DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and egfl6

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_017213153.1	Gene:	egfl6 / 436730	ZFINID:	ZDB-GENE-040718-157	Length:	539	Species:	Danio rerio

Alignment Length:	363	Identity:	67/363 - (18%)
Similarity:	99/363 - (27%)	Gaps:	188/363 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly  2580 GLSRNSVAGCPQTEEVCAQTETTARC---WEHGNCVGSLSEARCHCRPGWTGPACN-------IP 2634
            |..:|:...|            .|:|   .:||.|||   ..:|.|.||:||..|:       :.
Zfish    49 GWKKNTKGQC------------EAQCDLGCKHGECVG---PNKCKCFPGYTGKTCSQDLNECGLK 98

  Fly  2635 TIPTTFKAQ----SYVKYALSFEPDRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGH- 2694
            ..|...:..    ||:.|.|:                                  |.:.:.||.
Zfish    99 PRPCEHRCMNTFGSYMCYCLN----------------------------------GYMLMPDGSC 129

  Fly  2695 --------LHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEGRRYNETF 2751
                    .|.:|....:::|     :..:..:.|               |:| |.:|
Zfish   130 ANSRTCSLAHCQYGCEEVQSE-----VRCLCPSPG---------------LQL-GSDG------- 166

  Fly  2752 EFVGHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKSCLD-DIRLEGKHLPLPPAMNGTQWGQ 2815
                                                 |:|.| |....||:
Zfish   167 -------------------------------------KTCEDIDECATGKN-------------- 180

  Fly  2816 ATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRIMSPDSK------GCMDRNECL 2874
                     .||.|:.|:|.           :..|.|.|..|.    |.|      .|:|.|||.
Zfish   181 ---------QCPFNRQCTNT-----------FGSYYCKCQPGY----DLKYINGKYDCVDVNECT 221

  Fly  2875 D--MPCMNGATCINLEPRLRYRCICPDGFWGE--NCEL 2908
            .  ..|.:.|.|||...  .|:|.|..||.|.  :|.:
Zfish   222 SNTHKCSHHAECINTLG--SYKCKCKQGFRGSGFDCSV 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248	12/28 (43%)
		Laminin_G_2	2665..2800	CDD:280389	15/144 (10%)
		EGF_CA	2869..2907	CDD:238011	15/41 (37%)
		Cadherin_C	2952..3088	CDD:279398
egfl6	XP_017213153.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910