DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN and CELSR2

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_001399.1 Gene:CELSR2 / 1952 HGNCID:3231 Length:2923 Species:Homo sapiens


Alignment Length:2084 Identity:520/2084 - (24%)
Similarity:805/2084 - (38%) Gaps:537/2084 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   966 PVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKGTK-FTVDEETGEVS 1029
            |.|:..| |...|.|..|.|:||..:.|.|.|:|..|:::|::....:.:..: |::|..||.|:
Human   179 PQFQPPS-YQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVT 242

  Fly  1030 TNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFDRQKYVENVKQDASIG 1094
            |.:..|||........||  |.|.|.|....:.:.|:.:||.||:.|:|::|:|.|:::::..:|
Human   243 TAEELDRETKSTHVFRVT--AQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVG 305

  Fly  1095 TNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVLKKPLDGCYPRDR---YRLR 1156
            ..:|.|.|:|.||..|..|:|.|......:..|.|||...||.|..:.|:|    |:.   |:|.
Human   306 YEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD----REEVESYQLT 366

  Fly  1157 VSASDKGT---PASAADVDVELDVVDRNNKPPIWDKSIYGPIHIRENVTVGTVVTSVKASSGIEG 1218
            |.|||:|.   |.|.. ..|.|.|.|.|:..|.:.:..| .:.:||:||.|..|..|.||...:|
Human   367 VEASDQGRDPGPRSTT-AAVFLSVEDDNDNAPQFSEKRY-VVQVREDVTPGAPVLRVTASDRDKG 429

  Fly  1219 -NPTVFYRLMPGSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEYNLTIRVENNGAQQ 1282
             |..|.|.:|.|     |....|||     :..|.| :.|..|||||:.|||.|.:|.::.|...
Human   430 SNAVVHYSIMSG-----NARGQFYL-----DAQTGA-LDVVSPLDYETTKEYTLRVRAQDGGRPP 483

  Fly  1283 LAS-EATVYIMLEDVNDEIPLFTERE-QETVLEGEPIGTKVTQVNAIDKDGTFPNNQVYYYIVDS 1345
            |:: ...|.:.:.|:||..|:|.... |.||||..|:|..|..|.|||.|.. .|.::.|.:.  
Human   484 LSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG-DNARLEYRLA-- 545

  Fly  1346 PRNEGKEF-FEINLQSGEIFTKTVFDREKKGAYALEVEARD-GAPSARPNSNGPNSVTKFIRIGI 1408
              ..|.:| |.||..:|.|......|||:...|:..||||| |.|:...:::        :.:.:
Human   546 --GVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASAS--------VSVTV 600

  Fly  1409 ADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGA- 1472
            .|.|||.|.|.:..|...::|:..:..:|:||:|.|.|..|.|.|:|||||....|::.:.:|. 
Human   601 LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGG 665

  Fly  1473 -IYVAGALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTYRTQITEEDDRNLP 1536
             :.:|..|||:..|:|.|.:.|||..:::...::::|.|.|.:.|||:...|...:.|       
Human   666 LVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNE------- 723

  Fly  1537 KRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWR 1601
                         |||                                                 
Human   724 -------------DRP------------------------------------------------- 726

  Fly  1602 FTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNE 1666
                                                           ||..|:.::|.|.|   .
Human   727 -----------------------------------------------AGTTVVLISATDED---T 741

  Fly  1667 GSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGT 1731
            |.|||:.|.:|.::       |.|.|:.|||.:.|..                            
Human   742 GENARITYFMEDSI-------PQFRIDADTGAVTTQA---------------------------- 771

  Fly  1732 ASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGADK 1796
                                                                             
Human   772 ----------------------------------------------------------------- 771

  Fly  1797 FTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDN 1861
                             .||||||:   .:...|...|.|....:|.     :::.:.:.|:|||
Human   772 -----------------ELDYEDQV---SYTLAITARDNGIPQKSDT-----TYLEILVNDVNDN 811

  Fly  1862 KPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAI-NQNGSVTIQ 1925
            .|.|.|.:.:.||:||....|.:.:..|||.|.|...:|.|:.....|....|.: :.:|.|...
Human   812 APQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL 876

  Fly  1926 RSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPP--RKVV 1988
            |.||||.|.::.::..|:|.|.||......:||.|.|:|||.|.|.:|...|..|...|  ..|.
Human   877 RRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA 941

  Fly  1989 EILATDDDDRSKS--------NGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSF 2045
            .:.|||.|:.:.:        ...|..|:||..:.:                      :::|...
Human   942 RVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE----------------------LTALVDL 984

  Fly  2046 DREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNY----QGQSPDTPI 2106
            |.|.:.||:  :||:...:| :...:|:.|.:.|.|||....|:.:|...||    ....|...|
Human   985 DYEDRPEYV--LVIQATSAP-LVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAI 1046

  Fly  2107 GRVYVYDLDDWDLPDKKFYWEAMEHPRFKLDEDSGMVTMRAGTREGRYHLRFKVYDRKHTQTDIP 2171
            |||..:|.   |:.|...|       .|:...:..:|.:.|.|.|      .|:.........:.
Human  1047 GRVPAHDP---DISDSLTY-------SFERGNELSLVLLNASTGE------LKLSRALDNNRPLE 1095

  Fly  2172 ANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSRSK-----MDRFRDKLADLLNT 2231
            |.::|.|.:..| :|....::|::.|:||........|.:.||..:     :..|...:|..|.|
Human  1096 AIMSVLVSDGVH-SVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLAT 1159

  Fly  2232 ERENVDIFSVQLKRKHP--PLTDVRFSAHGSPYYKPVRLNGIVLMHREEIEKDVGIN---ITMVG 2291
            ..::|.:|:||.....|  .:.:|..|. |.|   |....|...:..|::::.:.:|   :|.:.
Human  1160 PPDHVVVFNVQRDTDAPGGHILNVSLSV-GQP---PGPGGGPPFLPSEDLQERLYLNRSLLTAIS 1220

  Fly  2292 IDECL-YENQMC-EGSCTNSLEI-------SPLPYMVNAN----------------KTALVGVRV 2331
            ....| :::.:| ...|.|.:..       |..|::.:::                .....|...
Human  1221 AQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYC 1285

  Fly  2332 DTIAD------------C-------TCGARNFTKPESC-------RTTP--CHNGGRCVDTRFGP 2368
            :|..|            |       ||..|:....|.|       |.||  |.|||.||:...|.
Human  1286 ETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGG 1350

  Fly  2369 -HCSCPVG-YTGPRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYNGPIVPPER 2431
             .|.||.| :..|.||.|||||..:.:..:..|.......|:|.|.|::.|||::|||...... 
Human  1351 FKCDCPSGDFEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKH- 1414

  Fly  2432 DETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFW-------------- 2482
                  ||:|||:.:...:|....|..|..:.......:.||:||.:.|.:              
Human  1415 ------DFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQG 1473

  Fly  2483 -DTESIRMV-VDFCKSAEIAEMEDGTPPEFDDM----SCQARGQIPPFNEYLNVNAPLQVGGL-- 2539
             ..:.:.:| ||.|        :.|....|..:    ||.|:|......:.|::..||.:||:  
Human  1474 PSEQKVAVVTVDGC--------DTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPD 1530

  Fly  2540 YREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCAQTETTAR 2604
            ..|.|...:         :.|.||:|||..:|:..|:|....:..:|.|||..:.||    .:..
Human  1531 LPESFPVRM---------RQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVC----DSNT 1582

  Fly  2605 CWEHGNCVGSLSEARCHCRPGWTGPAC-----NIPTIPTTFKAQSYVK-YALSFEPDRFSTQVQL 2663
            |...|.||.......|.|..|:.|.:|     |    |..|...|.|. :.||. |......:.|
Human  1583 CHNGGTCVNQWDAFSCECPLGFGGKSCAQEMAN----PQHFLGSSLVAWHGLSL-PISQPWYLSL 1642

  Fly  2664 RFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVVKV 2728
            .||||:..|.|.:...: .|....|::::||:  ..::.....:...|.|.....|||.||..::
Human  1643 MFRTRQADGVLLQAITR-GRSTITLQLREGHV--MLSVEGTGLQASSLRLEPGRANDGDWHHAQL 1704

  Fly  2729 NRYGSA----ATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVY------------AGGKAEYTG 2777
            ....|.    |.|..|.|:.|....          |..:..|::            |||.|    
Human  1705 ALGASGGPGHAILSFDYGQQRAEGN----------LGPRLHGLHLSNITVGGIPGPAGGVA---- 1755

  Fly  2778 VRTFEVYADYQKSCLDDIRLEGKHLPLPPAMNG--TQWGQATMARNLEKGCPSNKPCSNVICPDP 2840
             |.|       :.||..:|:.    ..|..:|.  ...|::.   |:|:||....||.:..||..
Human  1756 -RGF-------RGCLQGVRVS----DTPEGVNSLDPSHGESI---NVEQGCSLPDPCDSNPCPAN 1805

  Fly  2841 FECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPCMNGATCINLEPRL--RYRCICPDGFWG 2903
            ..|.:.|:.|.|:|      .|...|....|.|...||.:.:.|.. :|..  .|.|.||..:.|
Human  1806 SYCSNDWDSYSCSC------DPGYYGDNCTNVCDLNPCEHQSVCTR-KPSAPHGYTCECPPNYLG 1863

  Fly  2904 ENCE 2907
            ..||
Human  1864 PYCE 1867

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637 32/101 (32%)
Cadherin_repeat 1083..1166 CDD:206637 30/88 (34%)
Cadherin_repeat <1219..1298 CDD:206637 26/79 (33%)
Cadherin_repeat 1310..1414 CDD:206637 34/105 (32%)
Cadherin_repeat 1423..1514 CDD:206637 31/92 (34%)
Cadherin_repeat 1522..1630 CDD:206637 5/107 (5%)
Cadherin_repeat 1638..1741 CDD:206637 19/102 (19%)
Cadherin_repeat 1762..1861 CDD:206637 12/98 (12%)
Cadherin_repeat 1871..1966 CDD:206637 32/95 (34%)
Cadherin_repeat 1974..2083 CDD:206637 24/118 (20%)
EGF 2350..2380 CDD:278437 15/40 (38%)
LamG 2385..2570 CDD:238058 51/206 (25%)
EGF_2 <2605..2631 CDD:285248 8/25 (32%)
Laminin_G_2 2665..2800 CDD:280389 34/150 (23%)
EGF_CA 2869..2907 CDD:238011 11/39 (28%)
Cadherin_C 2952..3088 CDD:279398
CELSR2NP_001399.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..198 7/19 (37%)
Cadherin_repeat 185..285 CDD:206637 33/102 (32%)
Cadherin_repeat 293..395 CDD:206637 37/106 (35%)
Cadherin_repeat 404..501 CDD:206637 38/108 (35%)
Cadherin_repeat 509..606 CDD:206637 35/109 (32%)
Cadherin_repeat 614..708 CDD:206637 31/93 (33%)
Cadherin_repeat 716..811 CDD:206637 36/338 (11%)
Cadherin_repeat 819..917 CDD:206637 32/97 (33%)
Cadherin_repeat 925..1019 CDD:206637 24/118 (20%)
Cadherin_repeat 1042..1120 CDD:206637 21/94 (22%)
EGF_CA 1289..1324 CDD:238011 6/34 (18%)
EGF_CA 1333..1366 CDD:238011 14/32 (44%)
LamG 1369..1552 CDD:238058 51/206 (25%)
EGF_CA 1578..1609 CDD:238011 9/34 (26%)
LamG 1618..1767 CDD:238058 40/174 (23%)
EGF_CA 1795..1829 CDD:238011 11/39 (28%)
EGF 1832..1865 CDD:278437 10/33 (30%)
EGF_Lam 1924..1969 CDD:214543
HormR 1972..2034 CDD:214468
GAIN 2052..2287 CDD:293098
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2213..2238
GPS 2315..2368 CDD:197639
7tm_4 2402..2605 CDD:304433
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2688..2838
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2854..2888
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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