Protein Alignment CadN and Cdh24

DIOPT Version :10

• Sequence 1: NP_001027277.1
• Gene: CadN / 35070
• FlyBaseID: FBgn0015609
• Length: 3101
• Species: Drosophila melanogaster
• Sequence 2: NP_955764.1
• Gene: Cdh24 / 239096
• MGIID: 1928330
• Length: 781
• Species: Mus musculus
• Alignment Length: 562
• Identity: 163/562 - (29%)
• Similarity: 275/562 - (48%)
• Gaps: 65/562 - (11%)

  Fly  1536 PKRVLQVTATDGDKDRPQ-NIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQ 1599
            |:.|| :.....|.||.: ...|.|||:|      |.:.|.|:..||.|.|.|.|||::   :.|
Mouse    60 PEPVL-IGKLHSDVDRGEGRTKYLLTGEG------AGTVFVIDEATGNIHVTKSLDREE---KAQ 114

  Fly  1600 WRFTVFAQDE-GGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDD 1663
            :.....|.|. ....|...::..:.::|||||.|:||.|.|...|.|....|..|:.:||.|.||
Mouse   115 YVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPVFPLGPYHATVPEMSNVGTSVIQVTAHDADD 179

  Fly  1664 PNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GG 1724
            |:.|::|:|||::       ..|.|.|.::|.|||::||:..:|||...::.:.:.|.|    .|
Mouse   180 PSYGNSAKLVYTV-------LDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMG 237

  Fly  1725 GLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDED--ETNKFQYKVI 1787
            ||.|:.|.::.:.|:||.||:|.:..:...|.||.|   |...:..:...|.|  :.....|.::
Mouse   238 GLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAG---PGTLVGRLKAQDPDLGDNALVAYSIL 299

  Fly  1788 DNSGYGADKFTMVRNNDG-TGSLKIVQPLDYEDQLQSNGFRFRIQVND---------KGEDNDND 1842
              :|.|::.|::..::.| .|.|.:.:|||:|.:   ..:.||::..:         :|...|
Mouse   300 --NGEGSEVFSISTDSQGQDGLLTVRKPLDFETR---RSYTFRVEATNTLIDPAYLRRGPFKD-- 357

  Fly  1843 KYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRS 1907
                 .:.|.|.::|..: .|.|.:|...::|.|:...||.:.:..|:|.|... |.:.|||...
Mouse   358 -----VASVRVTVQDAPE-PPAFTQATYHLAVPENKAPGTLVGQISASDLDSPA-SPIRYSILPH 415

  Fly  1908 SDRQRQFAIN-QNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFL 1971
            ||.:|.|:|. ::|::.....||||....|.:.|||.:..|..:::...:.:...|.|||||:..
Mouse   416 SDPERCFSIEPEDGTIRTAVRLDREARVWHNLTILATELDSSAQSSRVQVAIQTLDENDNAPQLA 480

  Fly  1972 KDYRPVLPEHVPPRKVVEIL-ATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDG 2035
            :.|...:.:...|.:::::: |.|.|:...|:....|..:.|.|:..:|           .|.||
Mouse   481 EPYDIFVCDSAAPGQLIKVIRALDRDEVGNSSQVSLQGPVGPDANFTVR-----------DNRDG 534

  Fly  2036 MAVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTVII 2077
            .|.:.........:|..|:|||.:.|.|.||::.|:|:||.:
Mouse   535 SASLLLPSRPAPPRQAPYLIPIELWDWGQPALSSTATVTVSV 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		CA_like	449..541	CDD:481204
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	29/95 (31%)
		Cadherin_repeat	1638..1741	CDD:206637	36/106 (34%)
		CA	1770..1863	CDD:214520	20/104 (19%)
		Cadherin_repeat	1871..1966	CDD:206637	28/95 (29%)
		Cadherin_repeat	1974..2083	CDD:206637	27/105 (26%)
		EGF	2350..2380	CDD:394967
		LamG	2385..2570	CDD:238058
		EGF_2	2605..2631	CDD:400365
		LamG	2637..2797	CDD:238058
		EGF_CA	2869..2907	CDD:238011
		CADH_Y-type_LIR	3029..3088	CDD:460041
Cdh24	NP_955764.1	CA	70..148	CDD:214520	28/86 (33%)
		Cadherin_repeat	154..255	CDD:206637	37/107 (35%)
		Cadherin_repeat	264..368	CDD:206637	24/118 (20%)
		Cadherin_repeat	378..475	CDD:206637	28/97 (29%)
		CA_like	483..577	CDD:481204	27/105 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	665..700
		CADH_Y-type_LIR	713..774	CDD:460041
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	731..762