DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Cdh10

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001303687.1	Gene:	Cdh10 / 320873	MGIID:	107436	Length:	788	Species:	Mus musculus

Alignment Length:	546	Identity:	167/546 - (30%)
Similarity:	278/546 - (50%)	Gaps:	60/546 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1548 DKDRPQ-NIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQDEGG 1611
            |:|:.. ::.|.|:|.|      |.:.|.|:..||:|...:.:||::     :..:|:.||....
Mouse    81 DQDKGDGSLKYILSGDG------AGTLFIIDEKTGDIHATRRIDREE-----KAFYTLRAQAINR 134

  Fly  1612 EGL---VGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLV 1673
            ..|   ...::..:.:.|||||.|.||:.:|..:|.|....|..|:.:||.|.|||:.|::||::
Mouse   135 RTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVI 199

  Fly  1674 YSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASI 1734
            |||.:       |.|.|.:||:||:|:||:..::||....|.:.:.|.|    .|||.||.|.:|
Mouse   200 YSILQ-------GQPYFSVEPETGIIRTALPNMNRENKEQYQVVIQAKDMGGQMGGLSGTTTVNI 257

  Fly  1735 RVKDINDMPPQFTKDEWFTEVDETD--GTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGADKF 1797
            .:.|:||.||:|.::.....|.|:.  |||:..   :..|..|..:..:..|::||  |.|.|.|
Mouse   258 TLTDVNDNPPRFPQNTIHLRVLESSPVGTAVGS---VKATDADTGKNAEVDYRIID--GDGTDMF 317

  Fly  1798 TMVRNND-GTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVA----YSWVVVKLRD 1857
            .::...| ..|.:.:.:|||||     |...:.::|..:....|...|::.    .:.|.:.:.|
Mouse   318 DIITEKDTQEGIITVKKPLDYE-----NRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIED 377

  Fly  1858 INDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQ-NGS 1921
            : |..|.|.|::....|.||.:|||.:....|.||| ...|.:.:::||.:|..|.|.|:. |||
Mouse   378 V-DEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPD-STSSPIRFTLDRHTDLDRIFNIHSGNGS 440

  Fly  1922 VTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRK 1986
            :...:.||||:...|.:.::|.:..:|.:|...::.|.:.|:|||||:|...|...:.|:..|.:
Mouse   441 LYTSKPLDRELSQWHNLTVIAAEINNPKETTRVSVFVRILDVNDNAPQFAVFYDTFVCENARPGQ 505

  Fly  1987 VVE-ILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMA-VISSLRSFDREQ 2049
            ::: |.|.|.||  ...|..|.|.|     ..:..:|.|:.     |.|..| :::....|:|.:
Mouse   506 LIQTISAVDKDD--PLGGQKFFFSL-----AAVNPNFTVQD-----NEDNTARILTRKNGFNRHE 558

  Fly  2050 QKEYMIPIVIKDHGSPAMTGTSTLTV 2075
            ...|::|:||.|:..|..:.|.|||:
Mouse   559 ISTYLLPVVISDNDYPIQSSTGTLTI 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	21/85 (25%)
		Cadherin_repeat	1638..1741	CDD:206637	40/106 (38%)
		Cadherin_repeat	1762..1861	CDD:206637	23/103 (22%)
		Cadherin_repeat	1871..1966	CDD:206637	31/95 (33%)
		Cadherin_repeat	1974..2083	CDD:206637	29/104 (28%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Cdh10	NP_001303687.1	CA	80..158	CDD:214520	23/87 (26%)
		Cadherin_repeat	164..265	CDD:206637	41/107 (38%)
		Cadherin_repeat	273..380	CDD:206637	27/117 (23%)
		Cadherin_repeat	388..485	CDD:206637	31/97 (32%)
		Cadherin_repeat	493..587	CDD:206637	29/104 (28%)
		Cadherin_C	643..780	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910