DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN and cdh-1

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_497641.2 Gene:cdh-1 / 187783 WormBaseID:WBGene00019994 Length:2779 Species:Caenorhabditis elegans


Alignment Length:2436 Identity:566/2436 - (23%)
Similarity:932/2436 - (38%) Gaps:535/2436 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 INGSSHSGAAAYHML---DTDYSKYFTVLE-DGVVMTTADISPLVNRPVQLVVVEQTPNATNTHN 156
            |:|.....||..:.:   |...||:..|.| .|.:.|.|.:.........:|.| :...:..|.:
 Worm    44 ISGKREESAAPKYFVVFPDEQTSKFLKVDERSGEISTIAHLDYEKRSKFDIVAV-KVEESGETID 107

  Fly   157 LQLFVMHRNDML-RFSGSLLDASGEVRENQPAGTRVRGVPLMQAFSGSILDEELATPKKVRYTII 220
            :.:.|...||.. .|:..::..  |:.|....||.. .:|.:....|...|..       |:.|:
 Worm   108 ILVEVDDENDNAPSFADQVVKL--EISEFAQLGTSF-ALPTVTDGDGPKFDVH-------RFVIL 162

  Fly   221 DGNVDDAFALQERKANKNIQISAKSLVINGDDESGVWLVTNRPLDREERAHYDLSVEASDVDGLD 285
            .|||::.|.|..||.|:.:|   ..||:||.            ||||.|..|:|.:||.| .|..
 Worm   163 QGNVNNVFKLASRKVNEQLQ---ADLVVNGQ------------LDREFRDKYELLIEAQD-GGKP 211

  Fly   286 RTVSKIQ--ITVLDENDNRPIFKSLDYKFAIAGQKSASMESNSSVTYQRFAIMGKVEATDAD--- 345
            ..:.:::  |.::|.|||.|:|....|        :||:.:|.|:......    |:|||||   
 Worm   212 AKIGQLRCSIEIIDANDNAPVFSRSRY--------TASVSANISIGSHLIT----VQATDADIGE 264

  Fly   346 GDKIAYRLK---SPSNVVIIVPQTGEIMLAGE--PTSNELLIEVIAHDLRYPSLVSAK--PAKVL 403
            ..:|:|.:|   :|||....:.|:|.|.....  |.|...:| |:|.|...|||.|:.  ...||
 Worm   265 NSRISYDIKKTSAPSNSNFAISQSGVITTTASLLPASTHDVI-VVASDHGSPSLSSSAVVTITVL 328

  Fly   404 LEFLAAEPVSFIMQHLEHDDINNHSHHREKRRVTRAVRPTKRIEFTEADGDTE----GKSVFQLE 464
            ...|::.|:..|..      :.::|.|..:.....::  ..|:...:...||:    |.|.    
 Worm   329 GSTLSSPPLDIIWL------VESNSAHLMENSTLGSI--VARVSIAQQYRDTKLRLIGSSA---- 381

  Fly   465 KETDKETFKIRDDNPWVTVETNGAVRVKKKWDYEELGPEKTIDFWVII----------TNMGHNA 519
                                               |.|::|....|.:          |...|: 
 Worm   382 -----------------------------------LCPQQTDQAHVYLLLLCGILDRETASEHH- 410

  Fly   520 GIKY---TDNQRVI-----ILVKDVNDEPPYFINRPLPMQAVVQLNAPPNTPVFTLQARDPDTDH 576
             :|:   .|.|.:|     :.:.|:||..|.:.:    .|..:.||...... .||.|:|||...
 Worm   411 -LKFLLEKDGQIIIEHPQLLTIGDINDNAPQWHS----SQIHISLNRTQGGS-RTLTAKDPDLGQ 469

  Fly   577 N--IHYFIVRDRTGGRFEVDERSGVVRTRGTDLFQLDMEYVLYVKAEDQNGKVDDRRFQSTPEER 639
            |  |.|.::....   ..:|:.:|.:....|....:..|....|:|||.....     .||.   
 Worm   470 NGWIRYSVLDTEL---VSIDKETGRIFVPNTIDCNIGSEIKFRVRAEDGGSPA-----LSTD--- 523

  Fly   640 LSIVGG-----KRAPQFYMPSYEAEIPENQKKDSDIISIKAKSFA---DREIRYTLKAQGQGAGT 696
            |.:|..     .:.|||....::.||||:....:.::.:.|.:..   .:.|||:|:.|.:   .
 Worm   524 LQVVADLLDTESKPPQFEKALWQVEIPEDTPIGTCLVKVVANNSQCGNSKRIRYSLQNQDE---H 585

  Fly   697 FNIGPTSGIVKLAKELDFEDLRQPHVYSLIVTATEDSGGFSTSVDLTIRVTDVNDNAPKFELPDY 761
            ..:...||.|.:.|..|||..:.   |...|.||..:...|||: ::||:.|||||.|.|...:|
 Worm   586 LTVDTMSGTVCIQKTFDFEKQKS---YQTTVIATNANSETSTSL-ISIRLKDVNDNWPIFYPNEY 646

  Fly   762 QAHNVDEDIPLGTSILRVKAMDSDSGSNAEIEY--LVSDDHFAVDS-NGIIVNNKQLDADNNNAY 823
            .. .|.|.......:|.|.|.|.|||:..|:.|  |.....|:::. .|.:...|.|    ....
 Worm   647 HL-TVREGPKPEEPLLVVSASDMDSGTFGEVSYHILSESSSFSINPVTGEVFAQKPL----ARGR 706

  Fly   824 YEFIVTAKDKGEPPKSGVATVRVYTKNKNDEEPKFSQQVYTPNVDENAGPNTLVTTVVASDKDGD 888
            :..:|:|||.|.......|.:.:...:|:.:.|:||:..|.....|:..|...:.:|.|..|   
 Worm   707 FHLVVSAKDGGGQSSENSANIHITVIDKDTKTPQFSRSKYEIRTTEDILPGIAIGSVGAMSK--- 768

  Fly   889 NVRFGFVGGGTSSGQFVIEDITGVIRLHNKAISLDKDKYE---LNVTA-MDDGSCCVNGDQTIHT 949
             |::. :..|.....|.|::.||.|.:..   .||.|.::   ||:.| :..|    ..:||   
 Worm   769 -VKYS-IYSGDQDHNFSIDEDTGKIYVTR---YLDADVHDTVLLNIQATLPSG----ESNQT--- 821

  Fly   950 STAVVVVFITDVNDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQ 1014
               .||:||.|.|||.|.|.. |.....:.|......|...|.|:|:||..||:|:|||:.  :.
 Worm   822 ---QVVIFIEDHNDNPPQFSS-SLVEISIREDLKLHEPFYVVQASDKDKKKNGEVRYSIIS--SH 880

  Fly  1015 KGTKFTVDEETGEVSTNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFD 1079
            .|:...:|:.||::||..:.|.|..  :...:.|||||.|.|......:..:.:.|||||.|.|:
 Worm   881 PGSSIEIDQFTGQLSTGSLLDYEAT--RNYKLRVKATDLGIPPRSSNMTLFIHVLDVNDNAPEFE 943

  Fly  1080 RQKYVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVLKKPL 1144
            :..|...|.:::...|.:.:|.|.|:|:..||.|||.:|     |..|||.|..:.|.:..|:.:
 Worm   944 KSWYTMEVLENSPPKTIVGKVVARDKDSLENGQIVYRIT-----NGSEYFGIDEKLGNVYTKRSI 1003

  Fly  1145 DGCYPRD---RYRLRVSASDKGTPASAADVDVELDVVDRNNKPP--IWDKSIYGPIHIRENVTVG 1204
            |    |:   ...:.:.|.|||.|..::.....:.|:|.|:.||  :....|..|.....:..:|
 Worm  1004 D----REVISHVDISIVAEDKGVPPRSSTASARISVLDVNDNPPSCLSITPIVVPAGSPLSTAIG 1064

  Fly  1205 TVVTSVKASSGIEGNPTVFYRLMPGSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEY 1269
            |:| ::....|:.|  :|.||....|:....|          .|||.:    :...|:....:..
 Worm  1065 TIV-AMDPDKGLNG--SVLYRAQLQSSLFVVK----------SNGDVY----LRRQLNASDERHQ 1112

  Fly  1270 NLTIRVENNGAQQLASEATVYIMLE----DVNDEIPLFTEREQETVLEGEPIGTKVTQVNAID-- 1328
            .|::.|.:.|..:.:....|.:.:.    |:..:.|.   ::...:.:..|.|.::|.:||..  
 Worm  1113 RLSVIVSDQGVPRKSVVCHVPVRISKGSADIQIQEPF---QKYIEIPKSCPTGCRLTTLNATGVS 1174

  Fly  1329 ---------------KDG-----TFPNNQVYY--YIVDSPRNEGKEFFEIN-LQSGEIFTK---- 1366
                           ::|     :.|.::..|  .||.|.:|:.::..::. |.|||...|    
 Worm  1175 SWLIQSSEISNHFAIREGVLFMISHPIHRPPYSLVIVLSDKNDRQKSIQLRVLASGEAANKEETI 1239

  Fly  1367 -------------TVFDREKKGAYALEVEARDGAPSARPNSNGPNSVTKFIRIG----------- 1407
                         .:.::...|::.....:.:..|.....:.|...:...:|.|           
 Worm  1240 RISDSNSIGTKIGRLGEKSADGSFFYRFSSEESCPLELDQTGGLLYLADGLRRGDTHNFSCFFEK 1304

  Fly  1408 ----------------IADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESS---RIRY 1453
                            |:....:.|.||.......:.|:......:.||.|...|:|:   ..|:
 Worm  1305 FNTTDGSAEEMRVDLEISRTKSDKPRFDTGHLRVNIREDTPTGSIITTVNATVSDDSASPISYRF 1369

  Fly  1454 EITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPP-V 1517
            .:...|    |::...||.|.:...|.:.....|.|.:.|..:.......|.::|.||||:.| :
 Worm  1370 PLLIDN----FSIDQFTGDITLIDTLHWHVTPTYNLIVEAFTSGPGTTLLVTVNVDDVNDHTPFI 1430

  Fly  1518 FERPTYRTQITEEDDRNLPK------RVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDI 1576
            ..:||..          ||.      .|.:|.|.|.||| |: |.|.|...|   ...|...|.|
 Worm  1431 VSQPTVL----------LPSSYRKGGMVHRVVAIDLDKD-PE-IRYSLKYAG---SEVAKEFFKI 1480

  Fly  1577 NRTTGEIFVL-----------------------------------KPLDRDQPNGRPQWRF---- 1602
            :..:|||||:                                   |.|.:.....|..|.|    
 Worm  1481 DEKSGEIFVVESSSALSTSFGGAGLPETLTIRATDLQDLTKFDEQKVLLKASNASRSTWHFFDEQ 1545

  Fly  1603 ----TVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYF----GNVTENGTA---GMVVMTM 1656
                |:.:....|..:     :|:..::..| ..:.|...:|    ..:.:...:   |....|:
 Worm  1546 HKDVTILSTSPQGSQI-----LQLKFQEGVD-LQLIPSSPHFELKSSKIVQKSASVATGTQRFTI 1604

  Fly  1657 TA-----VDY------------DDPNEGSNARLVYSIEKNV-IEE-----ETG------------ 1686
            .|     :||            :.|...|.:..|.:||:|| ||:     .||            
 Worm  1605 VAQKDDELDYSTLKIHVEPVFTEPPKISSTSCGVVTIEENVGIEDFKRILATGMTEESRFRFQGN 1669

  Fly  1687 SPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVKDINDMPPQF---TK 1748
            :|.|.|...||.|  :|..||||.:.::.:.::..|||....:.|..:.|.|.||..||.   |.
 Worm  1670 APKFSINSTTGSI--SVLPLDREASQEHLLIIILTDGGSRNDSCTVRVTVADQNDNKPQLDASTP 1732

  Fly  1749 DEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGADKFTMVRNNDGTGSLKIVQ 1813
            .|  .|:.|:....              |..::|:...:|....|  ||:.....|.:|||.:|.
 Worm  1733 SE--LEIAESSRVG--------------DVLHRFRASDMDIGQNG--KFSFELLEDSSGSLDLVP 1779

  Fly  1814 P-----LDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEVS 1873
            .     |.....|||  ::.:::|.|          |......|.|..:|::..|..| |...:.
 Worm  1780 ETGDLVLRRLSSLQS--WKIKLRVVD----------HGVPGLYVEKNLEISNRNPQTE-AKAPLE 1831

  Fly  1874 VFEDTKVGTELE-----KFKA-TDPDQGGKSKVSYSIDRSSDRQRQFAINQNGSVTIQRSLDREV 1932
            ..:.|.:.|..|     :|.| ..|:..|   ::||| ...:....|:::..|.:.....||||:
 Worm  1832 FLKQTYLSTIDEGLPRGQFIAKLQPELAG---LTYSI-VEGNIDSAFSVDSEGVIRTNLELDREI 1892

  Fly  1933 VPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEILATDDDD 1997
            :.|:.:|::....|....|   .:.|.|.::|||.|.|.......:||::.....|..:...|.|
 Worm  1893 LERYSLKVIGTGSGQQIGT---RVDVRVNNLNDNVPSFPMSKPRRVPENLRVGSYVATVGAKDVD 1954

  Fly  1998 RSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKDH 2062
                |..|.::.|...:.......|.::|        ....|......|.|...|:.:.|...|.
 Worm  1955 ----NLAPLRYFLVSDSSGQTPTHFNIDQ--------FTGTIHLTAPLDFEVLPEHTLTIKATDG 2007

  Fly  2063 GSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQ------SPDTPIGRVYVYDLD-----D 2116
            .....|   .||:.:.|:||| ....||.:    ||..      ||..|..::..:|||     .
 Worm  2008 SFDTFT---NLTIFVSDINDN-APTFSKPL----YQTTVSPATFSPGQPFAKIEAHDLDARGALT 2064

  Fly  2117 WDLPDKKFYWEAMEHPRFKLDEDSGMVTMRAGTREG-RYHLRFKVYDR--KHTQTDIPANVTV-- 2176
            :.|...       ....|::..:||.:.|:.....| ||.:.....|.  ....|.:|.:|.:  
 Worm  2065 YSLGQG-------SSSIFRVAPESGALFMKVLPPAGERYLVTVTATDNGVPSFSTSVPVSVIIGE 2122

  Fly  2177 ---------TVREIPHEAVVNSG-SVRLSGISDEDFIRVWNYRTQSMSRSK---MDRF-RDKLAD 2227
                     ...|...|.:.||. .:::..:|.|: .|.::||.|....||   :|:| |..:|.
 Worm  2123 AEPTDKPGFEKAEFRFEVMENSKIGLQIGNLSGEE-SREFHYRIQDPEASKIFSIDKFGRLFVAG 2186

  Fly  2228 LLNTERENVDIFSVQLKRKHPPLTDVRFSAH 2258
            .::.|:.....|.|::..:......|:...|
 Worm  2187 PIDREQRATHEFQVEIDNEMMTSQKVQCKCH 2217

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637 36/124 (29%)
Cadherin_repeat 337..396 CDD:206637 24/66 (36%)
E_set 449..541 CDD:298831 17/113 (15%)
Cadherin_repeat 549..>625 CDD:206637 20/77 (26%)
Cadherin_repeat 655..752 CDD:206637 29/99 (29%)
Cadherin_repeat 765..853 CDD:206637 23/90 (26%)
Cadherin_repeat 862..964 CDD:206637 28/105 (27%)
Cadherin_repeat 973..1074 CDD:206637 31/100 (31%)
Cadherin_repeat 1083..1166 CDD:206637 26/85 (31%)
Cadherin_repeat <1219..1298 CDD:206637 14/82 (17%)
Cadherin_repeat 1310..1414 CDD:206637 23/172 (13%)
Cadherin_repeat 1423..1514 CDD:206637 21/93 (23%)
Cadherin_repeat 1522..1630 CDD:206637 31/156 (20%)
Cadherin_repeat 1638..1741 CDD:206637 34/144 (24%)
Cadherin_repeat 1762..1861 CDD:206637 21/103 (20%)
Cadherin_repeat 1871..1966 CDD:206637 23/100 (23%)
Cadherin_repeat 1974..2083 CDD:206637 21/108 (19%)
EGF 2350..2380 CDD:278437
LamG 2385..2570 CDD:238058
EGF_2 <2605..2631 CDD:285248
Laminin_G_2 2665..2800 CDD:280389
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
cdh-1NP_497641.2 Cadherin_repeat 29..118 CDD:206637 17/74 (23%)
Cadherin_repeat 129..229 CDD:206637 36/125 (29%)
Cadherin_repeat 238..328 CDD:206637 30/102 (29%)
Cadherin_repeat 459..532 CDD:206637 21/83 (25%)
Cadherin_repeat 546..637 CDD:206637 29/97 (30%)
Cadherin_repeat 645..733 CDD:206637 23/92 (25%)
Cadherin_repeat 746..833 CDD:206637 28/104 (27%)
Cadherin_repeat 843..938 CDD:206637 31/98 (32%)
Cadherin_repeat 947..1041 CDD:206637 30/102 (29%)
Cadherin_repeat 1051..1136 CDD:206637 20/101 (20%)
Cadherin_repeat 1337..1426 CDD:206637 21/92 (23%)
Cadherin_repeat 1445..>1515 CDD:206637 20/74 (27%)
Cadherin_repeat 1638..1723 CDD:206637 27/86 (31%)
Cadherin_repeat 1734..1817 CDD:206637 23/112 (21%)
Cadherin_repeat 1836..1923 CDD:206637 23/93 (25%)
Cadherin_repeat 1934..2025 CDD:206637 21/105 (20%)
Cadherin_repeat 2034..2120 CDD:206637 20/92 (22%)
Cadherin_repeat 2135..2226 CDD:206637 21/84 (25%)
Cadherin_repeat 2235..2330 CDD:206637
Cadherin_repeat 2345..2437 CDD:206637
Cadherin_repeat 2446..2534 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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