Protein Alignment CadN and cdh2

DIOPT Version :10

• Sequence 1: NP_001027277.1
• Gene: CadN / 35070
• FlyBaseID: FBgn0015609
• Length: 3101
• Species: Drosophila melanogaster
• Sequence 2: NP_571156.2
• Gene: cdh2 / 30291
• ZFINID: ZDB-GENE-990415-171
• Length: 893
• Species: Danio rerio
• Alignment Length: 1739
• Identity: 314/1739 - (18%)
• Similarity: 463/1739 - (26%)
• Gaps: 944/1739 - (54%)

  Fly  1416 PYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGAIYVAGALD 1480
            |.|.::.|.....:.......:|.|...|....|.:|:|  ||: ...|.: :..|.:..|..|.
Zfish    29 PGFTENEYNVMTADVITEGQVLLKVDFVDCGRGSGLRFE--SGD-PADFRI-DADGTVMAARTLQ 89

  Fly  1481 YETRRRYELRLAASD-NLKENYTTVIIHV-----KDVNDNPPVFERPTYRTQITEEDDRNLPKR- 1538
            ...|:...|.:.|.| |.:|.:   ::|:     |.|    ||...|.:...:..:|..|..||
Zfish    90 LTDRKGQSLEIKAKDENSQEQW---MVHINFTQPKQV----PVILFPRHSVLVKGDDSVNRVKRD 147

  Fly  1539 -------VL---------QVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLK 1587
                   ||         ::.....|||:...:.|.:||.|.| .|| ...|.|:..:|.:.|.|
Zfish   148 WVIPPVNVLENSRKQFPEELVKIQSDKDKSNTLRYSVTGPGAD-QNP-TGLFIIDPISGLLSVTK 210

  Fly  1588 PLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMV 1652
            ||||:.   .|.:.....|.|..|..:....|:.:|:.|:|||.|.|...::.|.|.|....|..
Zfish   211 PLDREH---IPNFHLRAHAVDINGNQMENPIDIIINVIDMNDNRPEFTHQIWNGTVDEGAKPGTF 272

  Fly  1653 VMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYS-- 1715
            |||:|:.|.||||. :|..|.|.|.... .|...|.:|.|...||.|.|....||||:.|.|:
Zfish   273 VMTVTSQDKDDPNT-ANGMLRYKILSQT-PESPSSNMFTINNKTGKIITVAAGLDREKVPQYTLI 335

  Fly  1716 IQVVAMDGG---GLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDED 1777
            ||...|:|.   ||..|.||.||:.|:||..|:||::.:..||.|.....:  :..||||..||.
Zfish   336 IQATDMEGNPTYGLSNTATAVIRLLDVNDNAPEFTRETFHGEVPENRVNVI--VTNLTVTDKDEP 398

  Fly  1778 ETNKFQ--YKVIDNSGYGADKFTM----VRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKG 1836
            .|..:.  |::|  ||....:|::    |.|.   |.:.:|:|:|:|   .:..|...:..
Zfish   399 GTPAWNAVYRII--SGDPTGRFSIPTDPVTNE---GLVTVVKPVDFE---MNRSFMLTVVA---- 451

  Fly  1837 EDND----NDKYHVAYSWVVVKLR--DINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQG 1895
             ||:    :..:....|...|.:|  |:|:: |:|:....::.:.|.....:.|..|.|.|||:.
Zfish   452 -DNEVPLASGIHRTRQSTATVSIRVIDVNES-PNFDPNPKQIKLEEGLPQWSMLTTFTAHDPDRY 514

  Fly  1896 GKSKVSYS----------IDRSSDRQRQFAINQNGSVTIQRSLDREVVPRHQVKILAIDDGSPPK 1950
            .:..:|||          ||.::.|....|:....|..::.:|       :....:|.|:|.|..
Zfish   515 MQQTISYSKLYDPANWLEIDPNNGRISTIAVLDRESPYVKNNL-------YNATFMASDNGVPRA 572

  Fly  1951 TATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRLDPSAD 2015
            :.|.||.:.:.|||||||:       |.|:..   :|.|                   |.:|:|.
Zfish   573 SGTGTLQIYLLDINDNAPR-------VFPQEA---EVCE-------------------RPEPNAI 608

  Fly  2016 DIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDV 2080
            :|                                                        |.:.||:
Zfish   609 NI--------------------------------------------------------TAVDGDL 617

  Fly  2081 NDNKMQPGSKDIFVYNYQGQSPDTPIGRVYVYDLDDWDLPDKKFYWEAMEHPRFKLDEDSGMVTM 2145
            |.|                ..|       |.:     :||::
Zfish   618 NPN----------------AGP-------YAF-----ELPNR----------------------- 631

  Fly  2146 RAGTREGRYHLRFKVYDRKHTQTDIPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRT 2210
                                 .:||..|.|:|               |:||
Zfish   632 ---------------------PSDIRRNWTLT---------------RISG-------------- 646

  Fly  2211 QSMSRSKMDRFRDKLADLLNTERENVDIFSVQLKRKHPPLTDVRFSAHGSPYYKPVRLNGIVLMH 2275
                                                                             
Zfish   647 ----------------------------------------------------------------- 646

  Fly  2276 REEIEKDVGINITMVGIDECLYENQMCEGSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCG 2340
                                                                             
Zfish   647 ----------------------------------------------------------------- 646

  Fly  2341 ARNFTKPESCRTTPCHNGGRCVDTRFGPHCSCPVGYTGPRCQQTTRSFRGNGWAWYPPLEMCDES 2405
                                                                          |.:
Zfish   647 --------------------------------------------------------------DHA 649

  Fly  2406 HLSLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTL 2470
            .|||:         |.|                     ||           ||..||.:..
Zfish   650 QLSLK---------ISY---------------------LE-----------SGIYELPISI---- 669

  Fly  2471 DDGEWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFN-EYLNVNAPL 2534
                         |:|                                |.:|..| .||.:
Zfish   670 -------------TDS--------------------------------GNLPMSNTTYLRI---- 685

  Fly  2535 QVGGLYREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCAQT 2599
                                                                       :||
Zfish   686 -----------------------------------------------------------KVC--- 688

  Fly  2600 ETTARCWEHGNCVGSLSEARCHCRPGWTGPACNIPTIPTTFKAQSYVKYALSFEPDRFSTQVQLR 2664
                :|..||:||
Zfish   689 ----QCDHHGDCV---------------------------------------------------- 697

  Fly  2665 FRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVVKVN 2729
                                                                             
Zfish   698 ----------------------------------------------------------------- 697

  Fly  2730 RYGSAATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKSCLDD 2794
                                             ..|.:.|.|
Zfish   698 ---------------------------------DMERIMAAG----------------------- 706

  Fly  2795 IRLEGKHLPLPPAMNGTQWGQATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRI 2859
                                                                             
Zfish   707 ----------------------------------------------------------------- 706

  Fly  2860 MSPDSKGCMDRNECLDMPCMNGATCINLEPRLRYRCICPDGFWGENCELVQEGQTLKLSMGALAA 2924
                                                                     |..||:.|
Zfish   707 ---------------------------------------------------------LGTGAIIA 714

  Fly  2925 ILVCLLIILILVLVFVVYNRR----REAHIKYPGPDDDVRENIINYDDEGGGEDDMTAFDITPLQ 2985
            ||:|::|:|:|||:||::.:|    |:|......|:||||:||:.||:|||||:|.. :|::.||
Zfish   715 ILICIIILLVLVLMFVMWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQD-YDLSQLQ 778

  Fly  2986 IPIGGPMPPEL-----------APMKMPIMYPVMTLMPGQEPNVGMFIEEHKKRADGDPNAPPFD 3039
            .|  ..:.|::           .||.....||:.:..| ...::|.||.|..|.||.||.|||:|
Zfish   779 QP--DTLEPDMIKPVGIRRLDERPMHSEPNYPIRSAAP-HPGDIGEFIHEGLKAADTDPTAPPYD 840

  Fly  3040 DLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGPRFDKLANMYG 3088
            .|..:.|||.||||||||||.|.:....|:||||..|||||.|||:|||
Zfish   841 SLLVFDYEGSGSTAGSLSSLHSSSSGGDQDYDYLNDWGPRFRKLADMYG 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		CA_like	449..541	CDD:481204
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637	22/96 (23%)
		Cadherin_repeat	1522..1630	CDD:206637	33/124 (27%)
		Cadherin_repeat	1638..1741	CDD:206637	43/107 (40%)
		CA	1770..1863	CDD:214520	26/104 (25%)
		Cadherin_repeat	1871..1966	CDD:206637	26/104 (25%)
		Cadherin_repeat	1974..2083	CDD:206637	12/108 (11%)
		EGF	2350..2380	CDD:394967	0/29 (0%)
		LamG	2385..2570	CDD:238058	19/185 (10%)
		EGF_2	2605..2631	CDD:400365	5/25 (20%)
		LamG	2637..2797	CDD:238058	3/159 (2%)
		EGF_CA	2869..2907	CDD:238011	0/37 (0%)
		CADH_Y-type_LIR	3029..3088	CDD:460041	37/58 (64%)
cdh2	NP_571156.2	Cadherin_pro	27..117	CDD:214999	22/94 (23%)
		CA_like	150..250	CDD:481204	29/104 (28%)
		Cadherin_repeat	260..365	CDD:206637	44/106 (42%)
		Cadherin_repeat	373..480	CDD:206637	29/121 (24%)
		Cadherin_repeat	490..588	CDD:206637	26/104 (25%)
		Cadherin	595..688	CDD:394985	42/616 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..815		9/40 (23%)
		CADH_Y-type_LIR	830..889	CDD:460041	37/58 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	851..872		12/20 (60%)