DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and CNTNAP2

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_054860.1	Gene:	CNTNAP2 / 26047	HGNCID:	13830	Length:	1331	Species:	Homo sapiens

Alignment Length:	765	Identity:	164/765 - (21%)
Similarity:	263/765 - (34%)	Gaps:	228/765 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  2178 VREIPHEAVVNSGSVRLSGISDEDFIRVWNYR--TQSMSRSKMDRFRDKLADLLNTERENVDIFS 2240
            |..:||.|..:|.|:  ||.....:.:: |.|  ....|.|..|.::....|..|  |:.:...:
Human    40 VSGLPHVAFSSSSSI--SGSYSPGYAKI-NKRGGAGGWSPSDSDHYQWLQVDFGN--RKQISAIA 99

  Fly  2241 VQLKRKHPP-LTDVR--FSAHG---SPYYK-------PVRLN--GIVLMHREEIEKDVGINITMV 2290
            .|.:..... :|..|  :|..|   .||::       |..:|  |:|   |.|::..:
Human   100 TQGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVV---RHELQHPI------- 154

  Fly  2291 GIDECLYENQMCEGSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNFTKPESCRTTPC 2355
                           ....:.|.||.:    |....:|:|:: :..|:..|
Human   155 ---------------IARYVRIVPLDW----NGEGRIGLRIE-VYGCSYWA-------------- 185

  Fly  2356 HNGGRCVDT-RFGPHCSCPVGYTGPRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGL 2419
                   |. .|..|...|..:...: .:|.:..                  ::|.|.|.:.:|:
Human   186 -------DVINFDGHVVLPYRFRNKK-MKTLKDV------------------IALNFKTSESEGV 224

  Fly  2420 IIYNGPIVPPERDETLISDFIALELERGYPRLLIDFGSGTL-----ELRVKTKKTLDDGEWHRID 2479
            |::.         |....|:|.|||::....|.::.||..|     ...|.|...|||..||.:.
Human   225 ILHG---------EGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVV 280

  Fly  2480 LFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGLYREQF 2544
            :.....||.:.:|  :|.:    ...|..|||               ||:::..:..||:.....
Human   281 IERQGRSINLTLD--RSMQ----HFRTNGEFD---------------YLDLDYEITFGGIPFSGK 324

  Fly  2545 DQSLYFWHYMPTAKGFDGCIRNLVHNS-KLYDLAHPGLSRNSVAGCPQTEEVCAQTETTARCWEH 2608
            ..|       .:.|.|.||:.::.:|. .:.|||.    |..:                    |.
Human   325 PSS-------SSRKNFKGCMESINYNGVNITDLAR----RKKL--------------------EP 358

  Fly  2609 GNCVGSLSEARCHCRPGWTGPACNIP-TIPTTFKAQSYVKYALSFEPDRFSTQVQLRFRTREEYG 2672
            .| ||:||.            :|..| |:|..|.|.||::.......|.||  |..:|||....|
Human   359 SN-VGNLSF------------SCVEPYTVPVFFNATSYLEVPGRLNQDLFS--VSFQFRTWNPNG 408

  Fly  2673 ELF--RVSDQ-HNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVVKVNRYGSA 2734
            .|.  ..:|. .|.|..:.|.|.| :|.  |:...:..:.|: .:...:||||||.|:.....:.
Human   409 LLVFSHFADNLGNVEIDLTESKVG-VHI--NITQTKMSQIDI-SSGSGLNDGQWHEVRFLAKENF 469

  Fly  2735 ATLELDGGEGR--RYNETFEFVGHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKSCLDDIRL 2797
            |.|.:||.|..  |.|..        |.|...|..:.||........:..|.....:.|:..|::
Human   470 AILTIDGDEASAVRTNSP--------LQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQV 526

  Fly  2798 EGKHLPLPPAMNGTQWGQATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRIMSP 2862
            :.:.:.|...........|.::.::   |.....|....|....:|...|:.::|||
Human   527 DDQLVNLYEVAQRKPGSFANVSIDM---CAIIDRCVPNHCEHGGKCSQTWDSFKCTC-------- 580

  Fly  2863 DSKGCMDRNECLDMPCMNGATCIN--LEPRL----------RYRCICPDG 2900
            |..|            .:||||.|  .||..          .|..|.|||
Human   581 DETG------------YSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDG 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	4/30 (13%)
		LamG	2385..2570	CDD:238058	39/189 (21%)
		EGF_2	<2605..2631	CDD:285248	6/25 (24%)
		Laminin_G_2	2665..2800	CDD:280389	36/139 (26%)
		EGF_CA	2869..2907	CDD:238011	12/44 (27%)
		Cadherin_C	2952..3088	CDD:279398
CNTNAP2	NP_054860.1	FA58C	34..181	CDD:214572	35/175 (20%)
		FA58C	<70..180	CDD:238014	25/141 (18%)
		Laminin_G_2	216..345	CDD:280389	39/165 (24%)
		Laminin_G_2	401..529	CDD:280389	36/139 (26%)
		EGF_CA	555..590	CDD:238011	11/54 (20%)
		COLFI	609..>632	CDD:295304	5/10 (50%)
		LamG	800..943	CDD:238058
		LamG	1050..1185	CDD:214598
		4.1m	1282..1300	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910