DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Cdh7

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001303672.1	Gene:	Cdh7 / 241201	MGIID:	2442792	Length:	785	Species:	Mus musculus

Alignment Length:	619	Identity:	192/619 - (31%)
Similarity:	297/619 - (47%)	Gaps:	94/619 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1516 PVFERPTYRTQ---------ITEEDDRNLPKRVLQVTATDGDKDRPQ-NIVYFLTGQGIDPDNPA 1570
            |.|:....||:         :.||...:.|   |.|.....|.|:.. :|.|.|:|:|      |
Mouse    36 PYFQSGRSRTKRSWVWNQFFVLEEYMGSDP---LYVGKLHSDVDKGDGSIKYILSGEG------A 91

  Fly  1571 NSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQ--DE-GGEGLVGYADVQVNLKDINDNAP 1632
            :|.|.|:..||:|...|.|||::     |..:|:.||  |. ..:.:...::..:.::|||||.|
Mouse    92 SSIFIIDENTGDIHATKRLDREE-----QAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEP 151

  Fly  1633 IFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTG 1697
            .|..|.|...|.|....|..|:.:||.|.|||..|::||:||||.:       |.|.|.:||.||
Mouse   152 KFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQ-------GQPYFSVEPKTG 209

  Fly  1698 VIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDET 1758
            |||||:..:|||....|.:.:.|.|    .|||.||.:.::.:.|:||.||:|.:..:...|.|:
Mouse   210 VIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPES 274

  Fly  1759 DGTALPEMPILTVTVH------DEDETNKFQYKVIDNSGYG-----ADKFTMVRNNDGTGSLKIV 1812
                   :|:.:|...      |.....:.:||::|..|.|     |||.|.      .|.:.|.
Mouse   275 -------LPVASVVARIKAADADIGVNAEMEYKIVDGDGLGIFKISADKDTQ------EGIITIQ 326

  Fly  1813 QPLDYEDQLQSNGFRFRIQVNDKGED---------NDNDKYHVAYSWVVVKLRDINDNKPHFERA 1868
            :.||:|   ....:..||:..::..|         :|.       :.|.:.:.|: |..|.|...
Mouse   327 KELDFE---AKTSYTLRIEAANRDADPRFLSLGPFSDT-------TTVKIIVEDV-DEPPVFSSP 380

  Fly  1869 NVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQN-GSVTIQRSLDREV 1932
            ...:.|.|.|:||..:....|.||| ...|.|.|||||::|.:|.|.|:.| |.:|..:|||||.
Mouse   381 LYPMEVSEATQVGHIIGTVAAHDPD-SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET 444

  Fly  1933 VPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVE-ILATDDD 1996
            ...|.:.:||::..:|.:.....:.:.:.|||||||:|..||...:.|:..|.:|:: |.|.|.|
Mouse   445 NAVHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKD 509

  Fly  1997 DRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKD 2061
            :  .|||..|.|.|.....:....|.|..:|...      ::::....|.|::|..|.:||.|.|
Mouse   510 E--PSNGHQFYFSLTTDMTNNHNFSLKDNKDNTA------SILTRRNGFRRQEQSVYYLPIFIVD 566

  Fly  2062 HGSPAMTGTSTLTVIIGDVN-DNKMQPGSKDIFV 2094
            .|||:::.|:|||:.:.|.: |...|..:.:.:|
Mouse   567 SGSPSLSSTNTLTIRVCDCDADGIAQTCNAEAYV 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	33/120 (28%)
		Cadherin_repeat	1638..1741	CDD:206637	42/106 (40%)
		Cadherin_repeat	1762..1861	CDD:206637	23/118 (19%)
		Cadherin_repeat	1871..1966	CDD:206637	35/95 (37%)
		Cadherin_repeat	1974..2083	CDD:206637	33/110 (30%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Cdh7	NP_001303672.1	CA	73..151	CDD:214520	28/88 (32%)
		Cadherin_repeat	157..258	CDD:206637	43/107 (40%)
		Cadherin_repeat	266..373	CDD:206637	25/130 (19%)
		Cadherin_repeat	382..478	CDD:206637	35/96 (36%)
		Cadherin_repeat	486..584	CDD:206637	32/105 (30%)
		Cadherin_C	631..779	CDD:395833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910