Protein Alignment CadN and Dsg3

DIOPT Version :10

• Sequence 1: NP_001027277.1
• Gene: CadN / 35070
• FlyBaseID: FBgn0015609
• Length: 3101
• Species: Drosophila melanogaster
• Sequence 2: NP_001178008.2
• Gene: Dsg3 / 291752
• RGDID: 1592103
• Length: 1043
• Species: Rattus norvegicus
• Alignment Length: 598
• Identity: 159/598 - (26%)
• Similarity: 273/598 - (45%)
• Gaps: 82/598 - (13%)

  Fly  1529 EEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQ 1593
            |.:|.:....:.::|:   |..:.|.|.|.::|.||  |.|....|.::...|:|.:...:||::
  Rat    60 EREDNSKRNPIAKITS---DFQKNQKITYRISGVGI--DQPPFGIFVVDPNNGDINITAIVDREE 119

  Fly  1594 PNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTA 1658
               .|.:..|..|.:..|:.:.....:.|.:.|:|||||||.|.::.|.:.||..:..:||.:.|
  Rat   120 ---TPSFLITCRALNALGQDVERPLILTVKILDVNDNAPIFSQTIFKGEIEENSASNSLVMILNA 181

  Fly  1659 VDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAM-- 1721
            .|.|:||. .|:::.:.|   |.:|..|..:|.|..:||.::|....||||:...|.:.|...
  Rat   182 TDADEPNH-MNSKIAFKI---VSQEPAGMSMFLISRNTGEVRTLTSSLDREQVGSYHLIVSGADN 242

  Fly  1722 DGGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKV 1786
            ||.||......||::||:||..|..|..::...::|  .|...|:....||..||:.|:.:....
  Rat   243 DGTGLSTQCECSIKIKDVNDNFPVLTDSQYSARIEE--NTLNSELLRFQVTDWDEEYTDNWLAVY 305

  Fly  1787 IDNSGYGADKF---TMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDN--DKYHV 1846
            ...||...:.|   |..|.|:|.  ||:|:.|||| |:||  .:|.|.|.:|.|.:.:  .:|.|
  Rat   306 FFTSGNEGNWFEIETDPRTNEGI--LKLVKVLDYE-QMQS--MQFSIAVRNKAEFHQSVISQYQV 365

  Fly  1847 AYSWVVVKLRDINDN---KPHFERANVEVSVFEDTKVGTELEKFKATDPDQG-GKSKVSYSIDR- 1906
            ..:.|.:::.::.:.   :|......|:..|..:...|..|..::|||.|.| ..|.|.|.:.|
  Rat   366 QSTPVTIQVINVQEGISFRPPSRTFTVQRGVSINKLAGYILGTYQATDEDTGKAASSVRYVLGRN 430

  Fly  1907 --------SSDRQRQFA--INQNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQ 1961
                    |...:.:|.  ||::.:..:.:::..||        ||||:.: .||:|.|:.|.|.
  Rat   431 DGGFLVIDSKTAEIKFVKNINRDSTFIVNKTISAEV--------LAIDENT-GKTSTGTVYVEVP 486

  Fly  1962 DINDNAPKFLKDYRPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQ 2026
            ..|:|.|..:.:.|.:..........|..|     ||:|..||                 :.|..
  Rat   487 SFNENCPSVVLEKREICTSSPSVTLSVRTL-----DRAKYTGP-----------------YTVSL 529

  Fly  2027 DQKGANGDGMAVISSLRSFDREQQKE-------YMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNK 2084
            :::......:..|::|.:.....|.:       |.:|:::||:.........:||:.:...:|..
  Rat   530 EEQPLKLPVVWTITTLNATSALLQAQQHISPGVYNVPVIVKDNQDGQCDTLESLTLTVCQCDDRS 594

  Fly  2085 M--QPG-SKDIFV 2094
            |  .|| |::.|:
  Rat   595 MCRAPGPSREPFI 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		CA_like	449..541	CDD:481204
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	24/100 (24%)
		Cadherin_repeat	1638..1741	CDD:206637	34/104 (33%)
		CA	1770..1863	CDD:214520	30/100 (30%)
		Cadherin_repeat	1871..1966	CDD:206637	29/106 (27%)
		Cadherin_repeat	1974..2083	CDD:206637	18/115 (16%)
		EGF	2350..2380	CDD:394967
		LamG	2385..2570	CDD:238058
		EGF_2	2605..2631	CDD:400365
		LamG	2637..2797	CDD:238058
		EGF_CA	2869..2907	CDD:238011
		CADH_Y-type_LIR	3029..3088	CDD:460041
Dsg3	NP_001178008.2	CA	75..155	CDD:214520	23/87 (26%)
		Cadherin_repeat	161..263	CDD:206637	35/105 (33%)
		Cadherin	272..375	CDD:394985	33/109 (30%)
		Cadherin_repeat	396..491	CDD:206637	29/103 (28%)