DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Cdh24

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_955764.1	Gene:	Cdh24 / 239096	MGIID:	1928330	Length:	781	Species:	Mus musculus

Alignment Length:	562	Identity:	163/562 - (29%)
Similarity:	275/562 - (48%)	Gaps:	65/562 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1536 PKRVLQVTATDGDKDRPQ-NIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQ 1599
            |:.|| :.....|.||.: ...|.|||:|      |.:.|.|:..||.|.|.|.|||::   :.|
Mouse    60 PEPVL-IGKLHSDVDRGEGRTKYLLTGEG------AGTVFVIDEATGNIHVTKSLDREE---KAQ 114

  Fly  1600 WRFTVFAQDE-GGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDD 1663
            :.....|.|. ....|...::..:.::|||||.|:||.|.|...|.|....|..|:.:||.|.||
Mouse   115 YVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPVFPLGPYHATVPEMSNVGTSVIQVTAHDADD 179

  Fly  1664 PNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GG 1724
            |:.|::|:|||::       ..|.|.|.::|.|||::||:..:|||...::.:.:.|.|    .|
Mouse   180 PSYGNSAKLVYTV-------LDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMG 237

  Fly  1725 GLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDED--ETNKFQYKVI 1787
            ||.|:.|.::.:.|:||.||:|.:..:...|.||.|   |...:..:...|.|  :.....|.::
Mouse   238 GLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAG---PGTLVGRLKAQDPDLGDNALVAYSIL 299

  Fly  1788 DNSGYGADKFTMVRNNDG-TGSLKIVQPLDYEDQLQSNGFRFRIQVND---------KGEDNDND 1842
              :|.|::.|::..::.| .|.|.:.:|||:|.:   ..:.||::..:         :|...|
Mouse   300 --NGEGSEVFSISTDSQGQDGLLTVRKPLDFETR---RSYTFRVEATNTLIDPAYLRRGPFKD-- 357

  Fly  1843 KYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRS 1907
                 .:.|.|.::|..: .|.|.:|...::|.|:...||.:.:..|:|.|... |.:.|||...
Mouse   358 -----VASVRVTVQDAPE-PPAFTQATYHLAVPENKAPGTLVGQISASDLDSPA-SPIRYSILPH 415

  Fly  1908 SDRQRQFAIN-QNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFL 1971
            ||.:|.|:|. ::|::.....||||....|.:.|||.:..|..:::...:.:...|.|||||:..
Mouse   416 SDPERCFSIEPEDGTIRTAVRLDREARVWHNLTILATELDSSAQSSRVQVAIQTLDENDNAPQLA 480

  Fly  1972 KDYRPVLPEHVPPRKVVEIL-ATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDG 2035
            :.|...:.:...|.:::::: |.|.|:...|:....|..:.|.|:..:|           .|.||
Mouse   481 EPYDIFVCDSAAPGQLIKVIRALDRDEVGNSSQVSLQGPVGPDANFTVR-----------DNRDG 534

  Fly  2036 MAVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTVII 2077
            .|.:.........:|..|:|||.:.|.|.||::.|:|:||.:
Mouse   535 SASLLLPSRPAPPRQAPYLIPIELWDWGQPALSSTATVTVSV 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	29/95 (31%)
		Cadherin_repeat	1638..1741	CDD:206637	36/106 (34%)
		Cadherin_repeat	1762..1861	CDD:206637	21/110 (19%)
		Cadherin_repeat	1871..1966	CDD:206637	28/95 (29%)
		Cadherin_repeat	1974..2083	CDD:206637	27/105 (26%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Cdh24	NP_955764.1	CA	70..148	CDD:214520	28/86 (33%)
		Cadherin_repeat	154..255	CDD:206637	37/107 (35%)
		Cadherin_repeat	264..368	CDD:206637	24/118 (20%)
		Cadherin_repeat	378..475	CDD:206637	28/97 (29%)
		Cadherin	485..577	CDD:356102	26/103 (25%)
		Cadherin_C	625..776	CDD:366437
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..700
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..762
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910