DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Cdh6

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_037059.2	Gene:	Cdh6 / 25409	RGDID:	2322	Length:	790	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	202/784 - (25%)
Similarity:	332/784 - (42%)	Gaps:	186/784 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1548 DKDRPQ-NIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQP-------------NGRP 1598
            |:||.. ::.|.|:|.|      |...|.||..||:|...|.|||::.             .|||
  Rat    80 DQDRGDGSLKYILSGDG------AGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRP 138

  Fly  1599 QWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDD 1663
                   .:.|        ::..:.:.|||||.|||.:.||...|.|....|..|:.:||.|.||
  Rat   139 -------VEPE--------SEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADD 188

  Fly  1664 PNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GG 1724
            |..|::|::||||.:       |.|.|.:|.:||:||||:..:|||....|.:.:.|.|    .|
  Rat   189 PTYGNSAKVVYSILQ-------GQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMG 246

  Fly  1725 GLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDED--ETNKFQYKVI 1787
            ||.||.|.:|.:.|:||.||:|.:.   |...:|..::.|..||..:...|.|  |..:.:|.:.
  Rat   247 GLSGTTTVNITLTDVNDNPPRFPQS---TYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSIT 308

  Fly  1788 DNSGYGADKFTMVRNND-GTGSLKIVQPLDYEDQLQSNGFRFRIQVNDK---------GEDNDND 1842
            |  |.|.|.|.::.:.: ..|.:.:.:.||:|   :...:..:::.::.         |...|:
  Rat   309 D--GEGHDMFDVITDQETQEGIITVKKLLDFE---KKRVYTLKVEASNPHIEPRFLYLGPFKDS- 367

  Fly  1843 KYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRS 1907
                  :.|.:.:.|: |..|.|.:....:.:.||.::.|.:....|.||| ..::.|.||:||.
  Rat   368 ------ATVRIVVDDV-DEPPVFSKLAYILQIREDAQINTTIGSVAAQDPD-AARNPVKYSVDRH 424

  Fly  1908 SDRQRQFAINQ-NGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFL 1971
            :|..|.|.|:. |||:...:.||||.:..|.:.::|.:..:|.:::...|.:.|.|:|||||:|.
  Rat   425 TDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFA 489

  Fly  1972 KDYRPVLPEHVPPRKVVEIL-ATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDG 2035
            :.|...:.|.....::::.| |.|.||  ..:|..|.|.|.|.|..  .::|.::.::....|
  Rat   490 EFYETFVCEKAKADQLIQTLHAVDKDD--PYSGHQFSFSLAPEAAS--GSNFTIQDNKDNTAG-- 548

  Fly  2036 MAVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTV------------------------- 2075
              :::....::|.:...|::|:||.|:..|..:.|.|:||
  Rat   549 --ILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGL 611

  Fly  2076 ----------------------------------IIG--DVNDNKMQPGSKDIFVYNYQGQSPDT 2104
                                              ||.  |:.||        |..||.:|...:.
  Rat   612 STGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDN--------IVSYNDEGGGEED 668

  Fly  2105 PIGRVYVYDLDDWDLPDKKFYWEAMEHPRFKLD--EDSGMVTMRAGTREGRYHLRFKVYDR-KHT 2166
                ...:|:.....|      ||||..:.:.|  .::..:..|..|......:|..:..| |..
  Rat   669 ----TQAFDIGTLRNP------EAMEDSKSRRDIVPEALFLPRRTPTARDNTDVRDFISQRLKEN 723

  Fly  2167 QTDIPANVTVTVREIPHE---AVVNS----GSVRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDK 2224
            .||..|....::....:|   :|.:|    .||...|..|.|::..|.           .||: |
  Rat   724 DTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDGDQDYDYLSDWG-----------PRFK-K 776

  Fly  2225 LADL 2228
            |||:
  Rat   777 LADM 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	25/95 (26%)
		Cadherin_repeat	1638..1741	CDD:206637	42/106 (40%)
		Cadherin_repeat	1762..1861	CDD:206637	20/110 (18%)
		Cadherin_repeat	1871..1966	CDD:206637	30/95 (32%)
		Cadherin_repeat	1974..2083	CDD:206637	29/170 (17%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Cdh6	NP_037059.2	CA	79..157	CDD:214520	27/97 (28%)
		Cadherin_repeat	163..264	CDD:206637	43/107 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..288		10/31 (32%)
		Cadherin_repeat	272..379	CDD:206637	22/119 (18%)
		Cadherin_repeat	388..484	CDD:206637	30/96 (31%)
		Cadherin_repeat	492..589	CDD:206637	26/104 (25%)
		Cadherin_C	637..783	CDD:395833	39/174 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5067
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910