DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Cdh18

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001074768.1	Gene:	Cdh18 / 320865	MGIID:	1344366	Length:	790	Species:	Mus musculus

Alignment Length:	590	Identity:	180/590 - (30%)
Similarity:	283/590 - (47%)	Gaps:	109/590 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1521 PTYRTQITEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFV 1585
            |.|..::....|:.           ||      ::.|.|||:|      |.:.|.|:.|||:|..
Mouse    71 PQYVGKLHSNSDKG-----------DG------SVKYILTGEG------AGTIFIIDDTTGDIHS 112

  Fly  1586 LKPLDRDQPNGRPQWRFTVFAQ---DEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENG 1647
            .|.|||:|     :..:.:.||   ....:.|...::..:.::|||||||.|..|.|...|.|..
Mouse   113 TKSLDREQ-----KTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMS 172

  Fly  1648 TAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTP 1712
            ..|..|:.:||.|.|||..|::||:||||.:       |.|.|.::|.||||:||:..:|||...
Mouse   173 DMGTSVLQVTATDADDPTYGNSARVVYSILQ-------GQPYFSVDPKTGVIRTALHNMDREARE 230

  Fly  1713 DYSIQVVAMD----GGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETD--GTALPEMPILTV 1771
            .||:.:.|.|    .|||.|:.|.:|.:.|:||.||:|.:..:...|.|:.  |:|:.:     :
Mouse   231 HYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVGSAVGK-----I 290

  Fly  1772 TVHDEDETNKFQYKVIDNSGYGADKFTMVRNNDG-------------TGSLKIVQPLDYEDQ--- 1820
            ..:|.|            :|..||....:.|.||             .|.|.:.:||:||.:
Mouse   291 KANDAD------------TGSNADMTYSITNGDGIGVFSISTDKDTREGILSLKKPLNYEKKKSY 343

  Fly  1821 -LQSNG------FRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDT 1878
             |...|      |||    :..|...|       .:.:.|.:.|: |..|.|...:..:.|:|:.
Mouse   344 TLNIEGANTHLDFRF----SHLGPFKD-------ATMLKVIVGDV-DEPPLFSMPSYVMEVYENA 396

  Fly  1879 KVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQN-GSVTIQRSLDREVVPRHQVKILA 1942
            |:||.:....|.||| ...|.|.|.|:.|::.:|.|.|:.| |::...:.||||..|.:.:.:.|
Mouse   397 KIGTIVGTVLAQDPD-SANSLVRYFINHSTEEERFFNIDANTGTIKTSKVLDREETPWYNITVTA 460

  Fly  1943 IDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVE-ILATDDDDRSKSNGPPF 2006
            .::.:|...:..::.:.|.|:|||.|:..::|..|:.|:..|.:|:. |.|||.||  .:|||.|
Mouse   461 SENDNPDLLSHVSVGIRVLDVNDNPPELAREYDIVVCENSKPGQVIHTITATDKDD--FANGPRF 523

  Fly  2007 QFRLDPSADDIIRASFKVEQDQKGANGDGMA-VISSLRSFDREQQKEYMIPIVIKDHGSPAMTGT 2070
            .|.||....  :..:|.::.     |.|..| :::..|.|.|..|..|.:||:|.|.|.|:::.:
Mouse   524 HFFLDERLP--MNPNFTLKD-----NEDNTASILTRRRRFSRTMQDVYYLPIMISDGGIPSLSSS 581

  Fly  2071 STLTV 2075
            ||||:
Mouse   582 STLTI 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	27/110 (25%)
		Cadherin_repeat	1638..1741	CDD:206637	42/106 (40%)
		Cadherin_repeat	1762..1861	CDD:206637	24/121 (20%)
		Cadherin_repeat	1871..1966	CDD:206637	29/95 (31%)
		Cadherin_repeat	1974..2083	CDD:206637	37/104 (36%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Cdh18	NP_001074768.1	CA	79..157	CDD:214520	28/105 (27%)
		Cadherin_repeat	163..264	CDD:206637	43/107 (40%)
		Cadherin_repeat	272..379	CDD:206637	27/135 (20%)
		Cadherin_repeat	387..484	CDD:206637	29/97 (30%)
		Cadherin_repeat	491..589	CDD:206637	37/105 (35%)
		Cadherin_C	637..783	CDD:395833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910