DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and mep1bb

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_009294699.1	Gene:	mep1bb / 327586	ZFINID:	ZDB-GENE-030131-5797	Length:	774	Species:	Danio rerio

Alignment Length:	311	Identity:	69/311 - (22%)
Similarity:	108/311 - (34%)	Gaps:	73/311 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  2117 WDLPDKKFYWE------AMEHPRFKLDEDSGMVTMRAGTREGRYHLRFKVYDRKHTQTDIPANVT 2175
            |.:.|.|...|      |:..|||         |.|.|     |..:..:|  .:.....|..:.
Zfish   445 WIVRDFKSILENTPMDTAIYSPRF---------TSRLG-----YSFQMGLY--PNGTAGNPGEMG 493

  Fly  2176 VTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMS------RSKMDRFRDKLADLLNTERE 2234
            .....:..:|.|:.|.|         :...|...|..|.      |.:|...|....|...|...
Zfish   494 AYAHLVSGDAAVDGGLV---------WPAQWKQMTMMMMDQNADIRRRMSNQRSVTTDPNMTVEG 549

  Fly  2235 NVDIFSVQLKRKHPPLTDVRFSAHGSPYYK------PVRLNGIVLMHREEIE-KDVGINITMVGI 2292
            ::::|....::....:||    .:|:.|::      ||.|.....:.|:.|: .|....:||..|
Zfish   550 SLNLFWDDPRKVGVKVTD----DNGTEYFRGPGAGTPVYLTQARALSRDFIKGGDAIFLLTMEDI 610

  Fly  2293 DECLYENQMCEGSCT-------------NSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNF 2344
            .:.:....:...:.|             ||...||..:..:...|:   ....|.:..|..:.:.
Zfish   611 SDLVASQPLPSTTVTPATSAHTGPTNPDNSTTASPATHTSSITHTS---ADTHTSSSTTSSSSST 672

  Fly  2345 T--KPESCRTTPCHNGGRCVDTRFG-PHCSCPVG----YTGPRCQ--QTTR 2386
            |  .|:.|.:..|.|.|.||....| |.|.|.||    |.|.|||  .:||
Zfish   673 TVPPPDPCVSLQCENDGVCVQDDAGQPVCRCAVGSDWWYYGERCQHKSSTR 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	14/34 (41%)
		LamG	2385..2570	CDD:238058	2/2 (100%)
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
mep1bb	XP_009294699.1	ZnMc	39..267	CDD:294052
		Astacin	81..269	CDD:279708
		MAM	277..441	CDD:279023
		MAM	277..440	CDD:99706
		MATH	440..608	CDD:295307	38/191 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910