DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and Cdh23

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:XP_017169419.1 Gene:Cdh23 / 22295 MGIID:1890219 Length:3361 Species:Mus musculus


Alignment Length:2431 Identity:647/2431 - (26%)
Similarity:980/2431 - (40%) Gaps:444/2431 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 EMSLVLPHDTYPGFSIKKFKTHPVKINGSSHSGAAAYHMLDTDYS-------KY--------FTV 120
            :::|:..:|..|.||...:.   |.:..:...|.:...:|.||..       .|        |::
Mouse   454 KITLINENDNRPIFSQPLYN---VSLYENITVGTSVLTVLATDNDVGTFGEVNYFFSDDPDRFSL 515

  Fly   121 LED-GVVMTTADIS-PLVNRPVQLVVVEQTPNATNTHNLQLFVMHRNDML-RFSGSLLDA-SGEV 181
            .:| |::|..|.:. .|:.|....|:.........|..:::.|:..||.: .|.   .|| .|.:
Mouse   516 DKDTGLIMLIARLDYELIQRFTLTVIARDGGGEETTGRVRINVLDVNDNVPTFQ---KDAYVGAL 577

  Fly   182 RENQPAGT---RVRGVPLMQAFSGSILDEELATPKKVRYTIIDGNVDDAF--------------- 228
            |||:|:.|   |:|..           ||:......:.|:|::.:...::               
Mouse   578 RENEPSVTQLVRLRAT-----------DEDSPPNNLITYSIVNASAFGSYFDISIYEGYGVISVS 631

  Fly   229 ----------------ALQERKAN---------------------------------KNIQISAK 244
                            .:.:...|                                 :||...|.
Mouse   632 RPLDYEQIPNGLIYLTVMAKDAGNPPLYSTVPVTIEVFDENDNPPTFSKPAYFVSVLENIMAGAT 696

  Fly   245 SLVINGDD---------ESGVW----------------LVTNRPLDREERAHYDLSVEASD--VD 282
            .|.:|..|         ||.::                :.|...||||.::.|.|.|.|.|  |.
Mouse   697 VLFLNATDLDRSREYGQESIIYSLEGSSQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVG 761

  Fly   283 GLDRT-VSKIQITVLDENDNRPIFKSLDYKFAIAGQKSASMESNSSVTYQRFAIMGKVEATDAD- 345
            ...:| ::.:.:|:||.|||.|.:|...|...:.    .....:|.||        .|.|.|.| 
Mouse   762 HNQKTGIATVNVTLLDINDNHPTWKDAPYYINLV----EMTPPDSDVT--------TVVAVDPDL 814

  Fly   346 GDK--IAYRLKSPSNVVIIVPQTGEI-----MLAGE---PTSNELLIEVIAH--DLRYPSLVSAK 398
            |:.  :.|.:..|:....:...||:|     ||..|   |...||:.::|..  |...|.|.:..
Mouse   815 GENGTLVYSIHPPNKFYSLNSTTGKIRTTHVMLDRENPDPVEAELMRKIIVSVTDCGRPPLKATS 879

  Fly   399 PAKVLLEFLAAEPVSFIMQHLEHDDINNHSHHREKRRVTRAVRPT-KRIEFTE--ADGDTEGKSV 460
            .|.|.:..|               |:|::.             || :.:.|..  .:|...|.||
Mouse   880 SATVFVNLL---------------DLNDND-------------PTFRNLPFVAEILEGTPAGVSV 916

  Fly   461 FQL------EKETDKETFKIRDDNP---WVTVETNGAVRVKKKWDYEELGPEKTIDFWVIITNMG 516
            :|:      |......:::::...|   :|...|:|.|....:.|.|.:...:       :..:.
Mouse   917 YQVVAIDLDEGLNGLVSYRMQVGMPRMDFVINSTSGVVTTTAELDRERIAEYQ-------LRVVA 974

  Fly   517 HNAGI-KYTDNQRVIILVKDVNDEPPYFINRPLPMQAVVQLNAPPNTPVFTLQARDPDTDHN--I 578
            .:||. ..:....:.:.|.|||||.|.|.  |......|..:.|....|..|...|.|...|  :
Mouse   975 SDAGTPTKSSTSTLTVRVLDVNDETPTFF--PAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAEL 1037

  Fly   579 HYFIVRDRTGGRFEVDERSGVVRTRGTDLFQLDME----YVLYVKAEDQNGKVDDRRFQSTPEER 639
            .|||......|:|.|..|..||||    :..||.|    |.|.::|.| ||.|..|| ..|....
Mouse  1038 SYFITAGNVDGKFSVGYRDAVVRT----VVGLDRETTAAYTLVLEAID-NGPVGKRR-TGTATVF 1096

  Fly   640 LSIVG-GKRAPQFYMPSYEAEIPENQKKDSDIISIKAKSFADRE---IRYTLKAQGQGAGTFNIG 700
            ::::. ....|.|...||||.:||:..:...|:.:||....:.|   :.|.: ..|.....|.|.
Mouse  1097 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSIVQLKATDADEGEFGRVWYRI-LHGNHGNNFRIH 1160

  Fly   701 PTSG-IVKLAKELDFEDLRQPHVYSLIVTA-TEDSGGFSTSVDLTIRVTDVNDNAPKFELPDYQA 763
            ..|| :::..:.|| .:....||  |:|.| ..|.|...:||.:.:.|.||||.||.|....|..
Mouse  1161 VGSGLLMRGPRPLD-RERNSSHV--LMVEAYNHDLGPMRSSVRVIVYVEDVNDEAPVFTQQQYNR 1222

  Fly   764 HNVDEDIPLGTSILRVKAMDSDSGSNAEIEYLV---SDDHFAVD-SNGIIVNNKQLDADNNNAYY 824
            ..:.|...:|||::.|:|.|.|:|....:.|.:   ::..|.:| |.|:||....||.:...:|.
Mouse  1223 LGLRETAGIGTSVIVVRATDKDTGDGGLVNYRILSGAEGKFEIDESTGLIVTVDYLDYETKTSYL 1287

  Fly   825 EFIVTAKDKGEPPKSGVATVRVYTKNKNDEEPKFSQQVYTPNVDENAGPNTLVTTVVASDKDGDN 889
             ..|:|.|...|...|..:|.|...|:.||..:||...|...:.||....|.:..|.|...|..|
Mouse  1288 -MNVSATDGAPPFNQGFCSVYVTLLNELDEAVQFSNASYEAVIMENLALGTEIVRVQAYSIDNLN 1351

  Fly   890 ---VRFGFVGGGTSSGQFVIEDITGVIRLHNKAISLDKDK---YELNVTAMDDGSCCVNGDQTIH 948
               .||.......:...|.|:.|||||.:  |.: :|::|   |.|.|.| |||...|:      
Mouse  1352 QITYRFDAYTSAQAKALFKIDAITGVITV--KGL-VDREKGDFYTLTVVA-DDGGPKVD------ 1406

  Fly   949 TSTAVVVVFITDVNDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPN 1013
             ||..|.:.:.|.|||.|.|...|.....|.|..|.|..|..|.|.|.|.|.||||.:|:. ..|
Mouse  1407 -STVKVYITVLDENDNSPRFDFTSDSAISVPEDCPVGQRVATVKARDPDAGSNGQVVFSLA-SGN 1469

  Fly  1014 QKGT--KFTVDEETGEVSTNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPP 1076
            ..|.  ..|.::..|||...|..|||..|...:.|.  |:|:|.|..:......|.|.|||||||
Mouse  1470 IAGAFEIITSNDSIGEVFVAKPLDREELDHYILKVV--ASDRGTPPRKKDHILQVTILDVNDNPP 1532

  Fly  1077 LFDRQ-KYVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVL 1140
            :.:.. .|..:|.::...||::::|.|:|.|...|..:.|.:|   ..|:...|.:...||.|..
Mouse  1533 VIESPFGYNVSVNENVGGGTSVVQVRATDRDIGINSVLSYYIT---EGNEDMTFRMDRISGEIAT 1594

  Fly  1141 KKPLDGCYPRDR-----YRLRVSASDKGTPASAADVDVELDVVDRNNKPPIWDKSIYGPIHIREN 1200
            :..     |.||     |.|.|:..|:|||..:|...|.:.:||.|:..|::.:..|..:.....
Mouse  1595 RPA-----PPDRERQNFYHLVVTVEDEGTPTLSATTHVYVTIVDENDNAPVFQQPHYEVVLDEGP 1654

  Fly  1201 VTVGTVVTSVKASSGIEG-NPTVFYRLMPG---STAQTNKFHTFYLQQRPDNGDTWADIKVNHPL 1261
            .|:.|.:.:|:|....|| |.||.|.::.|   :|.:.|| ||             ..|.....|
Mouse  1655 DTINTSLITVQALDLDEGPNGTVTYAIVAGNIINTFRINK-HT-------------GVITAAKEL 1705

  Fly  1262 DYE-SIKEYNLTIRVENNG---AQQLASEATVYIMLEDVNDEIPLFTEREQE---TVLEGEPIGT 1319
            ||| |...|.|.:...:..   :.:|.|..||.:.:.|:||.:|.| .|:.|   .|.||:| |.
Mouse  1706 DYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTF-PRDYEGPFDVTEGQP-GP 1768

  Fly  1320 KVTQVNAIDKDGTFPNNQVYYYIVD-SPRNEGKEFFEINLQSGEIFTK--TVFDREKKGAYALEV 1381
            :|....|.|:| :.||.||.|.:|| .|..|    |.|:...|.:..:  ...|||....|.|.:
Mouse  1769 RVWTFLAHDRD-SGPNGQVEYSVVDGDPLGE----FVISPVEGVLRVRKDVELDRETIAFYNLTI 1828

  Fly  1382 EARD-GAPSARPNSNGPNSVTKFIRIGIADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDH 1445
            .||| |.|        |.|.|..:.|.:.|.|||.|..........:.||..:...|..|.|.|.
Mouse  1829 CARDRGVP--------PLSSTMLVGIRVLDINDNDPVLLNLPMNVTISENSPVSSFVAHVLASDA 1885

  Fly  1446 DE--SSRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELRLAASDN------LKENYT 1502
            |.  ::.:.:.||:||...||.:...||.:.|...||.|....|.|.::..||      .::::.
Mouse  1886 DSGCNALLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYRLTVSVKDNPENPRIARKDFD 1950

  Fly  1503 TVIIHVKDVNDNPPVFERPTYRTQITEEDDRNLPKRVLQ--VTATDGDKDRPQNIVYFLTGQGID 1565
            .:::.:.|.|||.|:|...||:.::.|......|..||.  :.|.|.|:|....:.|.|.|...|
Mouse  1951 LLLVSLADENDNHPLFTEGTYQAEVMENSPAGTPLTVLNGPILALDADEDVYAVVTYQLLGTHSD 2015

  Fly  1566 PDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQW-RFTVFAQDEGGEGLVGYADVQVNLKDIND 1629
                   .|.|:.:||.:.|...:..|:....|.: ...:.|:|.|  .|.|.|.:.:.:.|.||
Mouse  2016 -------LFVIDNSTGVVTVRSGIIIDREAFSPPFLELLLLAEDIG--QLNGTAHLFITILDDND 2071

  Fly  1630 NAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEP 1694
            |.|.|....|..::.||...|..|:.:||.|.|   .|.|..|||.||....:.      |.|.|
Mouse  2072 NWPTFSPPTYTVHLLENCPPGFSVLQVTATDED---SGLNGELVYRIEAGAQDR------FLIHP 2127

  Fly  1695 DTGVIKTAVCCLDRERTPDYSIQVVAMDGG--GLKGTGTASIRVKDINDMPPQFTKDEWFTEVDE 1757
            .||||:.....:|||....|.:.|||.|.|  .|.||...:|.:.||||..|:|........|.|
Mouse  2128 VTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLE 2192

  Fly  1758 TDGTALPEMPILTVTVHDEDETNKFQYKVI------DNSGYGADKFTMVRNNDGTGSLKIVQPLD 1816
               :|.|...|..||..|.|...|.:|.:|      |......|:......|..|||:.:..||:
Mouse  2193 ---SAEPGTIIANVTAIDLDLNPKLEYHIISIVAKDDTDRLVPDQEDAFAVNINTGSVMVKSPLN 2254

  Fly  1817 YEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEV---SVFEDT 1878
            .|  |.:. :...:.|.|...|.......|..:.:.|.:.|:|||.|.|:...:..   .|.|..
Mouse  2255 RE--LVAT-YEVTLSVIDNASDLPEHSVSVPNAKLTVNILDVNDNTPQFKPFGITYYTERVLEGA 2316

  Fly  1879 KVGTELEKFKATDPDQGGKSKVSYS-IDRSSDRQRQFAINQNGSVTIQRSLDREVVPRHQVKILA 1942
            ..||.|....|.|||:|....::|: :|.:.....|...:..|.|...|::|.|.|......:.|
Mouse  2317 TPGTTLIAVAAVDPDKGLNGLITYTLLDLTPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRA 2381

  Fly  1943 IDDGSPPKTATATLTVIVQDINDNAPKF-LKDYRPVLPEHVPPRKVV-EILATDDD-------DR 1998
            .|:||||:.|...:.:.:.|||||.|.| ...|:..:.|.:....|: .:.|||.|       :.
Mouse  2382 SDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDIAVGTVILRVTATDADSGNFALIEY 2446

  Fly  1999 SKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKDHG 2063
            |..:|.. :|.::|:..||                   :|:|||   |||::..|::..:.||:.
Mouse  2447 SLVDGEG-KFAINPNTGDI-------------------SVLSSL---DREKKDHYILTALAKDNP 2488

  Fly  2064 SPAMTG--TSTLTVIIG--DVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYVYDLDDWDLPDKKF 2124
            ....:.  .:::.|:|.  ||||.:.|..........|:.:...|.:..:...|.|:.......:
Mouse  2489 GDVASNRRENSVQVVIRVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMLATDQDEGSNSQLTY 2553

  Fly  2125 YWEAMEHPRFKLDEDSGMVTMRAGTRE-GRYHLRFKVYDRKHTQ-----------TDIPANVTVT 2177
            ..|......|.:|.|||:||.:...:. .|::|.....|.....           .|:..|..|.
Mouse  2554 SLEGPGMEAFSVDMDSGLVTTQRPLQSYERFNLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVF 2618

  Fly  2178 VR-----------EIP-----HEAVVNSGSVRLSGISDEDFI-----RVWNYRTQSMSRSKMDRF 2221
            ||           |||     :|.........|:|.....|:     |.|.|.|           
Mouse  2619 VRPPNGTILHIKEEIPLRSNVYEVYATDNDEGLNGAVRYSFLKTTGNRDWEYFT----------- 2672

  Fly  2222 RDKLADLLNT----ERENVDIFSVQL 2243
            .|.::.|:.|    :||...::|:.|
Mouse  2673 IDPISGLIQTAQRLDREKQAVYSLIL 2698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637 37/217 (17%)
Cadherin_repeat 337..396 CDD:206637 20/71 (28%)
E_set 449..541 CDD:298831 21/103 (20%)
Cadherin_repeat 549..>625 CDD:206637 25/81 (31%)
Cadherin_repeat 655..752 CDD:206637 31/101 (31%)
Cadherin_repeat 765..853 CDD:206637 27/91 (30%)
Cadherin_repeat 862..964 CDD:206637 33/107 (31%)
Cadherin_repeat 973..1074 CDD:206637 36/102 (35%)
Cadherin_repeat 1083..1166 CDD:206637 25/87 (29%)
Cadherin_repeat <1219..1298 CDD:206637 23/85 (27%)
Cadherin_repeat 1310..1414 CDD:206637 37/107 (35%)
Cadherin_repeat 1423..1514 CDD:206637 25/98 (26%)
Cadherin_repeat 1522..1630 CDD:206637 29/110 (26%)
Cadherin_repeat 1638..1741 CDD:206637 38/104 (37%)
Cadherin_repeat 1762..1861 CDD:206637 27/104 (26%)
Cadherin_repeat 1871..1966 CDD:206637 29/98 (30%)
Cadherin_repeat 1974..2083 CDD:206637 28/120 (23%)
EGF 2350..2380 CDD:278437
LamG 2385..2570 CDD:238058
EGF_2 <2605..2631 CDD:285248
Laminin_G_2 2665..2800 CDD:280389
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
Cdh23XP_017169419.1 Cadherin_repeat 51..137 CDD:206637
Cadherin_repeat 145..240 CDD:206637
Cadherin_repeat 249..353 CDD:206637
Cadherin_repeat 361..463 CDD:206637 1/8 (13%)
Cadherin_repeat 472..564 CDD:206637 17/94 (18%)
Cadherin_repeat 573..674 CDD:206637 13/111 (12%)
Cadherin_repeat 683..781 CDD:206637 24/97 (25%)
Cadherin_repeat 789..893 CDD:206637 29/130 (22%)
Cadherin_repeat 901..997 CDD:206637 19/102 (19%)
Cadherin_repeat 1006..1105 CDD:206637 31/104 (30%)
Cadherin_repeat 1113..1210 CDD:206637 30/100 (30%)
Cadherin_repeat 1225..1315 CDD:206637 27/90 (30%)
Cadherin_repeat 1324..1421 CDD:206637 33/107 (31%)
Cadherin_repeat 1433..1530 CDD:206637 36/99 (36%)
Cadherin_repeat 1540..1637 CDD:206637 31/104 (30%)
Cadherin_repeat 1645..1747 CDD:206637 31/115 (27%)
Cadherin_repeat 1759..1854 CDD:206637 37/108 (34%)
Cadherin_repeat 1862..1962 CDD:206637 25/99 (25%)
Cadherin_repeat 1970..2072 CDD:206637 29/110 (26%)
Cadherin_repeat 2080..2176 CDD:206637 38/104 (37%)
Cadherin_repeat 2187..2296 CDD:206637 29/114 (25%)
Cadherin_repeat 2308..2405 CDD:206637 29/96 (30%)
Cadherin_repeat 2413..2511 CDD:206637 27/120 (23%)
Cadherin_repeat 2520..2614 CDD:206637 16/93 (17%)
Cadherin_repeat 2627..2725 CDD:206637 18/83 (22%)
Cadherin_repeat 2742..2848 CDD:206637
Cadherin_repeat 2857..2958 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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