DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and LOC304725

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001316828.2	Gene:	LOC304725 / 304725	RGDID:	1592077	Length:	1293	Species:	Rattus norvegicus

Alignment Length:	1237	Identity:	225/1237 - (18%)
Similarity:	369/1237 - (29%)	Gaps:	458/1237 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  2016 DIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKD---------HGSPAMTGTS 2071
            |:|...||..|      |||:.       |..|.|:...|.:.:::         ....|...:.
  Rat   203 DVISLKFKSMQ------GDGVL-------FHGEGQRGDHITLELQNGRLVLYLNLDDKKAWLSSI 254

  Fly  2072 TLTVIIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYVYDLDDWDLPDKKFYWEAMEHPRFKL 2136
            |.:.|:|.:.|::..   ..:|:..         :|:...:.:|    .:.:.:|...|.....:
  Rat   255 TPSAILGSLLDDQHW---HSVFLER---------VGKQVNFTVD----RNTQHFWTKGETEVLDI 303

  Fly  2137 DEDSGM----VTMRAGT---------REGRYHLRFKVYD----RKHTQTDIPANVTVTVRE--IP 2182
            |.:...    |..:.||         .|..|:....:.|    ||| |.....|||.:..|  |.
  Rat   304 DYELSFGGIPVPSKPGTFVKKNFHGCIENLYYNGVNIIDLAKRRKH-QIYSVGNVTFSCSEPQIV 367

  Fly  2183 HEAVVNS--------GSVRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDKLADLLNTE-RENVDI 2238
            ....|||        |:.::.|:|.....|.||              .|.|  ||:|| .|....
  Rat   368 PITFVNSRSSYLFLPGTPQIDGLSVSFQFRTWN--------------EDGL--LLSTELSEGSGT 416

  Fly  2239 FSVQLKRKHPPLTDVRFSAHGSPYYK--------------PVRLNGIVLMHREEIEKD-VGINIT 2288
            ..:.|:.....|...:.:.||:....              .||.|.:.|    .::.| |.:...
  Rat   417 LLLILESGTLRLLIKKVTGHGTESLTGRSLNDGRWHSVSINVRRNRVTL----TVDNDAVSLAPE 477

  Fly  2289 MVGIDECLYE-NQMCEGSCTNSLEISP-------------LPYMVNANKTALVGVRVDTIADCT- 2338
            ..|:.  :|. |....|.|.::|.:|.             |.::.|..|. |:.|:..::.:.:
  Rat   478 TSGLQ--IYSGNSYYFGGCPDNLTVSQCLNPIKAFQGCMRLIFIDNQPKD-LISVQQGSLGNFSD 539

  Fly  2339 -----CGARNFTKPESCRTTPCHNGGRCVDTRFGPHCSC-PVGYTGPRC-----QQTTRSFRGNG 2392
                 |..:     :.|....|.:||.|..|....:|:| ..||||..|     :|:...:|..|
  Rat   540 LHIDLCSIK-----DRCLPNYCEHGGHCTQTWTSFYCNCSDTGYTGATCHNSIYEQSCEIYRHRG 599

  Fly  2393 ----------------------------------------------------------------- 2392

  Rat   600 NKAGFFYVDSDGSGPLGPLQVYCNVTEDKIWMTVQHTITELTQVQGSNSEKPYAMTLNYGGSMEQ 664

  Fly  2393 ----------------------------------------------WAWYPP---------LEMC 2402
                                                          |..|.|         .|.|
  Rat   665 LEALIDGSEHCEQEVTYRCRRAHLFNTQDEAPFTWWIGRSNERHPYWGGYVPGVQQCGCGLEESC 729

  Fly  2403 DESHLSLEFITRKP----DGLIIYN------------GPI----------VPPERDETLISDFIA 2441
            .|...:..|::.|.    ..:||.|            ||:          ......|.....|.|
  Rat   730 QEIASNTGFLSSKDHLPVTQIIITNSNRTNSEAAWRIGPLRCYGDRHFWNAVSFSTEASYLHFSA 794

  Fly  2442 LELE------------------------RGYPRL----------LIDFGSGTLELRVKTKKTLDD 2472
            ..:|                        :|:.||          .||.|:..:||.|::...|:|
  Rat   795 FHVEFSADISFFFKTTALSGIFLENLGIKGFLRLEMSSPSEVIFAIDVGNSPIELLVQSPYPLND 859

  Fly  2473 GEWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVG 2537
            .:||.|....:.:...:.|            |..|....::|.|:       |..|.:::.|.:|
  Rat   860 NQWHYIQAERNIKETLLQV------------DNLPKNKREVSDQS-------NFLLQLSSQLFIG 905

  Fly  2538 GLYREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAH-----PGLSRNSVAGCPQTEEVCA 2597
            |....|              |||.||||:|..|.:..||..     ||:.    .|||      .
  Rat   906 GTSSRQ--------------KGFLGCIRSLHLNGQKIDLEERAKITPGVR----PGCP------G 946

  Fly  2598 QTETTAR-CWEHGNCVGSLSEARCHC-RPGWTGPACNIPTIPTTFKAQSYVKYALSFEP------ 2654
            ...:..| |...|.||...:...|.| ...:.||.|. ..:...|.:.:.|.|... ||
  Rat   947 HCSSYGRNCHNGGKCVEKHNGYSCDCTNSPFEGPFCQ-KEMSALFYSGTSVTYMFQ-EPYPVAKN 1009

  Fly  2655 ----------DRFSTQ--VQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSLRTE 2707
                      |...::  |.|.|.|.:....|..:.........||..::|.|...|.|:  :.|
  Rat  1010 TSLSSSAIYKDTAPSKEIVTLSFITAQAPALLLYLKFSPQSFLAILLSRNGSLQIHYQLS--KVE 1072

  Fly  2708 EKDLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVYAGGK 2772
            .....:.:..:.:.:.|.|.:||.|...::::|       .:.|.:              ....:
  Rat  1073 SHVFTVGSENLANRRVHEVNMNRNGQELSIQVD-------QQLFSY--------------NFSPE 1116

  Fly  2773 AEYTGVRTFEVYADYQKSCLDDIRLEGK---HLPLPPAMNGTQWGQATMARNLE-KGCPSNKPCS 2833
            .|:..||:.               :.||   .|.|.|        :.|.|..|. .||.|:.. .
  Rat  1117 VEFQTVRSL---------------ILGKVTETLVLNP--------EVTQANTLGFVGCLSSVQ-Y 1157

  Fly  2834 NVICPDPFECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDM--PCMNGATCINLEPRLRYRCI 2896
            |.|.|           .:.......|.....:|.:..:.|..|  ...||.|.:       |...
  Rat  1158 NHIAP-----------LKAALRHASIAPVTVQGTLTESSCGSMVESYANGVTTV-------YSSS 1204

  Fly  2897 CPDGFWGENCELVQEGQTLKLSMGALAAILVCLLIILILVLVFVVYNRRREAHIKYPGPDDDVRE 2961
            .|.|...|:..|....|:....:|.:.||:..:...:|.::...:| :.:::|...|..:.:..|
  Rat  1205 DPFGNTDEHEPLTNAIQSDSAFIGGVIAIVTFIAFGVIGIMTHFLY-QHKQSHHTNPMKEKEYPE 1268

  Fly  2962 NI 2963
            |:
  Rat  1269 NL 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637	16/75 (21%)
		EGF	2350..2380	CDD:278437	12/30 (40%)
		LamG	2385..2570	CDD:238058	52/364 (14%)
		EGF_2	<2605..2631	CDD:285248	8/26 (31%)
		Laminin_G_2	2665..2800	CDD:280389	20/134 (15%)
		EGF_CA	2869..2907	CDD:238011	9/39 (23%)
		Cadherin_C	2952..3088	CDD:279398	3/12 (25%)
LOC304725	NP_001316828.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910