DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and naa20

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_989110.1	Gene:	naa20 / 394715	XenbaseID:	XB-GENE-969863	Length:	178	Species:	Xenopus tropicalis

Alignment Length:	198	Identity:	41/198 - (20%)
Similarity:	63/198 - (31%)	Gaps:	70/198 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  2840 PFECVDL--------------------------WNVY----ECTCGE--GRIMSPDSKGCMDRNE 2872
            ||.|.||                          |..|    |...||  |.||. .::|.:.|.|
Frog     6 PFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMG-KAEGSVAREE 69

  Fly  2873 CLDMPCMNG-ATCINLEPRLRYRCICPDGFWGENCELVQEGQTLKLSMGALAAILVCLLIILILV 2936
                  .:| .|.:::.|..|..     |...:..||::|....|      ....|.|.:.:...
Frog    70 ------WHGHVTALSVAPEFRRL-----GLAAKLMELLEEISERK------GGFFVDLFVRVSNQ 117

  Fly  2937 LVFVVYNRRREAHIKYPGPDDDVRENIINYDDEGGGEDDMTAFDITPLQ---------IPIGGPM 2992
            :...:|.:     :.|     .|...:|.|.....||.|..|:|:....         :|:..|:
Frog   118 VAVNMYKQ-----LGY-----SVYRTVIEYYSASNGEPDEDAYDMRKALSRDTEKKSIVPLPHPV 172

  Fly  2993 PPE 2995
            .||
Frog   173 RPE 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011	7/38 (18%)
		Cadherin_C	2952..3088	CDD:279398	13/53 (25%)
naa20	NP_989110.1	RimI	1..156	CDD:223532	37/177 (21%)
naa20	NP_989110.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..178		4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3CNY1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860