DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and cdh23

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_999974.1 Gene:cdh23 / 407978 ZFINID:ZDB-GENE-040513-7 Length:3366 Species:Danio rerio


Alignment Length:2755 Identity:671/2755 - (24%)
Similarity:1073/2755 - (38%) Gaps:762/2755 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 GDVEKSSLSHHSE-MSLVLPHDTYPGFSIKKFKTHPVKINGSSHSGAAAYHMLDT--DYSKYFTV 120
            |||..::.|.::: .::.:|.:|..|.|:       ..:|.:.........:|.:  ..|::|::
Zfish   129 GDVNDNAPSFYNQPYAIQIPENTPVGTSV-------FMVNATDPDQGVGGSVLFSFQPPSQFFSI 186

  Fly   121 LED---GVVMTTADISPLVNRPVQLVVVEQTPNATNTH---------NLQLFVMHRNDM------ 167
              |   |:|..|..:........||.|     |||:..         ||.:.:....||      
Zfish   187 --DGARGIVTVTRALDYETTIAYQLTV-----NATDQDKRRPLSSLANLAITITDIQDMDPIFTN 244

  Fly   168 LRFSGSLLDASGEVRENQPAGTRVRGVPLMQAFSGSILDEELATPKKVRYTIIDGNVDDAFALQE 232
            |.:|.:::       |:.|.|..||.:        ..:|::|..|:.:.||||.||.:..|||. 
Zfish   245 LPYSTNIM-------EDAPPGYEVRKI--------RAIDQDLGRPRGIGYTIISGNTNSMFALD- 293

  Fly   233 RKANKNIQISAKSLVINGDDESGVWLVTNRPLDREERAH---YDLSVEASDVDGLDRTVSKIQIT 294
                   .||. ||.::|.            ||||...:   :.::|:|::::. |||.|...:|
Zfish   294 -------YISG-SLTVSGQ------------LDRENPLYSSGFIITVKATELND-DRTPSSATVT 337

  Fly   295 ------VLDENDNRPIFKSLDYKFAIAGQKSASMESNSSVTYQRFAIMGKVEATDAD-------- 345
                  ::|:|||.|.|.|.:|:..|           :.:....||:...::..|.|        
Zfish   338 TTFTILLIDKNDNPPRFNSSEYRVLI-----------TELAQVGFALPLYIQVEDKDEGVNSMFQ 391

  Fly   346 ----GDKIAYRLKSPSNVV--------IIVPQTGEI-------MLAGEPTSN-----ELLIEVI- 385
                |:...:...||::|.        :.:|...|.       :.|.|..|.     .:.|::| 
Zfish   392 VFLTGNNSDHFSISPTSVQGRADLRLRVAIPLDYETIRSYSFSLYANESLSEHVGFARVFIDLIN 456

  Fly   386 -----------AHDLRYPSLVSAKPAKVLLEFLAAE---PVSFIMQHLEHDDINNHSHHRE---- 432
                       .:::..|.  |.:|...||:..|.:   ....::::...|:.:..|...|    
Zfish   457 ENDNRPIFSQTLYNISLPE--SIEPGASLLQIKATDNDIGTFGVVRYYFSDEPDQFSLDAETGWV 519

  Fly   433 ----------KRRVTRAV--------RPTKRIEFTEADGDTEGKSVFQLE---------KETDKE 470
                      .||.|..:        ..|.|:.....|.: :...|||.|         ::..::
Zfish   520 TLRGRLDYELMRRFTLTILARDGGGEETTGRLRINVMDVN-DNAPVFQKEAYTGSLMENEQAPQQ 583

  Fly   471 TFKIR---DDNPWVTV--------------------ETNGAVRVKKKWDYEELGPEKTIDFWVII 512
            ..:.|   :|:|...:                    |....:.|.:..|||:: |...| |..::
Zfish   584 VIRARATDEDSPPNNILTYSIIYASQFRSFFSISIAEGYAVITVTRPLDYEQV-PGGLI-FLTLM 646

  Fly   513 TNMGHNAGIKYTDNQRVIILVKDVNDEPPYFINRPLPMQAVVQLNAPPN----TPVFTLQARDPD 573
            ...|.|..:..|  ..|||.:.|.||.||.|   .||...|   |.|.|    ..|..:.|.|.|
Zfish   647 AKDGGNPSLNST--VPVIIELIDQNDNPPEF---SLPSYIV---NIPENIVAGATVLFVNATDLD 703

  Fly   574 TDHNIHY--FIVRDRTGGRFEVDERSGVVRTRGTDLFQLDM--EYVLYVKAEDQNGKVDDRRFQS 634
            .......  .|...:...:|.::.|||.:.|  |.|...:|  ||:|.|:|.|  |.|..::...
Zfish   704 ASREFGQTSLIYSLQGSSQFRLNTRSGEITT--TALLDREMKSEYILIVRAVD--GGVGPQQKTG 764

  Fly   635 TPEERLSIVG-GKRAPQFYMPSYEAEIPENQKKDSDIISIKA--KSFADREIRYTLKAQGQGAGT 696
            .....::::. ...||.:....|:|.:.|....|:|:|::.|  ..:.|           .|...
Zfish   765 IATVNITVLDINDNAPVWRDEPYQANVVEMSPIDTDVITVFAVDPDYGD-----------NGTVV 818

  Fly   697 FNIGP---------------TSGIVKLAKELDFE--DLRQPHVYSLIVTATEDSG----GFSTSV 740
            ::|.|               |||.|     ||.|  |.|...:...|:.:..|.|    ..|.|.
Zfish   819 YSINPENPFYTINRNTGKIRTSGAV-----LDRESQDARSAQLMRTIIISATDRGTPPLRSSASA 878

  Fly   741 DLTIRVTDVNDNAPKF-ELPDYQAHNVDEDIPLGTSILRVKAMDSDSGSNAEIEYLVSDDHFAVD 804
            .:.:.:.|:|||.|.| .|| :.| .|.|.:|:|:|:.||:..|.|..:|..:...:......:|
Zfish   879 TVFVNLLDLNDNDPAFLNLP-FVA-EVPEGLPIGSSVFRVQVQDPDEAANGAVTMALQMGMPRLD 941

  Fly   805 -----SNGIIVNNKQLDADNNNAYYEFIVTAKDKGEPPKSGVATVRVYTKNKNDEEPKFSQQVYT 864
                 :.||:|:...||.:....||..|: |.|.|:.|::..:|:.:...:.|||.|.|...||.
Zfish   942 FRLNITTGILVSTVVLDREQIGQYYLRII-AYDAGQFPRTSTSTLTITVLDVNDETPTFFPSVYN 1005

  Fly   865 PNVDENAGPNTLVTTVVASDKD-GDNVRFG-FVGGGTSSGQFVIEDITGVIRLHNKAISLDKD-- 925
            .:::|:...:.||..:..:|.| |.|.... |:..|...|:|.:...|||:|   ..:.||::  
Zfish  1006 VSLEESVPRDYLVVRLNCTDNDAGLNAELSYFITAGNQDGKFSVGFRTGVVR---TVVGLDRETQ 1067

  Fly   926 -KYELNVTAMDDGSCCVNGDQTIHTSTAVVVVFITDVNDNKPVFKDCSTYYPKVEEGAPNGSPVI 989
             .|.|.:.|:|:|..   |.:  .|.||.|.|.:.|||||:|:|.. ::|...|.|..|.|:.::
Zfish  1068 ASYRLVIEAIDNGPA---GGR--RTGTATVYVEVLDVNDNRPIFLQ-NSYETSVLENIPRGTSIL 1126

  Fly   990 KVVATDEDKGVNGQVKYSIVQQPNQKGTKFTVDEETGEVSTNKV-FDREGDDGKFVSVTVKATDQ 1053
            :|.|||.|:|.||:|.|.|:...|   .:|::|..:|.:|...| .|||......:.|....:|.
Zfish  1127 QVQATDADQGENGKVLYRILSGNN---GQFSMDSLSGLISRGSVALDRETRSSNVLEVEAYNSDL 1188

  Fly  1054 GDPSLEGVCSFTVEITDVNDNPPLFDRQKYVE-NVKQDASIGTNILRVSASDEDADNNGAIVYSL 1117
            |  |:.......|.:.||||..|:|.:.:|.. .:::.|.|||:::.|.|:|.|..:.||:.|||
Zfish  1189 G--SMRSTVRVIVYVEDVNDEFPVFTQSQYNRLGLRETAGIGTSVVVVRATDPDTGDGGAVAYSL 1251

  Fly  1118 TA----------------------------------------PF--------------------- 1121
            .:                                        ||                     
Zfish  1252 VSGSDRKFEVDVSTGLLTTVDYLDYETKTSYLMNVSATDQSPPFHRSYCTVYVTLLNELDEAVAF 1316

  Fly  1122 ----------------------------NPNDLEY-------------FEIQAESGWIVLKKPLD 1145
                                        |.|.|.|             |:|.:.:|.|.:...||
Zfish  1317 LSAGYEVSLRENIATGTEVVQVKAQSADNLNQLSYRFDPDTSPAALALFKIDSVTGRITVTGLLD 1381

  Fly  1146 GCYPRDR---YRLRVSASDKGTPASAADVDVELDVVDRNNKPPIWDKSIYGPIHIRENVTVGTVV 1207
                |:|   |.|.|.|.| |.|...:.|.|.:.::|.|:..|.:|.:....::|.|:..:|..|
Zfish  1382 ----RERGDSYTLTVVADD-GGPKRGSTVKVSITILDENDNSPEFDITSDLSVNIPEDTAIGKRV 1441

  Fly  1208 TSVKASSGIEG-NPTVFYRLMPGSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEYNL 1271
            ..|.|.....| |..|.:.|:.|:.....|.:|.        .:|:.::.:|.|||.||:..|.|
Zfish  1442 AVVLARDKDAGRNGLVNFTLIAGNMQDVFKINTV--------NNTYGEVYLNAPLDRESVDRYLL 1498

  Fly  1272 TIRVENNGAQQLASEATVYIMLEDVNDEIPLFTEREQETVLEGEPI--GTKVTQVNAIDKD-GTF 1333
            .:|..:||:....::.::.:.:.||||..|:........|...|.:  ||.|.:|.|.|:| |. 
Zfish  1499 KVRAMDNGSPPRYTDVSLTVNIVDVNDNPPVLQSPRGYNVSVSENVGGGTSVLRVVATDRDIGA- 1562

  Fly  1334 PNNQVYYYIVDSPRNEGKE--FFEINLQSGEIFTK-TVFDREKKGAYALEVEAR-DGAPSARPNS 1394
             |..:.|||     ..|.:  .|.::..:|||.|: :..||||:..|.|.|... ||.|:.    
Zfish  1563 -NAMLSYYI-----TAGNQDLTFRMDRMTGEIVTRPSPPDREKQQQYTLTVTVEDDGTPTL---- 1617

  Fly  1395 NGPNSVTKFIRIGIADKNDNPPYFDKSLYEAEVDENED-IQHTVLTVTAKDHDE--SSRIRYEIT 1456
              ..|.|.::|  |.|:|||.|.|.:..|..|:.|..: :...:.||||.|.||  :..|||.|:
Zfish  1618 --STSTTVWVR--IIDENDNAPEFPEEEYVTELREGPNTVGAIIATVTAIDPDEGLNGTIRYAIS 1678

  Fly  1457 SGNIGGAFAVKNMTGAIYVAGALDYE-TRRRYELRLAASDNLK------ENYTTVIIHVKDVNDN 1514
            .||:...|.:.::||.|.|..||||| :...|.|.:.|:|...      .:.|||:::|.|||||
Zfish  1679 KGNLAQTFQINSVTGQIVVVSALDYEISNGHYVLTVTATDQCPIPLLRLTSSTTVLVNVIDVNDN 1743

  Fly  1515 PPVFERP---------------------------------------------------------- 1521
            ||:|.||                                                          
Zfish  1744 PPIFPRPFEGPFEITEGQPGPRVWTVKATDADSGSNGKVEYSITAGDLKNEFVISSVEGELRVRK 1808

  Fly  1522 ----------TYRTQITEED--------------------DR-----NLPKR------------V 1539
                      .|...||.:|                    |.     |||..            :
Zfish  1809 DIELDRETIAYYNITITAKDLGTPSLNATVVVGILVLDINDNDPILLNLPANTSVSEGAAVQTFI 1873

  Fly  1540 LQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTV 1604
            :||.|.|.|..|...:.|.:|....|      ..|.||.|:|.:.|.:||||::.   .::..|:
Zfish  1874 IQVRAQDSDSGRNALLTYSITAGNSD------GAFYINETSGVVQVNRPLDRERV---AEYSLTI 1929

  Fly  1605 FAQDEGGEGLVGYAD---VQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTA-VDYDDPN 1665
            ..:|......:...|   :.|.|.|:|||.|||.|..|.|.::||...|..|:.:.. |..:|.:
Zfish  1930 TVKDNPDNPRIARRDSELLTVTLLDVNDNRPIFSQSSYRGEISENSPTGTTVLILNGPVLAEDKD 1994

  Fly  1666 EGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKT---AVCCLDRE--RTPDYSIQVVAMDGGG 1725
            .|.||.:.|.:....::      ||.|:..|||:..   ||  ||||  ..|...:.:|::|.||
Zfish  1995 IGVNAVVSYGLLGTRVD------IFSIDSRTGVVSVRGGAV--LDREAFSVPRVELFLVSVDVGG 2051

  Fly  1726 LKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKVIDNS 1790
            |..:...:|.:.|:||.||.|....:...:.|...|.: .:..|:.|..|.......||::  :|
Zfish  2052 LNSSVPLTITILDVNDNPPVFNPSSFTVRLPENSPTGV-VVTQLSATDADAGSNGWLQYRL--DS 2113

  Fly  1791 GYGADKFTMVRNNDGTGSLKIV--QPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVV 1853
            | ..|:|.:    |......:|  ..||.|::   :.:|..:...|:|..:.:     ..:.:.|
Zfish  2114 G-AQDRFIV----DALSGAVLVGNATLDREER---SSYRLVVIATDRGTPSLS-----GTATLTV 2165

  Fly  1854 KLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSY---SIDRSSD------ 1909
            .|.|:||::|.|.:....:||.|.|..|..:....|.|||.  |.::.|   |::...|      
Zfish  2166 VLDDVNDSRPRFIQPVQTISVNESTPPGVVVATLAAEDPDL--KPRLEYYIISVEAKDDGNNAVD 2228

  Fly  1910 -RQRQFAIN-QNGSVTIQRSLDREVVPRHQVKILAIDDGS-----PPKTATATLTVIVQDINDNA 1967
             .|:.|.|: ..|:|.::..|:||:|...::.:...|:.|     ......|.||:.|.|:||||
Zfish  2229 GLQQSFGIDFHTGAVFVRNPLNRELVATFEIIVSVHDNASDVIEMSVSVPNAKLTINVLDVNDNA 2293

  Fly  1968 PKFLKDYRP---------VLPEHVPPRKVVEILATDDDDRSKSNGPPFQ-------------FRL 2010
            |:|    ||         :|...||...::.:.|.|.|     .||..|             .||
Zfish  2294 PRF----RPFGVANFSESILEGAVPGTTLLSVTAVDPD-----KGPNGQIIYQLLNLPRGNYIRL 2349

  Fly  2011 -DPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLT 2074
             |||...|:            ||          |:.|.||.:.....:..:|||||.......:.
Zfish  2350 EDPSTGKIV------------AN----------RTVDFEQVQWLNFTVRAQDHGSPPRFTELPVY 2392

  Fly  2075 VIIGDVNDNK---MQP-GSKDIF--------VYNYQGQSPDTPIGRVYVYDLDDWDLPDKKFYWE 2127
            :.|.|||||.   .|| ..|.||        :.:.:....|:.:..|..|.|.|.:         
Zfish  2393 LRIIDVNDNNPVFQQPLYQKSIFEDVALGTIIVSVRATDADSGLFSVIEYGLVDGE--------- 2448

  Fly  2128 AMEHPRFKLDEDSG-MVTMRAGTREGRYHLRFKVYDRKHTQTDIPANVTVTVREIPHEAVVNSGS 2191
                .:|.:...:| :..:.|..||.:.......|.|     |.|.......||       ||..
Zfish  2449 ----GKFGITPTTGDIYILSALDRETKDRYTLTAYAR-----DNPGGSPNNRRE-------NSVQ 2497

  Fly  2192 VRLSGISDEDFIRVWNYR--TQS-------------MSRSKMDRFRDKL---------AD----- 2227
            |:|:.:...||...::.|  |.|             |..:.:|...:.|         ||     
Zfish  2498 VQLTVLDVNDFRPRFSERVFTTSVFENEPVGTSVITMKATDLDEGENALLTYSLQGPGADAFSLD 2562

  Fly  2228 -----------LLNTERENVDIFSVQLKRKHPPL--------TDVRFSAHGSPYYKPVRLNGIVL 2273
                       |.:.||.|:.:.:....|  |||        |.:..:.:...:.:|.  ||.::
Zfish  2563 PDTGLIRSLRLLQSFERFNLTVVATDQGR--PPLWGTASLQITVIDVNDNRPIFVRPA--NGTIM 2623

  Fly  2274 MHREE------------IEKDVGIN 2286
            ...||            .::|.|:|
Zfish  2624 HILEEQPPGLVVYEVFATDEDEGVN 2648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637 35/131 (27%)
Cadherin_repeat 337..396 CDD:206637 14/102 (14%)
E_set 449..541 CDD:298831 25/123 (20%)
Cadherin_repeat 549..>625 CDD:206637 24/83 (29%)
Cadherin_repeat 655..752 CDD:206637 27/119 (23%)
Cadherin_repeat 765..853 CDD:206637 24/92 (26%)
Cadherin_repeat 862..964 CDD:206637 33/106 (31%)
Cadherin_repeat 973..1074 CDD:206637 33/101 (33%)
Cadherin_repeat 1083..1166 CDD:206637 34/188 (18%)
Cadherin_repeat <1219..1298 CDD:206637 20/78 (26%)
Cadherin_repeat 1310..1414 CDD:206637 36/110 (33%)
Cadherin_repeat 1423..1514 CDD:206637 37/100 (37%)
Cadherin_repeat 1522..1630 CDD:206637 34/147 (23%)
Cadherin_repeat 1638..1741 CDD:206637 32/108 (30%)
Cadherin_repeat 1762..1861 CDD:206637 21/100 (21%)
Cadherin_repeat 1871..1966 CDD:206637 30/110 (27%)
Cadherin_repeat 1974..2083 CDD:206637 32/131 (24%)
EGF 2350..2380 CDD:278437
LamG 2385..2570 CDD:238058
EGF_2 <2605..2631 CDD:285248
Laminin_G_2 2665..2800 CDD:280389
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
cdh23NP_999974.1 Cadherin_repeat 48..134 CDD:206637 3/4 (75%)
Cadherin_repeat 142..237 CDD:206637 20/108 (19%)
Cadherin_repeat 246..350 CDD:206637 36/140 (26%)
Cadherin_repeat 358..460 CDD:206637 17/112 (15%)
Cadherin_repeat 469..561 CDD:206637 15/94 (16%)
Cadherin_repeat 570..671 CDD:206637 19/104 (18%)
Cadherin_repeat 679..778 CDD:206637 25/105 (24%)
Cadherin_repeat 786..890 CDD:206637 27/119 (23%)
Cadherin_repeat 898..994 CDD:206637 26/98 (27%)
Cadherin_repeat 1003..1102 CDD:206637 33/106 (31%)
Cadherin_repeat 1110..1206 CDD:206637 32/100 (32%)
Cadherin_repeat 1221..1311 CDD:206637 15/89 (17%)
Cadherin_repeat 1321..1417 CDD:206637 23/100 (23%)
Cadherin_repeat 1428..1526 CDD:206637 28/105 (27%)
Cadherin_repeat 1536..1633 CDD:206637 36/111 (32%)
Cadherin_repeat 1641..1743 CDD:206637 37/101 (37%)
Cadherin_repeat 1755..1850 CDD:206637 4/94 (4%)
Cadherin_repeat 1858..1958 CDD:206637 27/108 (25%)
Cadherin_repeat 1966..2068 CDD:206637 33/109 (30%)
Cadherin_repeat 2076..2172 CDD:206637 22/111 (20%)
Cadherin_repeat 2181..2292 CDD:206637 30/112 (27%)
Cadherin_repeat 2304..2401 CDD:206637 30/123 (24%)
Cadherin_repeat 2410..2507 CDD:206637 23/121 (19%)
Cadherin_repeat 2516..2610 CDD:206637 16/95 (17%)
Cadherin_repeat 2624..2722 CDD:206637 5/25 (20%)
Cadherin_repeat 2738..2849 CDD:206637
Cadherin_repeat 2858..2959 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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