DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and MFGE8

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_005919.2	Gene:	MFGE8 / 4240	HGNCID:	7036	Length:	387	Species:	Homo sapiens

Alignment Length:	298	Identity:	61/298 - (20%)
Similarity:	109/298 - (36%)	Gaps:	83/298 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  2314 PLPYMVNANKTALVGVRVDTIADCTCGARNFTKPESCRTTPCHNGGRCVDTR-------FGPH-C 2370
            |.|.::.|...||:           |........:.|...||||||.|.:..       |..: |
Human     2 PRPRLLAALCGALL-----------CAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTC 55

  Fly  2371 SCPVGYTGPRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYNGPIVPPERDETL 2435
            :|..||.|..|:                              |:..:.|.:.||.|...:...:.
Human    56 TCLKGYAGNHCE------------------------------TKCVEPLGLENGNIANSQIAASS 90

  Fly  2436 ISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDL---FWDTESIRMVV------ 2491
            :. ...|.|:...|.|.....:|.  :...|..:.||..|.:::|   .|.|..:....
Human    91 VR-VTFLGLQHWVPELARLNRAGM--VNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASH 152

  Fly  2492 DFCKSAEIAEMEDGTPPEFD---DMSCQARGQIPPFNE---YLNV-NAPLQVGGLYREQFDQSLY 2549
            ::.|:.::|...:|  .|||   |::.:.:..:..:|:   ::|: ..|::.      |:.: ||
Human   153 EYLKAFKVAYSLNG--HEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEA------QYVR-LY 208

  Fly  2550 FWHYMPTAKGFDGCIRNLVHNSKLYDLAHP-GLSRNSV 2586
                 ||:......:|..:...:|...|:| ||..||:
Human   209 -----PTSCHTACTLRFELLGCELNGCANPLGLKNNSI 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	14/37 (38%)
		LamG	2385..2570	CDD:238058	33/200 (17%)
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
MFGE8	NP_005919.2	EGF_CA	28..67	CDD:238011	13/38 (34%)
		Cell attachment site	46..48		0/1 (0%)
		FA58C	72..224	CDD:238014	32/168 (19%)
		FA58C	232..386	CDD:238014	5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910