2l

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_001274012.1 Gene:dsc2l / 560091 ZFINID:ZDB-GENE-031116-55 Length:934 Species:Danio rerio


Alignment Length:994 Identity:242/994 - (24%)
Similarity:372/994 - (37%) Gaps:282/994 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   531 ILVKDVNDEPP-YFINRPLPMQAVVQLNAPPNTPV-FTLQARDPD----TDHNIHYFIVRDRTGG 589
            :||:..|..|. |||.:       |.||.....|| ||  :.|||    ||.:|           
Zfish    71 VLVQVPNTVPAGYFITQ-------VTLNGCTAIPVSFT--SSDPDFTVNTDGSI----------- 115

  Fly   590 RFEVDERSGVVRTRGTDLFQLD-------MEYVLYVKAEDQNGKVDDRRFQSTPEERLSIVGGKR 647
               |..||.|:.|:...:...|       :|.:|..|.||              .::...|..||
Zfish   116 ---VTLRSLVISTKRFSVLVQDNSGLDWRVEIILSCKNED--------------SQKSGSVAQKR 163

  Fly   648 APQFYMPSYEAEIPENQK----KDSDIISIKAKSFADREIRYTLK--AQGQGA-----GTFNIGP 701
            |.:.:.| ....:.||..    ||.::|:      :|..:.||:.  ..|||.     |.|.:..
Zfish   164 AKRRWRP-LPFSVVENASPPFPKDVEMIA------SDSSVNYTVHYVISGQGVTEEPIGLFQLDQ 221

  Fly   702 TSGIVKLAKELDFEDLRQPHVYSLIVTATEDSGGFSTSVD----LTIRVTDVNDNAPKFELPDYQ 762
            .:|:|::...:|.|  :.|. ::.|..|.:.:   :..||    :|:.|.|||||||:|  ...:
Zfish   222 KTGMVRVTGPVDRE--KNPE-FNFIARAFDQN---NREVDQFLPITVMVEDVNDNAPEF--TGNR 278

  Fly   763 AHNVDEDIPLGTSILRVKAMDSDSGS--NAEIEYLV--SDDHFAVDSNGIIVNNKQLDADNNNAY 823
            ...|:|....||.:.:|.|.|.|...  ::.|:|::  :.|.|::|.:..|:..|....|.....
Zfish   279 FFTVEERCRAGTRVGQVNATDRDQPKTPHSLIKYILLNATDMFSIDQSTGIITAKSNTLDREAQD 343

  Fly   824 YEFI-VTAKDKGEPPKS----GVATVRVYTKNKNDEEPKFSQQVYTPNVDENAGPNTLVTTVVAS 883
            ..|: |..:|.|..|..    |.|.:.:  .:.||..|.|.:::|...:.||.. |.|||.:...
Zfish   344 KVFVGVEIRDMGGAPNGLFNRGTAVISL--TDVNDNPPTFKEKLYKGTIKENLA-NVLVTRIPVE 405

  Fly   884 DKDGDNV----RFGFVGGGTSSGQFVI-------EDITGVIRLHNKAISLDKDK---YELNVTAM 934
            |||..|.    ....|..|..:|.|.:       |.:..|::      .||.:|   ..|.|||.
Zfish   406 DKDLVNTPNWKAVYEVTKGNENGNFRMETDPKTNEGLLYVVK------GLDFEKTPVMNLEVTAR 464

  Fly   935 DDGSCCVNGDQTIHTSTAVVVVFITDVNDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATD-EDK 998
            ::.. .|..|  ....:..:.:.:.|| |..|.|.. :..|.||:|..|||:.:....|.| |.|
Zfish   465 NEAP-LVGTD--AKWQSVPLQLNVEDV-DEGPEFNP-NIMYLKVKENLPNGTVIGTYKALDPETK 524

  Fly   999 GVNGQVKYSIVQQPNQKGTKFTVDEETGEVSTNKVFDREGD--DGKFVSVTVKATDQGDPSLEGV 1061
            ..|| :||..:..|   |...||.|.|||:......|||..  .....::|:||.|:...:..||
Zfish   525 NSNG-IKYYKLTDP---GNWITVVESTGELKVANTIDRESSLVHNDTYNITIKAVDESKKTGNGV 585

  Fly  1062 CSFTVEITDVNDNPPLFDRQKYVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTAPFNPNDL 1126
              ..::|.|||||.|:..|...  |:.......:::| |.|.|:|..     .||  .||     
Zfish   586 --VILQIEDVNDNIPVIRRPDL--NMCNRGDAVSSVL-VEAVDQDKP-----PYS--TPF----- 633

  Fly  1127 EYFEIQAESGWIVLKKPLDGCYPRDRYRLRVSASDKGTPASAADVDVELDVVDRNNKP------- 1184
             .||:.||.              ..:::|:          ...|..|.|..||    |       
Zfish   634 -IFELGAEQ--------------EGKWKLK----------DITDSSVVLQQVD----PMPNGMYT 669

  Fly  1185 -PIWDKSIYGP-----IHI------RENVTVGTVVTSVKASSGIEGNPTVFYRLMPG-------- 1229
             ||..|.:.|.     :::      ||::.||  :...:::|...||..:...::.|        
Zfish   670 VPITVKDLQGTGKEQIVNVRVCSCQREDMGVG--ICGARSASVSLGNYGILALVLSGLLLLLLCL 732

  Fly  1230 -----STAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEYNLTIRVENNGAQQLASEATV 1289
                 .|.:.:|     ||...|.|.....:|.|.....|.:|:..|.:                
Zfish   733 FLIFFCTTKRDK-----LQITDDTGTGGILLKSNTEAPGEEVKDGTLLL---------------- 776

  Fly  1290 YIMLEDVNDEIPLFTEREQETVLEGEPIGTKVTQVNAIDKDGTFPNNQVYYYIVDSPRNEGKEFF 1354
             |...||.|      ...|..|.|.:.:.|                         :|...|::||
Zfish   777 -IPTADVVD------GSFQSAVTESKNVNT-------------------------APGRYGQQFF 809

  Fly  1355 EINLQSGEIFTKTV--FDREK---KGAYALEVEARDGAPSARPNSNGPNSVTKFIRIGIADK-ND 1413
                |||.::..|.  |..::   .|.|..::             .|..::.||...|..|. ..
Zfish   810 ----QSGGVYNTTTQEFGTDQYYTSGRYDNKI-------------YGNGTLQKFSNTGTLDTWRT 857

  Fly  1414 NPPYFDKSLYEAEVDENED 1432
            |..|.|:.|  |...|.||
Zfish   858 NGCYLDRKL--AYFGEQED 874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831 3/9 (33%)
Cadherin_repeat 549..>625 CDD:206637 24/87 (28%)
Cadherin_repeat 655..752 CDD:206637 27/111 (24%)
Cadherin_repeat 765..853 CDD:206637 23/96 (24%)
Cadherin_repeat 862..964 CDD:206637 28/115 (24%)
Cadherin_repeat 973..1074 CDD:206637 36/103 (35%)
Cadherin_repeat 1083..1166 CDD:206637 15/82 (18%)
Cadherin_repeat <1219..1298 CDD:206637 16/91 (18%)
Cadherin_repeat 1310..1414 CDD:206637 19/109 (17%)
Cadherin_repeat 1423..1514 CDD:206637 4/10 (40%)
Cadherin_repeat 1522..1630 CDD:206637
Cadherin_repeat 1638..1741 CDD:206637
Cadherin_repeat 1762..1861 CDD:206637
Cadherin_repeat 1871..1966 CDD:206637
Cadherin_repeat 1974..2083 CDD:206637
EGF 2350..2380 CDD:278437
LamG 2385..2570 CDD:238058
EGF_2 <2605..2631 CDD:285248
Laminin_G_2 2665..2800 CDD:280389
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
dsc2lNP_001274012.1 Cadherin_pro 66..140 CDD:214999 26/91 (29%)
Cadherin_repeat 170..270 CDD:206637 28/112 (25%)
Cadherin_repeat 279..377 CDD:206637 24/99 (24%)
Cadherin_repeat 386..490 CDD:206637 28/114 (25%)
Cadherin_repeat 498..596 CDD:206637 36/103 (35%)
E_set 619..690 CDD:298831 23/111 (21%)
Cadherin_C <861..925 CDD:279398 7/16 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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