DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and Agrn

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_017448655.1	Gene:	Agrn / 25592	RGDID:	2067	Length:	2066	Species:	Rattus norvegicus

Alignment Length:	850	Identity:	180/850 - (21%)
Similarity:	299/850 - (35%)	Gaps:	230/850 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  2190 GSVRLSGISDEDFIRVWNYRTQSMSRSKMDRF-------RDKLADLLNTERENVDIFSVQLKRKH 2247
            |.:.|.|:..::.     :.|..|:..|.:.|       ...|.||........|.:||:|:...
  Rat  1136 GVLELEGVEGQEL-----FYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSVRLRELG 1195

  Fly  2248 P-----PLTDVRFSAHGSPYYKPVRLNGIVLMHREEIEKDVGINI-------------------- 2287
            |     .:.||.|....:.....|   |..|:.:.::.:...:.:
  Rat  1196 PGKLVRAIVDVHFDPTTAFQASDV---GQALLRQIQVSRPWALAVRRPLQEHVRFLDFDWFPTFF 1257

  Fly  2288 --TMVGIDECLYENQMCEGSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNFTKP--- 2347
              ...|....:...:....|...:..::|..|..:.::.........|.......|.|..:|
  Rat  1258 TGAATGTTAAMATARATTVSRLPASSVTPRVYPSHTSRPVGRTTAPPTTRRPPTTATNMDRPRTP 1322

  Fly  2348 ------ESCRTTPCHNGGRCVDTRFGP--HCSCPVGYTGPRCQQ----TTRSFRGNGWAWYPPLE 2400
                  :||.:.||.:||.|.|...|.  .|||..|..|..|::    :..:|:|:.:..:|.|.
  Rat  1323 GHQQPSKSCDSQPCLHGGTCQDQDSGKGFTCSCTAGRGGSVCEKVQPPSMPAFKGHSFLAFPTLR 1387

  Fly  2401 MCDESHLSLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVK 2465
            ......|:|||...:.:||::|||        .....||:||.|..|..:...|.|||...|  .
  Rat  1388 AYHTLRLALEFRALETEGLLLYNG--------NARGKDFLALALLDGRVQFRFDTGSGPAVL--T 1442

  Fly  2466 TKKTLDDGEWHRIDL--FWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYL 2528
            :...::.|.|||::|  .|...::.:              ||..|        ..|:.|...:.|
  Rat  1443 SLVPVEPGRWHRLELSRHWRQGTLSV--------------DGETP--------VVGESPSGTDGL 1485

  Fly  2529 NVNAPLQVGGLYREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLA---------------- 2577
            |::..|.|||:..||....|   .......|..||||.|..|::..:|:
  Rat  1486 NLDTNLYVGGIPEEQVAMVL---DRTSVGVGLKGCIRMLDINNQQLELSDWQRAAVQSSGVGECG 1547

  Fly  2578 -HPGLSRNSVAG--------------CP--QTEEVCAQTETTAR---CWEHGNC-VGSLSEARCH 2621
             ||.|......|              ||  :....||..::..:   |.....| |.|...|:|.
  Rat  1548 DHPCLPNPCHGGALCQALEAGMFLCQCPPGRFGPTCADEKSPCQPNPCHGAAPCRVLSSGGAKCE 1612

  Fly  2622 CRPGWTGPACNIPTIPTT---------FKAQSY--VKYALSFEPDRFSTQ-VQLRFRTREEYGEL 2674
            |..|.:|..|.  |:..|         |...||  :|...:||.|..... :::.|..|...|.|
  Rat  1613 CPLGRSGTFCQ--TVLETAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLARGPSGLL 1675

  Fly  2675 FRVSDQHN--REYGILEIKDGHLHFRYNLNS----LRTEEKDLWLNAIVVNDGQWHVVKVNRYGS 2733
            .....:.:  .::..|.:.:.||.|.|:|..    :|::|.        :..|.|..|.:.|.|.
  Rat  1676 LYNGQKTDGKGDFVSLALHNRHLEFCYDLGKGAAVIRSKEP--------IALGTWVRVFLERNGR 1732

  Fly  2734 AATLEL-DG----GEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKSCLD 2793
            ...|:: ||    ||..:..:    |.|  .:::.:|.:|.||..:::.:......:......:.
  Rat  1733 KGALQVGDGPRVLGESPKSRK----VPH--TMLNLKEPLYIGGAPDFSKLARGAAVSSGFNGVIQ 1791

  Fly  2794 DIRLEGKHLPLPPAMNGTQWGQATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGR 2858
            .:.|.|..|          ..|..:.|.::....::.||:
  Rat  1792 LVSLRGHQL----------LTQEHVLRAVDVSPFADHPCT------------------------- 1821

  Fly  2859 IMSPDSKGCMDRNECLDMPCMNGATCINLEPR-LRYRCICPDGFWGENCE--LVQEGQTLKLSMG 2920
                         :.|..||:||.:|:   || ..|.|:||.||.|.:||  ||::      |:|
  Rat  1822 -------------QALGNPCLNGGSCV---PREATYECLCPGGFSGLHCEKGLVEK------SVG 1864

  Fly  2921 ALAAI 2925
            .|..:
  Rat  1865 DLETL 1869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	13/31 (42%)
		LamG	2385..2570	CDD:238058	50/186 (27%)
		EGF_2	<2605..2631	CDD:285248	9/26 (35%)
		Laminin_G_2	2665..2800	CDD:280389	29/145 (20%)
		EGF_CA	2869..2907	CDD:238011	15/38 (39%)
		Cadherin_C	2952..3088	CDD:279398
Agrn	XP_017448655.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910