DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Cdh12

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001008420.1	Gene:	Cdh12 / 215654	MGIID:	109503	Length:	794	Species:	Mus musculus

Alignment Length:	546	Identity:	170/546 - (31%)
Similarity:	278/546 - (50%)	Gaps:	57/546 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1548 DKDRPQNIV-YFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQD-EG 1610
            |.|:.:..| |.|:|.|      |.:.|.|:.|||:|..::.|||::   :|.:.....|.| |.
Mouse    81 DLDKGEGTVKYTLSGDG------AGTVFTIDETTGDIHAIRSLDREE---KPFYTLRAQAVDIET 136

  Fly  1611 GEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYS 1675
            .:.|...::..:.::|||||.|.|..|.|..:|.|....|..|:.:.|.|.|||..|::||:|||
Mouse   137 RKPLEPESEFIIKVQDINDNEPKFLDGPYVASVPEMSPVGAYVLQVKATDADDPTYGNSARVVYS 201

  Fly  1676 IEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDG----GGLKGTGTASIRV 1736
            |.:       |.|.|.|:|.||||:||:..:|||....|.:.:.|.|.    |||.||...:|.:
Mouse   202 ILQ-------GQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTVVNITL 259

  Fly  1737 KDINDMPPQFTKDEWFTEVDETD--GTALPEMPILTVTVHDED--ETNKFQYKVIDNSGYGADKF 1797
            .|:||.||:|.|..:..:|.|:.  |:|:..     :...|.|  :..:.:|.::  .|.|.:.|
Mouse   260 TDVNDNPPRFPKSIFHLKVPESSPVGSAIGR-----IRAVDPDFGKNAEIEYNIV--PGDGGNLF 317

  Fly  1798 TMVRNND-GTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVA-----YSWVVVKLR 1856
            .:|.:.| ..|.:|:.:|||:|.:   ..:.|:::.::...|:   ::|.|     .:.|.:.:.
Mouse   318 DIVTDEDTQEGIIKLKKPLDFETK---KAYTFKVEASNLHLDH---RFHSAGPFKDTATVKISVL 376

  Fly  1857 DINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAIN-QNG 1920
            |: |..|.|.:....:.|:|||.|||.:....|.|.|. |.|.|.|.||..||.:..|.|: ..|
Mouse   377 DV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDV-GSSAVRYFIDWKSDGESYFTIDGTEG 439

  Fly  1921 SVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPR 1985
            ::.....||||.:.::...|:|....:|..|:...:.:.|.|:|:..|:....|...:.|:..|.
Mouse   440 TIATNELLDRENMAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPG 504

  Fly  1986 KVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRS-FDREQ 2049
            ::::|:...|.|.|.: |..|.|||.|.|  :|:.:|.|...:....|     |.:.|: :.|.|
Mouse   505 QIIQIVGAVDRDLSPA-GQQFSFRLAPEA--VIKPNFTVHDFRNNTAG-----IETRRNGYSRRQ 561

  Fly  2050 QKEYMIPIVIKDHGSPAMTGTSTLTV 2075
            |:.|.:||||:|...|..:.|:|:|:
Mouse   562 QELYFLPIVIEDSSYPVQSSTNTMTI 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	25/83 (30%)
		Cadherin_repeat	1638..1741	CDD:206637	41/106 (39%)
		Cadherin_repeat	1762..1861	CDD:206637	21/106 (20%)
		Cadherin_repeat	1871..1966	CDD:206637	32/95 (34%)
		Cadherin_repeat	1974..2083	CDD:206637	33/103 (32%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Cdh12	NP_001008420.1	CA	80..158	CDD:214520	27/85 (32%)
		Cadherin_repeat	164..265	CDD:206637	42/107 (39%)
		Cadherin_repeat	273..380	CDD:206637	24/120 (20%)
		Cadherin_repeat	389..484	CDD:206637	31/95 (33%)
		Cadherin_repeat	492..590	CDD:206637	33/104 (32%)
		Cadherin_C	638..785	CDD:395833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910