DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and Notch2

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_077334.2	Gene:	Notch2 / 29492	RGDID:	3188	Length:	2471	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	157/745 - (21%)
Similarity:	214/745 - (28%)	Gaps:	304/745 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  2292 IDECLYEN-QMCE--GSCTNS------------------LEISPL---PYMVNANKTALVGVRVD 2332
            :|||...| ..||  |.|.|:                  ::|:..   |...:|  |.|     |
  Rat   416 VDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDA--TCL-----D 473

  Fly  2333 TIADCTC-------GARNFTKPESCRTTPCHNGGRCVD--TRFGPHCSCPVGYTGPRCQ------ 2382
            .|...||       |.....:...|::.||.|.|:|||  .||  .|.||.|:|||.||
  Rat   474 KIGGFTCLCMPGFKGVHCELEVNECQSNPCVNNGQCVDKVNRF--QCLCPPGFTGPVCQIDIDDC 536

  Fly  2383 --------------------QTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKP-------DGLI 2420
                                |....|.|.         :|||   :::.....|       ||:.
  Rat   537 SSTPCLNGAKCIDHPNGYECQCATGFTGT---------LCDE---NIDNCDPDPCHHGQCQDGID 589

  Fly  2421 IYN--------GPIVPPERDE----TLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDG 2473
            .|.        |.|...:.||    ..::|...::|..||.   .:...||..|
  Rat   590 SYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQ---CNCQPGTSGL----------- 640

  Fly  2474 EWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMS---CQARGQIPPFNEYLNVNAPLQ 2535
                                  :.||         .|||.:   |.....:...|.|..|.:|..
  Rat   641 ----------------------NCEI---------NFDDCASNPCLHGACVDGINRYSCVCSPGF 674

  Fly  2536 VGGLYREQFDQSLYFWHYMPTAKGFDGCIRNL----------VHNSKLYDLAHPGLSRNSVAGCP 2590
            .|.......|:..    ..|..||.. ||.::          .|:...|...:..||...:
  Rat   675 TGQRCNIDIDECA----SNPCRKGAT-CINDVNGFRCMCPEGPHHPSCYSQVNECLSSPCI---- 730

  Fly  2591 QTEEVCAQTETTARCWEHGNCVGSLSEARCHCRPGWTGPACNIP--------------------- 2634
                             ||||.|.||..:|.|..||.|..|.:.
  Rat   731 -----------------HGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCNNLVNG 778

  Fly  2635 ---TIPTTFKAQSYVKYALSFEPDRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDG--- 2693
               |....||.     |......|..::...|...|                   .|:...|
  Rat   779 YRCTCKKGFKG-----YNCQVNIDECASNPCLNQGT-------------------CLDDVSGYTC 819

  Fly  2694 HLHFRYNLNSLRTE----EKDLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEGRRYNETFEFV 2754
            |....|...:.:|.    ..:...||.|..:..       .:.|...|...|.:|:|
  Rat   820 HCMLPYTGKNCQTVLAPCSPNPCENAAVCKEAP-------NFESFTCLCAPGWQGQR-------- 869

  Fly  2755 GHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKSCLDD---IRLEGKHL-PLPPAMNGTQWGQ 2815
                ..||..|.|                    .|.|:::   ...:|.:: ..||..:|....:
  Rat   870 ----CTVDVDECV--------------------SKPCMNNGICHNTQGSYMCECPPGFSGMDCEE 910

  Fly  2816 ATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPCMN 2880
            ..      ..|.:| ||.|     ...|||..|.:.|.|..|.:   ..|...|.||||..||.|
  Rat   911 DI------NDCLAN-PCQN-----GGSCVDKVNTFSCLCLPGFV---GDKCQTDMNECLSEPCKN 960

  Fly  2881 GATC---INLEPRLRYRCICPDGFWGENCE 2907
            |.||   :|     .|.|.||.||.|.:||
  Rat   961 GGTCSDYVN-----SYTCTCPAGFHGVHCE 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	16/31 (52%)
		LamG	2385..2570	CDD:238058	37/216 (17%)
		EGF_2	<2605..2631	CDD:285248	12/25 (48%)
		Laminin_G_2	2665..2800	CDD:280389	20/144 (14%)
		EGF_CA	2869..2907	CDD:238011	19/40 (48%)
		Cadherin_C	2952..3088	CDD:279398
Notch2	NP_077334.2	EGF_CA	109..143	CDD:238011
		EGF_CA	182..218	CDD:238011
		EGF_CA	260..296	CDD:238011
		EGF_CA	298..335	CDD:238011
		EGF_CA	415..454	CDD:238011	9/37 (24%)
		EGF_CA	456..492	CDD:238011	10/42 (24%)
		EGF_CA	495..530	CDD:238011	17/36 (47%)
		EGF_CA	532..567	CDD:238011	3/43 (7%)
		EGF_CA	570..604	CDD:238011	5/33 (15%)
		EGF_CA	608..643	CDD:238011	9/70 (13%)
		EGF_CA	645..679	CDD:238011	9/33 (27%)
		EGF_CA	682..717	CDD:238011	7/39 (18%)
		EGF_CA	757..793	CDD:238011	4/40 (10%)
		EGF_CA	795..831	CDD:238011	7/54 (13%)
		EGF_CA	873..909	CDD:238011	9/55 (16%)
		EGF_CA	911..947	CDD:238011	13/50 (26%)
		EGF_CA	949..985	CDD:238011	19/40 (48%)
		EGF_CA	987..1022	CDD:238011
		EGF_CA	1025..1061	CDD:238011
		EGF_CA	1117..1147	CDD:238011
		EGF_CA	1151..1185	CDD:238011
		EGF_CA	1188..1223	CDD:238011
		EGF_CA	1225..1262	CDD:238011
		EGF_CA	1264..1302	CDD:238011
		EGF_CA	<1312..1343	CDD:238011
		Notch	1423..1456	CDD:278494
		Negative regulatory region (NRR). /evidence=ECO:0000250	1425..1677
		Notch	1463..1497	CDD:278494
		Notch	1501..1534	CDD:278494
		NOD	1540..1591	CDD:284282
		NODP	1619..1673	CDD:284987
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1751..1788
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1794..1813
		Ank_2	<1820..1907	CDD:289560
		ANK repeat	1827..1874	CDD:293786
		ANK 1	1827..1871
		ANK	1872..1997	CDD:238125
		ANK 2	1876..1905
		ANK repeat	1877..1907	CDD:293786
		Ank_2	1881..1974	CDD:289560
		ANK 3	1909..1939
		ANK	1938..2062	CDD:238125
		ANK repeat	1943..1974	CDD:293786
		ANK 4	1943..1972
		Ank_2	1948..2040	CDD:289560
		ANK repeat	1976..2007	CDD:293786
		ANK 5	1976..2005
		ANK repeat	2009..2040	CDD:293786
		ANK 6	2009..2038
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2097..2116
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2380..2471
		DUF3454	2381..2439	CDD:288764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910