DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and Cad87A

DIOPT Version :10

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster


Alignment Length:2038 Identity:474/2038 - (23%)
Similarity:790/2038 - (38%) Gaps:414/2038 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   455 TEGKSVFQLE---KETDKETFKIRDDNPWVTVETNGAVRVKKKWDYEELGPEKTIDFWVIITNMG 516
            |.|..||:||   .|....|:.....:.:.....:|.:.:.|..|.||   :.|:.|.|.|.:..
  Fly    41 TVGTVVFRLEAYDPEGSPVTYGAIGADHFSVDPVSGNITLIKPLDREE---KDTLKFLVSIRDRV 102

  Fly   517 HNAGIKYTDN---QRVIILVKDVNDEPPYFINRPLPMQAVVQLNAPPNTPVF---TLQARD---- 571
            ...|....||   ..:..::.|:||.||.|.|  .|.:|.|..:|...|.:|   |::.||    
  Fly   103 DPEGESERDNVVEVPITFIILDLNDNPPEFQN--TPYEADVNEDAAVGTTIFDKITVKDRDIVGE 165

  Fly   572 ------------PDTDHNIHYFIV-RDRTGGRFEVDERSGVVRTRGTDLFQLDMEYVLYVKAEDQ 623
                        |:........|: ||.|     :.|.:.|:    .|....:...|.:.:.|..
  Fly   166 SLDLKCLPQQQSPEACRKFRLHIIKRDAT-----ILEAAVVL----NDTLNYNQRMVYHFQIEAT 221

  Fly   624 NGKVDDRRFQSTPEERLSIVGGKRAPQFYMPSYEAEIPENQKKDSDIISIKAK---SFADREIRY 685
            :|   ..:.|:|.|.|:..|..|  |..:..|....|.|:...::.::::.|:   :...|:|.|
  Fly   222 DG---PHKTQTTFEARVKDVQDK--PPVFQGSLSTVIDEDSPINTLVLTVHARDGDTGEPRKIVY 281

  Fly   686 TLKAQGQGAGTFNIGPTSGIVKLAKELDFEDLR-QPHVYSLIVTATEDSGGF-------STSVDL 742
            .|:....  ..|.:...:|.::.||.||.|.|. ...:.||::.|.|...|.       |.:...
  Fly   282 DLRTNPN--DYFLLDAQTGELRTAKPLDREALEDSTGIISLVIRARELVNGVPSDDPLTSATAKA 344

  Fly   743 TIRVTDVNDNAPKFELPDYQAHNVDEDIPLGTSI-LRVKAMDSDSGSNAEIEYLVSDDHFAVDSN 806
            |:.:.||||:.|.|...:|....::..:| ||.: |.:...|:|.|.|::....:.|.....|..
  Fly   345 TVTIRDVNDSPPVFNHKEYSVSLLENTLP-GTPLALDMSVSDADVGINSKFALRLDDVSGVFDVE 408

  Fly   807 ----------GIIVNNKQLDADN-NNAYYEFIVTAKDKGEPPK-SGVATVRVYTKNKNDEEPKFS 859
                      .|.|.|..||.:| |...:..:|.|::....|: |..||:.|...:.||.:|.|.
  Fly   409 PKLVTGYSQVNIRVANGTLDYENPNQRKFIVLVVAEETDTNPRLSSTATITVSVLDANDNKPVFE 473

  Fly   860 QQVYTPNVDENAGPNTLVTTVVASDKD----GDN-VRFGFVGGGTSSGQFVIEDITGVIRL---H 916
            |:.|:.:|.|.|.|...:.|:.|.|.|    ||: :|:..  .||.:..|.:.:.||||.|   |
  Fly   474 QESYSASVSEAALPGQYIATITARDVDSGSYGDSGIRYSL--SGTGAELFHVNEQTGVISLANCH 536

  Fly   917 NKAISLDKDKYELNV---TAMDDGSCCVN------GDQTIHTSTAVVVVFITDVNDNKPVFKDCS 972
            :...|..:::.:||.   ...|||...:.      ..:.|.|...|....||..    |..:..|
  Fly   537 DNGESNRRERRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQA----PEEQASS 597

  Fly   973 TYYP-KVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKGTKFTVDEETGEVSTNKVFDR 1036
            ...| .|...||:|.|   ....::||                              :.....|.
  Fly   598 VPLPAPVPHAAPSGVP---AATANDDK------------------------------APQTCLDY 629

  Fly  1037 EGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFDRQKYVENVKQDASIGTNILRVS 1101
            |.:...|:|  .||||........|.|..:.:||.||:||:.:...|..:|.:.|.:..:.|.|.
  Fly   630 ESETTYFLS--YKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYRASVDEGAVVFDSPLIVK 692

  Fly  1102 ASDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVLK--KPLDGC-YPRDRYRLRVSASDKG 1163
            |  .|||....|.|.:........:  |:|..|:|.|:::  ..||.. ...|:....|.|:|  
  Fly   693 A--RDADTMSRISYRIRGSEQVESI--FDIDRETGQIIIRPNATLDVTNLNSDQLIFAVEAND-- 751

  Fly  1164 TPASAADVDVELDVVDRNNKPPIWDKSIYGPIHIRENVTVGTVVTSVKASSGIEG-NPTVFYRLM 1227
             ....|...|.:.|.|.||..|.:::..|..: :.||..:||.|..|.|:....| |..:.||:.
  Fly   752 -GLFTAHCGVNITVRDVNNHVPNFEQQSYSAV-VEENSEIGTSVERVHATDLDTGKNAELRYRIQ 814

  Fly  1228 PGSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEYNLTIRVENNGAQQLASEATVYIM 1292
            .||      |..|.:.      :|..::.|:..||::....|.|.|:..:.|...|...||:.|.
  Fly   815 QGS------FDDFGIV------ETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTIN 867

  Fly  1293 LEDVNDEIPLFTEREQETVLEGE-PIGTKV---------------------TQVNAIDKDGTFPN 1335
            :::.||:.|.|....|...:..: |.|..|                     ..:.||||:|    
  Fly   868 VQNSNDKDPYFVPATQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAGTDDITAIDKEG---- 928

  Fly  1336 NQVYYYIVDSPRNEGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPSARPNSNGPNSV 1400
            .::.:|      ::.||:|:|: ::|::......||.......:.|...|   |..||......:
  Fly   929 KELPHY------DQFKEYFKIS-RNGKVSVNKQLDRNLFAVMRINVLVTD---STAPNVQQGRGL 983

  Fly  1401 TKFIRIGIADKNDNPPYF------DKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGN 1459
               :.|.|.|.|.|||.|      ::...:.::.|.:.: .||||....:.::||...:.|:..:
  Fly   984 ---LIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPV-GTVLTTLQANDEDSSIGEFNISDND 1044

  Fly  1460 IGGAFAVKNMTGAIYVAGALDYETRRRYELRLAASDNLKENYTT---VIIHVKDVNDNPPVFERP 1521
            .   ||:...:|.||....||||..:..:.::..||......|.   |::.:.::|||.|.|.:.
  Fly  1045 Y---FAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATADVVVDIINLNDNDPKFSQS 1106

  Fly  1522 TYRTQITEEDDRNLPKRVL--QVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIF 1584
            .|...:||    |.|:..:  :|.|.|||......|.|.|.|:.       |..|.|:..||.:.
  Fly  1107 DYYFNVTE----NSPRGTVAGKVEAHDGDVGVFGEITYTLIGEN-------NKYFSIDAYTGNVM 1160

  Fly  1585 VLKP--LDRDQPNGRPQWRFTVFAQDEGGEGL--VGYADVQVNLKDINDNAPIFPQGVYFGNVTE 1645
            |...  |||:|..   :...:|.|||:....:  ...|.:.:|:.|:|||||:|.:.||...|.|
  Fly  1161 VANSSILDREQIK---ELTLSVVAQDKAPAAVQKSATATIHINILDVNDNAPVFTRDVYNSTVAE 1222

  Fly  1646 NGT--AGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDR 1708
            |..  ....::.:.|:|.|   ||     :|...:.:|.......:|:::..:|::..|.....:
  Fly  1223 NAAYQPPAALLQVQAIDQD---EG-----LYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSGK 1279

  Fly  1709 ERTPDYSIQVVAMD---GGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTAL-PEMPIL 1769
            ...  |.:.:.|.|   .|.::.|..|.|.|..:|...|:|..........|..|..: |:..:|
  Fly  1280 HGA--YELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNATIEIPGDIVQPDYLLL 1342

  Fly  1770 TVTVHDED--ETNKFQYKVIDNSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQV 1832
            ||...|.|  |..|..|.:..|:          ||...||..||       |:: :...|.:.|:
  Fly  1343 TVRAMDNDTEENGKVSYHLQVNN----------RNEQQTGEFKI-------DEV-TGELRAKTQL 1389

  Fly  1833 NDK----------GEDNDNDKYHVAYSWVVVKLRDINDNKPHFERAN--VEVSVFEDTKVGTELE 1885
            |.|          ..|..|..:. :...:.|.:.|.|:|:|.|..|:  .:||:.|::....::.
  Fly  1390 NRKNRANYDIILVARDAGNPPFE-SLRLLSVSIVDANENRPEFPDASNPYKVSINENSGRDVKIG 1453

  Fly  1886 KFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQ-NGSVTIQRSLDREVVPRHQVKILA------- 1942
            ..:|....:..:....|.:..:.|  ..|.::: .|.:...:|||||....:.:.|||       
  Fly  1454 HIQAASRSKHNRDIFYYMLLGNED--GAFYVDKLTGDIYTNKSLDREETDVYTLYILASIKADLH 1516

  Fly  1943 IDDGSPPKTATATL---------TVIVQDINDNAPKFLKD-YRPVLPEHVPPRKVVEILATDDDD 1997
            |.:......:..||         .:.|.|:|||.|.|.|. |...:..:......:.::...|.|
  Fly  1517 ISEEERASFSIKTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGVNANAKMGAAITLVNATDAD 1581

  Fly  1998 RSKSNGPPF--------QFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYM 2054
            :.|:....|        :|....|...|:.:.|.:.||.:         ||:........|..:.
  Fly  1582 QGKNAKIEFMIVASNLYKFGATKSTGSIVPSPFAISQDGR---------ISANTIMAEYNQDRFE 1637

  Fly  2055 IPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYVYDLDDWDL 2119
            :.||.::...|..:.::.:.:.:.|                       .|.:.||.:      ..
  Fly  1638 LEIVARELEQPQSSASTKVNIWVFD-----------------------GTQLVRVIL------SR 1673

  Fly  2120 PDKKFYWEAMEHPRFKLDEDSGMVTMRAGTR------EGRYHL----RFKV------YDRKHTQT 2168
            |.::.|.|          ::..:..:|..|:      |.|:||    |.::      :.....||
  Fly  1674 PPEEVYQE----------QEEIIAELRNATQHRIIVDEIRFHLDSIGRIRMDWCDLYFHAVDPQT 1728

  Fly  2169 DIPANVTVTVREIPHE-----------AVVNSGSVRLSGISDE--------------------DF 2202
            ...|.|...:::|...           |:.|.....::.:.||                    .|
  Fly  1729 QQIAPVDEILKDIDRNYDYLKDYYAGFAIENVVPAYIAIVQDEFDLAVAGLVALVIVLFVGVISF 1793

  Fly  2203 I------RVWNYRTQSMSRSKMDRFRDKLADLLNTERENVDIFSVQLK-RKHPPLTDVRFSA--H 2258
            |      :.||......:|.|....:.::.:.||| .||......:|| .:...||...||.  |
  Fly  1794 IVLCCCLKHWNLSVPVETRRKEALIKKQIIEDLNT-TENPLWIEQKLKLYEEQELTMQVFSEPDH 1857

  Fly  2259 GSPYYKPVRLNGIVLMHREEIEK 2281
            .|....|..|:     ||..:|:
  Fly  1858 ISNSEAPGHLD-----HRSSLEQ 1875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
CA_like 449..541 CDD:481204 23/91 (25%)
Cadherin_repeat 549..>625 CDD:206637 19/95 (20%)
Cadherin_repeat 655..752 CDD:206637 26/107 (24%)
Cadherin_repeat 765..853 CDD:206637 24/100 (24%)
Cadherin_repeat 862..964 CDD:206637 32/118 (27%)
Cadherin_repeat 973..1074 CDD:206637 21/101 (21%)
Cadherin_repeat 1083..1166 CDD:206637 22/85 (26%)
Cadherin_repeat <1219..1298 CDD:206637 19/78 (24%)
Cadherin_repeat 1310..1414 CDD:206637 25/125 (20%)
Cadherin_repeat 1423..1514 CDD:206637 22/93 (24%)
Cadherin_repeat 1522..1630 CDD:206637 32/113 (28%)
Cadherin_repeat 1638..1741 CDD:206637 23/107 (21%)
CA 1770..1863 CDD:214520 25/104 (24%)
Cadherin_repeat 1871..1966 CDD:206637 22/111 (20%)
Cadherin_repeat 1974..2083 CDD:206637 18/116 (16%)
EGF 2350..2380 CDD:394967
LamG 2385..2570 CDD:238058
EGF_2 2605..2631 CDD:400365
LamG 2637..2797 CDD:238058
EGF_CA 2869..2907 CDD:238011
CADH_Y-type_LIR 3029..3088 CDD:460041
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637 22/89 (25%)
Cadherin_repeat 136..240 CDD:206637 25/115 (22%)
Cadherin_repeat 248..353 CDD:206637 25/106 (24%)
Cadherin_repeat 362..468 CDD:206637 26/106 (25%)
Cadherin_repeat 476..>533 CDD:206637 19/58 (33%)
CA_like <627..667 CDD:481204 14/41 (34%)
CA 692..772 CDD:214520 23/86 (27%)
Cadherin_repeat 778..873 CDD:206637 28/107 (26%)
Cadherin_repeat 882..994 CDD:206637 26/128 (20%)
Cadherin_repeat 1015..1099 CDD:206637 22/87 (25%)
Cadherin_repeat 1108..1207 CDD:206637 32/112 (29%)
Cadherin_repeat 1215..1314 CDD:206637 24/108 (22%)
Cadherin_repeat 1327..1427 CDD:206637 28/118 (24%)
Cadherin_repeat 1437..1549 CDD:206637 22/113 (19%)
Cadherin_repeat 1557..1662 CDD:206637 17/113 (15%)
Blue background indicates that the domain is not in the aligned region.

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