DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Mep1a

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_037275.1	Gene:	Mep1a / 25684	RGDID:	3080	Length:	748	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	131/640 - (20%)
Similarity:	212/640 - (33%)	Gaps:	215/640 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  2420 IIYNGPIVPPERDETL------ISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRI 2478
            :::.||. ...::||:      |.:|.|:..:|      :||.:..|.               |:
  Rat   212 LMHYGPF-SFNKNETIPTITTKIPEFNAIIGQR------LDFSATDLT---------------RL 254

  Fly  2479 DLFWDTESIRMVVDFC--KSAEIAEMEDGTPPEFD----DMS------------CQARGQIPPFN 2525
            :..::......::|.|  :...|..|..||..:.|    |.|            |:|.|....||
  Rat   255 NRMYNCTRTHTLLDHCAFEKTNICGMIQGTRDDADWVHEDSSQPGQVDHTLVGRCKAAGYFMYFN 319

  Fly  2526 EYLNVN---APLQVGGLYREQFDQSLYFWHYMPTAKGFD------------GCIRNLV------- 2568
            ....|.   |.|:...||.::..|.|.|::.| |....|            |.:|.|.
  Rat   320 TSSGVTGEVALLESRILYPKRKQQCLQFFYKM-TGSPSDRLLIWVRRDDNTGNVRQLAKIQTFQG 383

  Fly  2569 ---HNSKLYDLAHPGLSR--------NSVAGCPQTEEVCAQTETTARCWEHGNCVG-------SL 2615
               ||.|   :||..|:.        ....|.|                  ||..|       :|
  Rat   384 DSDHNWK---IAHVTLNEEKKFRYVFQGTKGDP------------------GNSDGGIYLDDITL 427

  Fly  2616 SEARCHCRPGWTGPACNIPTIPTTFKAQSYVKYALSFEPDRFSTQVQLRFRTREEYGELFRVSDQ 2680
            :|..|             ||...|.:..|.| ...:.:.||.   |..||...|.||  |.|:..
  Rat   428 TETPC-------------PTGVWTIRNISQV-LENTVKGDRL---VSPRFYNSEGYG--FGVTLY 473

  Fly  2681 HNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVV-----------------KV 2728
            .|   |.:....|:|...::|.|   .:.|:.|...|.|:.....:                 ..
  Rat   474 PN---GRITSNSGYLGLAFHLYS---GDNDVILEWPVENEQAIMTILDQEPDARNRMSLSLMFTT 532

  Fly  2729 NRYGSAATL-----------------------ELDGGEGRRYNETFEFVGHQWL-----LVDKQE 2765
            ::|.:::.:                       .:|.|.|       :.:.||.|     |.|...
  Rat   533 SKYQTSSAINGSVIWDRPTKVGVYDKDCDCFRSIDWGWG-------QAISHQMLMRRNFLKDDTL 590

  Fly  2766 GVYAGGKAEYTGVRTFEVYADYQKSCLDDIRLEGKHLPLPPAMNGTQWGQATMARNLEKGCPSNK 2830
            .::...| :.|.:|..||....:......:.|:|:. ||....:.....:.::.|.|::..|| :
  Rat   591 IIFVDFK-DLTHLRQTEVPISSRSVIPRGLLLQGQE-PLALGDSRIAMMEESLPRRLDQRQPS-R 652

  Fly  2831 PCSNVICPDPFECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPCMNGATCINLEPRLRYRC 2895
            |..:|....|.|..: |..|                  .|:.|...||.|..||:|::.....||
  Rat   653 PKRSVENTGPMEDHN-WPQY------------------FRDPCDPNPCQNEGTCVNVKGMASCRC 698

  Fly  2896 ICPDGFW--GENCELVQ-EGQTLKLSMGALAAILVCLLIILILVLVFVVYNRRRE 2947
            :....|:  ||.|:.:. .|..|.|.:|.:.|     ||.|..:.....|.:.|:
  Rat   699 VSGHAFFYTGERCQAMHVHGSLLGLLIGCITA-----LIFLTFITFSNTYQKLRQ 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058	40/198 (20%)
		EGF_2	<2605..2631	CDD:285248	6/32 (19%)
		Laminin_G_2	2665..2800	CDD:280389	31/179 (17%)
		EGF_CA	2869..2907	CDD:238011	13/39 (33%)
		Cadherin_C	2952..3088	CDD:279398
Mep1a	NP_037275.1	ZnMc	32..260	CDD:294052	12/69 (17%)
		Astacin	75..261	CDD:279708	12/70 (17%)
		MAM	270..433	CDD:279023	41/197 (21%)
		MAM	270..432	CDD:99706	40/183 (22%)
		MATH	432..596	CDD:295307	35/195 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	641..668		8/28 (29%)
		EGF	676..710	CDD:278437	11/33 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910