DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and Cdh19

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001009448.1	Gene:	Cdh19 / 360835	RGDID:	1307169	Length:	770	Species:	Rattus norvegicus

Alignment Length:	592	Identity:	163/592 - (27%)
Similarity:	282/592 - (47%)	Gaps:	65/592 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1527 ITEEDDRNLPKRVLQVTATDGDKDRPQN-IVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLD 1590
            :.||.|     .:..|.....|.|...| ..|.|.|.|       :..|.|:..||:||.::.||
  Rat    52 VPEEMD-----TIQHVGRLRSDLDNGNNSFQYKLLGTG-------DGSFSIDEKTGDIFAMQKLD 104

  Fly  1591 RDQPNGRPQWRFTVFAQ---DEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMV 1652
            |::     |..:.:.||   ...|:.:...::..:.:.|:|||.|.|....|...|.|....|..
  Rat   105 REK-----QSLYILRAQVIDTTIGKAVEPESEFVIRVSDVNDNEPRFLDEPYEAIVPEMSPEGTF 164

  Fly  1653 VMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQ 1717
            |:.:||.|.|||..|.:||::|::|:       |.|.|.:||.||||:.: ..:|||....|.:.
  Rat   165 VIKVTANDADDPTSGYHARILYNLEQ-------GQPYFSVEPTTGVIRIS-SKMDRELQDTYCVI 221

  Fly  1718 VVAMD----GGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDET--DGTALPEMPILTVTVHDE 1776
            :.|.|    .|.|.||.|.||::.||||..|.|.:..:...:.|:  .||.:.:     :..:|:
  Rat   222 IQAKDMLGQPGALSGTTTISIKLSDINDNKPIFKESFYRFTISESAPSGTTIGK-----IMAYDD 281

  Fly  1777 D--ETNKFQYKVIDNSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDN 1839
            |  |..:..|.:.|:.....|  .::.|....|.:.:.:.:|:|.|   |.:..|::|.:...|.
  Rat   282 DIGENAEMDYSIEDDESQIFD--IVIDNETQEGIVILKKKVDFEHQ---NHYGIRVKVKNCHVDE 341

  Fly  1840 DNDKYHVAYSWVVVKLR-DINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYS 1903
            :....||..|...:|:: :..|..|.|........:.|....||.:....|.|||: .:|.:.||
  Rat   342 ELAPAHVNASTTYIKVQVEDEDEPPTFLLPYYIFEIPEGKPYGTMVGTVSAVDPDR-RQSPMRYS 405

  Fly  1904 IDRSSDRQRQFAINQNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAP 1968
            :..|    :.|.||.||::.....|||||...:.:.:.|.:..:..:.::|.:.|.|.:|||:||
  Rat   406 LIGS----KMFDINGNGTIVTTNLLDREVSAWYNLSVTATETYNVQQISSAHVYVQVLNINDHAP 466

  Fly  1969 KFLKDYRPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANG 2033
            :|.:.|...:.|:....::::.::..|.|.|..:   ..|..:.|.:|...:||.:..:|
  Rat   467 EFSQLYETYVCENAESGEIIQTISAIDRDESIED---HHFYFNHSVEDTNNSSFILTDNQ----- 523

  Fly  2034 DGMAVISSLRS-FDREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQP--GSKD-IFV 2094
            |..|||.|.|: |..:::..:.:.|:|.|:|.|.:|.|:|||:.:.|..|::...  .||: :|:
  Rat   524 DNTAVILSNRAGFSLKEETVFYMIILIADNGIPPLTSTNTLTIQVCDCGDSRSTETCTSKELLFI 588

  Fly  2095 YNYQGQS 2101
            ..::.::
  Rat   589 MGFKAEA 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	26/106 (25%)
		Cadherin_repeat	1638..1741	CDD:206637	40/106 (38%)
		Cadherin_repeat	1762..1861	CDD:206637	19/101 (19%)
		Cadherin_repeat	1871..1966	CDD:206637	27/94 (29%)
		Cadherin_repeat	1974..2083	CDD:206637	29/109 (27%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Cdh19	NP_001009448.1	Cadherin_repeat	49..142	CDD:206637	26/106 (25%)
		Cadherin_repeat	150..250	CDD:206637	41/107 (38%)
		Cadherin_repeat	259..364	CDD:206637	22/114 (19%)
		Cadherin_repeat	373..464	CDD:206637	27/95 (28%)
		Cadherin_repeat	472..570	CDD:206637	28/105 (27%)
		Cadherin_C	617..764	CDD:395833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5067
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910