DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Cdh22

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_062034.2	Gene:	Cdh22 / 29182	RGDID:	2321	Length:	813	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	180/596 - (30%)
Similarity:	280/596 - (46%)	Gaps:	80/596 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1521 PTYRTQITEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFV 1585
            |.|..:|..:.|             :||    ..|.|.::|:|      |.:.|.|:..||:|..
  Rat    77 PLYVGKIHSDSD-------------EGD----GTIKYTISGEG------AGTIFLIDELTGDIHA 118

  Fly  1586 LKPLDRDQPNGRPQWRFTVFAQDEGGEGLV-GYADVQVNLKDINDNAPIFPQGVYFGNVTENGTA 1649
            .:.|||:|   :..:.....|:|.....|: ..::..:.::||||:.|.|..|.|.|:|.|....
  Rat   119 TERLDREQ---KTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPT 180

  Fly  1650 GMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDY 1714
            |..||.:.|.|.|||..||:||||||:       ..|...|.::|.||||:|||..||||....|
  Rat   181 GTSVMQVMASDADDPTYGSSARLVYSV-------LDGEHHFTVDPKTGVIRTAVPDLDRESQERY 238

  Fly  1715 SIQVVAMDG----GGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETD--GTALPEMPILTVTV 1773
            .:.:.|.|.    |||.|:.|.:|.|.|:||.||:|.:..:...:.|:.  |||:..     |..
  Rat   239 EVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGR-----VKA 298

  Fly  1774 HDED--ETNKFQYKVIDNSGYGADKFTMVRNNDGTGSLKIVQP-LDYEDQ------LQS-NGF-- 1826
            .|.|  |.....|.:.:.||.|.|.|.:..::|...::.:||. ||:|.|      |:: |.|
  Rat   299 EDSDVGENTDMTYHLREESGSGGDAFKVTTDSDTQEAIIVVQKHLDFESQQVHTVVLEALNKFVD 363

  Fly  1827 -RFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKAT 1890
             ||.    |.|...|.....||.:.|        |..|.|...:..:.|.||.:||:.:....|.
  Rat   364 PRFA----DLGTFRDQAIVRVAVTDV--------DEPPEFRPPSGLLEVQEDAQVGSLVGVVTAR 416

  Fly  1891 DPDQGGKSKVSYSIDRSSDRQRQFAIN-QNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATA 1954
            |||...: .|.|:|||.||.::.|.|: ..|::...:.||||....|.:.:||::..:..:.:.|
  Rat   417 DPDAANR-PVRYAIDRDSDLEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRA 480

  Fly  1955 TLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIR 2019
            :|.:.:.|:|||.|:....|...:.|...|.::::.::..|.|..: .|..|.|||.|.......
  Rat   481 SLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQ-GGHRFYFRLVPEEPSNPH 544

  Fly  2020 ASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTV-IIGDVNDN 2083
            .|....:|...      ||.:....|:|::|..:::||::.|.|.|.::.|.|||: |.|..:..
  Rat   545 FSLLDIEDNTA------AVHTQHVGFNRQEQDVFLLPILVVDSGPPTLSSTGTLTIRICGCDSSG 603

  Fly  2084 KMQPGSKDIFV 2094
            .:|..:...||
  Rat   604 TIQSCNTTAFV 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	25/108 (23%)
		Cadherin_repeat	1638..1741	CDD:206637	45/106 (42%)
		Cadherin_repeat	1762..1861	CDD:206637	29/111 (26%)
		Cadherin_repeat	1871..1966	CDD:206637	30/95 (32%)
		Cadherin_repeat	1974..2083	CDD:206637	29/109 (27%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Cdh22	NP_062034.2	Cadherin_repeat	80..160	CDD:206637	23/105 (22%)
		Cadherin_repeat	169..270	CDD:206637	46/107 (43%)
		Cadherin_repeat	279..387	CDD:206637	32/124 (26%)
		Cadherin_repeat	398..492	CDD:206637	30/94 (32%)
		Cadherin_repeat	499..597	CDD:206637	27/104 (26%)
		Cadherin_C	645..804	CDD:395833
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9369
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910