DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and CRB1

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_016856341.1	Gene:	CRB1 / 23418	HGNCID:	2343	Length:	1451	Species:	Homo sapiens

Alignment Length:	781	Identity:	179/781 - (22%)
Similarity:	285/781 - (36%)	Gaps:	204/781 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2230 NTERENVDIFSVQLKRKHPPLTDV--RFSAHGSPYYKPVRLNGIVLMHREEIEKDVGINITMVGI 2292
            |..:.|.:...:..::::..:|.:  .||.|.:..|..:...|...:|.||            .:
Human   346 NPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEE------------DV 398

  Fly  2293 DECLYENQMCE--GSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNFTKP-------- 2347
            :||  .:..|:  |:|.|      ||    .|.|            |.|...|.::.
Human   399 NEC--SSNPCQNGGTCEN------LP----GNYT------------CHCPFDNLSRTFYGGRDCS 439

  Fly  2348 ---ESCRTTPCHNGGRCV----DTRFGPHCSCPVGYTGPRCQ-QTTRSFRGNGWAWYPPLEMCDE 2404
               ..|....|.|.|.|:    |.:.|..|.||.||||..|: .||.||.|:|:.|.....:..:
Human   440 DILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSFEGDGFLWVKSGSVTTK 504

  Fly  2405 S---HLSLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKT 2466
            .   :::|.|.|.:|..|:::..     .||.     |:.|||..||..|.|...:.:..|...:
Human   505 GSVCNIALRFQTVQPMALLLFRS-----NRDV-----FVKLELLSGYIHLSIQVNNQSKVLLFIS 559

  Fly  2467 KKTLDDGEWHRID-LFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNV 2530
            ..| .|||||.:: :|.:..::.::.|.||...||:..  ||.|.|...|..:      |.:|
Human   560 HNT-SDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAP--TPLESDQSICAFQ------NSFL-- 613

  Fly  2531 NAPLQVG----GLYREQFDQSLYFWHYMPTAKGFDGCIRNLV--HNSKLYDLAHPGLSRNSVAGC 2589
             ..|.||    |:       :|..::.||:...|.||::::.  .|....:....|.|.|..|||
Human   614 -GGLPVGMTSNGV-------ALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAGC 670

  Fly  2590 PQTEEVCAQTETTARCWEHGNCVGSLSEARCHCRPGWTGPACNIPTIPTTFKAQSYVKYALSFEP 2654
            .:.:...:|.     |...|.|:......:|.|...:.||.|....:...|.......|.:....
Human   671 VRKDWCESQP-----CQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLD 730

  Fly  2655 DRFSTQVQLRF--RTREEYGELFRVSDQHNREYGILEI--KDGHLHFRYNLNSLRTEEKDLWLNA 2715
            :.:...:.|..  ||.:..|.|..:   .|..|..:.:  :.|.|       ::.|......:..
Human   731 ESYGDTISLSMFVRTLQPSGLLLAL---ENSTYQYIRVWLERGRL-------AMLTPNSPKLVVK 785

  Fly  2716 IVVNDGQWHVV-------KVNRYGSAATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVYAGGKA 2773
            .|:|||..|::       |:..|.|:..|              .|:......::|.:.:|.||..
Human   786 FVLNDGNVHLISLKIKPYKIELYQSSQNL--------------GFISASTWKIEKGDVIYIGGLP 836

  Fly  2774 EYTGVRTFEVYADYQKSCLDDIRLEGKHLPL-----------PPAMNGTQW--GQATMARNLEKG 2825
            :   .:..|:...:.|.|:.|:||..::|..           |..:|.||.  |..:..|....|
Human   837 D---KQETELNGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNSCKRQTNVG 898

  Fly  2826 --------------------C------------PSNKPCSNVICPDPFECVDLWNVYECTCGEGR 2858
                                |            .|.||.||. |.:...|...|:.:.|:|
Human   899 RALTELGSRGPKYQVSLFRFCVGSWATGNTFFLSSIKPGSNP-CHNGGVCHSRWDDFSCSC---- 958

  Fly  2859 IMSP---DSKGCMDRNECLDMPCMNGATCINLEPRLR-YRCICPDGFWGENCELVQEGQTLKLSM 2919
               |   ..|.|.:...|...||.:||.|   :|.|: :.||....|.|      |.||.|..|.
Human   959 ---PALTSGKACEEVQWCGFSPCPHGAQC---QPVLQGFECIANAVFNG------QSGQILFRSN 1011

  Fly  2920 G 2920
            |
Human  1012 G 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	14/33 (42%)
		LamG	2385..2570	CDD:238058	51/194 (26%)
		EGF_2	<2605..2631	CDD:285248	7/25 (28%)
		Laminin_G_2	2665..2800	CDD:280389	29/145 (20%)
		EGF_CA	2869..2907	CDD:238011	12/38 (32%)
		Cadherin_C	2952..3088	CDD:279398
CRB1	XP_016856341.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910