DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and Cdh7

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001012755.1	Gene:	Cdh7 / 29162	RGDID:	1306856	Length:	785	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	185/598 - (30%)
Similarity:	294/598 - (49%)	Gaps:	83/598 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1516 PVFERPTYRTQ---------ITEEDDRNLPKRVLQVTATDGDKDRPQNIV-YFLTGQGIDPDNPA 1570
            |.|:....||:         :.||...:.|   |.|.....|.|:....: |.|:|:|      |
  Rat    36 PYFQLGRSRTKRSWVWNQFFVLEEYMGSDP---LYVGKLHSDVDKGDGFIKYILSGEG------A 91

  Fly  1571 NSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQ--DE-GGEGLVGYADVQVNLKDINDNAP 1632
            :|.|.|:..||:|...|.|||::     |..:|:.||  |. ..:.:...::..:.::|||||.|
  Rat    92 SSIFIIDENTGDIHATKRLDREE-----QAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEP 151

  Fly  1633 IFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTG 1697
            .|..|.|...|.|....|..|:.:||.|.|||..|::||:||||.:       |.|.|.:||.||
  Rat   152 KFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQ-------GQPYFSVEPKTG 209

  Fly  1698 VIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDET 1758
            |||||:..:|||....|.:.:.|.|    .|||.||.:.::.:.|:||.||:|.:..:     :.
  Rat   210 VIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSY-----QY 269

  Fly  1759 DGTALPE-MPILTVTVH------DEDETNKFQYKVIDNSGYGADKFTMVRNNDGTGSLKIVQPLD 1816
            :|   || :|:.:|...      |.....:.:||::|..|.|..|.:..::.. .|.:.|.:.||
  Rat   270 NG---PESLPVASVVARIKAADADIGVNAEMEYKIVDGDGLGIFKISPDKDTQ-EGIITIQKELD 330

  Fly  1817 YEDQLQSNGFRFRIQVNDKGED---------NDNDKYHVAYSWVVVKLRDINDNKPHFERANVEV 1872
            :|   ....:..||:..::..|         :|.       :.|.:.:.|: |..|.|......:
  Rat   331 FE---AKTSYTLRIEAANRDADPRFLSLGPFSDT-------TTVKIIVEDV-DEPPVFSSPLYPM 384

  Fly  1873 SVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQN-GSVTIQRSLDREVVPRH 1936
            .|.|.|:||..:....|.||| ...|.|.|||||::|.:|.|.|:.| |.:|..:|||||..|.|
  Rat   385 EVSEATQVGHIIGTVAAHDPD-SSNSPVRYSIDRNTDLERYFNIDANSGIITTAKSLDRETNPVH 448

  Fly  1937 QVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEILATDDDDRSKS 2001
            .:.:||::..:|.:.....:.:.:.|||||||:|..||...:.|:..|.:|::.::..|.| ..|
  Rat   449 NITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAIDKD-EPS 512

  Fly  2002 NGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKDHGSPA 2066
            ||..|.|.|.....:.:.:|.|..:|...      ::::....|.|::|..|.:||.|.|:|||:
  Rat   513 NGHQFYFSLTTDMANNLNSSLKDNKDNTA------SILTRRNGFRRQEQSVYYLPIFIVDNGSPS 571

  Fly  2067 MTGTSTLTVIIGD 2079
            ::.|:|||:.:.|
  Rat   572 LSSTNTLTIRVCD 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	32/120 (27%)
		Cadherin_repeat	1638..1741	CDD:206637	42/106 (40%)
		Cadherin_repeat	1762..1861	CDD:206637	22/114 (19%)
		Cadherin_repeat	1871..1966	CDD:206637	36/95 (38%)
		Cadherin_repeat	1974..2083	CDD:206637	31/106 (29%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Cdh7	NP_001012755.1	CA	73..151	CDD:214520	27/88 (31%)
		Cadherin_repeat	157..258	CDD:206637	43/107 (40%)
		Cadherin_repeat	266..373	CDD:206637	23/126 (18%)
		Cadherin_repeat	382..478	CDD:206637	36/96 (38%)
		Cadherin_repeat	486..584	CDD:206637	30/104 (29%)
		Cadherin_C	639..777	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5067
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910