DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Cdh19

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001074855.1	Gene:	Cdh19 / 227485	MGIID:	3588198	Length:	770	Species:	Mus musculus

Alignment Length:	545	Identity:	158/545 - (28%)
Similarity:	271/545 - (49%)	Gaps:	62/545 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1565 DPDNPANS-----------KFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQ---DEGGEGLV 1615
            |.||..||           .|.||..||||..::.|||::.:     .:.:.||   ...|:.:.
Mouse    68 DLDNGNNSFQYKLLGIGAGSFSINERTGEICAIQKLDREEKS-----LYILRAQVIDTTIGKAVE 127

  Fly  1616 GYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNV 1680
            ..::..:.:.|||||.|.|....|...|.|....|..|:.:||.|.|||:.|.:||::|::|:
Mouse   128 TESEFVIRVLDINDNEPRFLDEPYEAIVPEMSPEGTFVIKVTANDADDPSTGYHARILYNLER-- 190

  Fly  1681 IEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDIND 1741
                 |.|.|.:||.||||:.: ..:|||....|.:.:.|.|    .|.|.||.|.||::.||||
Mouse   191 -----GQPYFSVEPTTGVIRIS-SKMDRELQDTYCVIIQAKDMLGQPGALSGTTTVSIKLSDIND 249

  Fly  1742 MPPQFTKDEWFTEVDETD--GTALPEMPILTVTVHDED--ETNKFQYKVIDNSGYGADKFTMVRN 1802
            ..|.|.:..:...:.|:.  ||::.:     :..:|:|  |..:.:|.:.|:.   :..|.::.:
Mouse   250 NKPIFKESFYRFTISESAPIGTSIGK-----IMAYDDDIGENAEMEYSIEDDD---SKIFDIIID 306

  Fly  1803 NDGTGSLKIV-QPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLR-DINDNKPHF 1865
            ||....:.|: :.:|:|   |.:.:..|.:|.:...|.:....||..|...:|:: :..|..|.|
Mouse   307 NDTQEGIVILKKKVDFE---QQSYYGIRAKVKNCHVDEELAPAHVNASTTYIKVQVEDEDEPPVF 368

  Fly  1866 ERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQNGSVTIQRSLDR 1930
            ......:.:.|....||.:....|||||: .:|.:.|.:..|    :.|.||.||::.....|||
Mouse   369 LLPYYILEIPEGKPYGTIVGTVSATDPDR-RQSPMRYYLTGS----KMFDINDNGTIITTNMLDR 428

  Fly  1931 EVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEILATDD 1995
            ||...:.:.:.|.:..:..:.::|.:.|.|.:||||||:|.:.|...:.|:....::|:|::..|
Mouse   429 EVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNAPEFSQFYETYVCENAESGEIVQIISAID 493

  Fly  1996 DDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRS-FDREQQKEYMIPIVI 2059
            .|.|..:   ..|..:.|.:|...:||.:..:|     |..|||.|.|: |:.:::..:.:.|:|
Mouse   494 RDESIED---HHFYFNHSLEDTNNSSFMLTDNQ-----DNTAVILSNRTGFNLKEEPVFYMIILI 550

  Fly  2060 KDHGSPAMTGTSTLTVIIGDVNDNK 2084
            .|:|.|::|.|:|||:.:.|..|::
Mouse   551 ADNGIPSLTSTNTLTIQVCDCGDSR 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	21/78 (27%)
		Cadherin_repeat	1638..1741	CDD:206637	40/106 (38%)
		Cadherin_repeat	1762..1861	CDD:206637	19/102 (19%)
		Cadherin_repeat	1871..1966	CDD:206637	27/94 (29%)
		Cadherin_repeat	1974..2083	CDD:206637	31/109 (28%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Cdh19	NP_001074855.1	Cadherin_repeat	50..142	CDD:206637	21/78 (27%)
		Cadherin_repeat	150..250	CDD:206637	41/107 (38%)
		Cadherin_repeat	259..364	CDD:206637	22/115 (19%)
		Cadherin_repeat	373..464	CDD:206637	27/95 (28%)
		Cadherin_repeat	472..570	CDD:206637	30/105 (29%)
		Cadherin_C	617..764	CDD:395833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910