DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and Crb1

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001100652.1	Gene:	Crb1 / 304825	RGDID:	1309947	Length:	1407	Species:	Rattus norvegicus

Alignment Length:	696	Identity:	169/696 - (24%)
Similarity:	264/696 - (37%)	Gaps:	147/696 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  2255 FSAHGSPYYKPVRLNGIVLMHREEIEKDVGINITMVGIDECLYENQMCEGSCTNSLEISPLPYMV 2319
            ||..|:..|..:.|.|....|.||            .|||||....:..|:|.|      ||
  Rat   374 FSYLGASGYVCICLPGFTGRHCEE------------DIDECLPNPCLNGGTCQN------LP--- 417

  Fly  2320 NANKTALVGVRVDTIADCTC----GARNFTKPESCRTT-------PCHNGGRCVDTRFGPH---- 2369
             .|.|            |.|    .:|.|...|.|...       .|.|.|:|:     ||
  Rat   418 -GNYT------------CHCPFDDTSRTFYGGEDCSEILLGCTHHQCLNNGKCI-----PHFQNG 464

  Fly  2370 -----CSCPVGYTGPRCQQ-TTRSFRGNGWAWYPP---LEMCDESHLSLEFITRKPDGLIIYNGP 2425
                 |.||.||.||.|:. ||.||..||:.|...   ..|..|.::||:|.|.:|:.|::..|
  Rat   465 QHEFTCQCPSGYAGPLCETVTTLSFESNGFLWVTSGSHTSMGSECNISLKFQTVQPNALLLVRG- 528

  Fly  2426 IVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDL-FWDTESIRM 2489
                .:|.:     :.|||..|...|.|:..:.:..|...:..| .|||||.::: |.:|.::.:
  Rat   529 ----NKDMS-----VKLELLDGCVHLSIEVWNQSKVLLYISHNT-SDGEWHLVEVTFAETITLAL 583

  Fly  2490 VVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGLYREQFDQSLYFW--H 2552
            ....||  |....:.....|.....|..:      |.:|        |||.......|:...  :
  Rat   584 NGSSCK--EKCTTKSSVSIENHQSICALQ------NSFL--------GGLPMGTASDSMSVLNIY 632

  Fly  2553 YMPTAKGFDGCIRNLVHNSKLYDLAH-------PGLSRNSVAGCPQTEEVCAQTETTARCWEHGN 2610
            .:|:...|.||::::     .:||.|       .|||.|..|||.:.:...:|.     |...|.
  Rat   633 NVPSTPSFVGCLQDI-----RFDLNHITLESISSGLSSNVKAGCLRKDWCESQP-----CQNRGR 687

  Fly  2611 CVGSLSEARCHCRPGWTGPACNIPTIPTTFKAQSYVKYALSFEPDRFSTQVQLRF--RTREEYGE 2673
            |:......||.|...:.|..|....:...|.......||.....|.|.....|..  |||:..|.
  Rat   688 CINLWQGYRCECDRPYAGSNCLKEYVAGRFGQDDSTGYAAFKVNDNFGQNFNLSMFVRTRQPLGF 752

  Fly  2674 LFRVSDQHNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLE 2738
            |..:.:. ..:|..:.::.|.|       :|:|......:....::||..|::         :|.
  Rat   753 LLTLGNS-TYQYVCVWLEHGSL-------ALKTPGSPKLVANFFLSDGNAHLI---------SLR 800

  Fly  2739 LDGGEGRRY--NETFEFVGHQWLLVDKQEGVYAGG--KAEYTGVRTFEVYADYQKSCLDDIRLEG 2799
            :...|...|  ::...|:......:.:.:.::.||  ..|.|     |.|..:.|.|:.|:||..
  Rat   801 IKPNEIELYQSSQNLGFMSVPAWTIQRGDVIFIGGLPDREKT-----EAYGGFLKGCIQDVRLNS 860

  Fly  2800 KHLP-LPPAMNGTQWGQATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRIMSPD 2863
            ::|. .|.:.|..|.....:  |:.:|||.:..|.:..|.:...|..||:.:.|:|.    .:..
  Rat   861 QNLEFFPNSTNSAQHDPVLV--NVTQGCPGDNVCKSNPCHNGGVCHSLWDDFSCSCP----TNTS 919

  Fly  2864 SKGCMDRNECLDMPCMNGATCINLEPRLRYRCICPDGFWGENCELV 2909
            .:.|.:...|...||...|.| .|.|: .:.||....|.|.:.|::
  Rat   920 GRACDEVQWCQLSPCPPIAEC-QLVPQ-GFECIANAAFSGLSSEIL 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	13/45 (29%)
		LamG	2385..2570	CDD:238058	46/190 (24%)
		EGF_2	<2605..2631	CDD:285248	7/25 (28%)
		Laminin_G_2	2665..2800	CDD:280389	28/140 (20%)
		EGF_CA	2869..2907	CDD:238011	11/37 (30%)
		Cadherin_C	2952..3088	CDD:279398
Crb1	NP_001100652.1	EGF_CA	73..108	CDD:238011
		EGF	115..145	CDD:278437
		EGF_CA	149..184	CDD:238011
		EGF_CA	188..223	CDD:238011
		EGF_CA	226..261	CDD:238011
		EGF_CA	263..300	CDD:238011
		EGF_CA	<310..338	CDD:238011
		EGF_CA	340..396	CDD:238011	7/21 (33%)
		EGF_CA	398..>425	CDD:214542	13/48 (27%)
		Laminin_G_2	515..650	CDD:280389	36/166 (22%)
		EGF_CA	677..708	CDD:238011	8/35 (23%)
		Laminin_G_2	744..861	CDD:280389	28/138 (20%)
		EGF	892..921	CDD:278437	7/32 (22%)
		LamG	955..1103	CDD:238058	3/9 (33%)
		EGF_CA	<1147..1176	CDD:238011
		EGF_CA	1178..1213	CDD:238011
		EGF_CA	1298..1334	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910