Protein Alignment CadN and DSG2

DIOPT Version :10

• Sequence 1: NP_001027277.1
• Gene: CadN / 35070
• FlyBaseID: FBgn0015609
• Length: 3101
• Species: Drosophila melanogaster
• Sequence 2: NP_001934.2
• Gene: DSG2 / 1829
• HGNCID: 3049
• Length: 1118
• Species: Homo sapiens
• Alignment Length: 910
• Identity: 205/910 - (22%)
• Similarity: 344/910 - (37%)
• Gaps: 251/910 - (27%)

  Fly  1512 NDNPPVFERP----------TYRTQITEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDP 1566
            |:|..:.:.|          |....:.|.:|.:....:.:: .:|..::|...|.|..||:||
Human    33 NENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKI-HSDLAEERGLKITYKYTGKGI-- 94

  Fly  1567 DNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNA 1631
            ..|....|..|:.|||:.|...|||::   .|.:..|.:|.|..|..:....::::.:.|||||.
Human    95 TEPPFGIFVFNKDTGELNVTSILDREE---TPFFLLTGYALDARGNNVEKPLELRIKVLDINDNE 156

  Fly  1632 PIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDT 1696
            |:|.|.|:.|:|.|...|..:||.:.|.|.|:||. .|:::.|.|   |..|....|:|.:..||
Human   157 PVFTQDVFVGSVEELSAAHTLVMKINATDADEPNT-LNSKISYRI---VSLEPAYPPVFYLNKDT 217

  Fly  1697 GVIKTAVCCLDRERTPDYSIQVVAMDGGG------LKGTGTASIRVKDINDMPPQFTKDEWFTEV 1755
            |.|.|....||||....|::.|.|.||.|      :| .....||:.|:||..|
Human   218 GEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVK-QAQVQIRILDVNDNIP----------- 270

  Fly  1756 DETDGTALPEMPILTVTVHDEDETN--KFQYKVIDNSGYGAD----KFTMVRNNDG--------- 1805
                   :.|..:|...| :|::.|  ..:.||.|....|:|    .||....|:|
Human   271 -------VVENKVLEGMV-EENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDA 327

  Fly  1806 ---TGSLKIVQPLDYEDQLQSNGFRFRIQVNDKG--EDNDNDKYHVAYSWVVVKLRDINDNKPHF 1865
               .|.:.:::.:|||:.   ....|.:.|.:|.  ..:...||......:.||::::.:. .||
Human   328 QTNEGIVTLIKEVDYEEM---KNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEG-IHF 388

  Fly  1866 ERANVEVSVFED---TKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAIN---------- 1917
            :.:.:.:.|.|.   :..|..:..|:|.|.|.|..:...|.  :..||....:::
Human   389 KSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYV--KLEDRDNWISVDSVTSEIKLAK 451

  Fly  1918 ---------QNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKD 1973
                     |||:.|              |||:||.:..|.||.|.|:.:.|:|||||.|..::.
Human   452 LPDFESRYVQNGTYT--------------VKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEP 502

  Fly  1974 YRPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRL---DPSADD---IIR---ASFKVEQDQK 2029
            .:.:..:    .:.|.:.|.|.|  ...|..||.|.:   .|...:   |.|   .|..::|.:|
Human   503 VQTICHD----AEYVNVTAEDLD--GHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEK 561

  Fly  2030 G-ANGDGMAVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIF 2093
            . ...:...:||..:.|...:::...:.:....|||..........|.:|        |.:..:.
Human   562 KLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLG--------PAAIALM 618

  Fly  2094 VYNY----------------QGQSPDTPI-GRVYVYDLDDWD----LPDKKFYWEAMEHPRF-KL 2136
            :..:                :|....||| |.:.:  |..|:    .|:.|..      |.| .:
Human   619 ILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEM--LHPWNNEGAPPEDKVV------PSFLPV 675

  Fly  2137 DEDSGMV------------TMRAGT-------------REGRYHLRFKVYDRKHTQ--------- 2167
            |:...:|            ||:..:             .:||:.....:...:.||
Human   676 DQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIM 740

  Fly  2168 ---TDIPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNY--------------------- 2208
               |...|..|...|::   |...:.:|.|    :|:|:|  ||
Human   741 TTETTKTARATGASRDM---AGAQAAAVAL----NEEFLR--NYFTDKAASYTEEDENHTAKDCL 796

  Fly  2209 ------RTQSMSRS----------KMDRFRDKLADLLNTERE-----NVDIFSVQLKRKHPPLTD 2252
                  .|:|::.|          ..|||.|.|.....|..|     .:|| :.:::::..|.|:
Human   797 LVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDI-NKEIEQRQKPATE 860

  Fly  2253  2252
            Human   861  860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		CA_like	449..541	CDD:481204
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637	1/1 (100%)
		Cadherin_repeat	1522..1630	CDD:206637	29/107 (27%)
		Cadherin_repeat	1638..1741	CDD:206637	38/108 (35%)
		CA	1770..1863	CDD:214520	23/112 (21%)
		Cadherin_repeat	1871..1966	CDD:206637	29/116 (25%)
		Cadherin_repeat	1974..2083	CDD:206637	22/118 (19%)
		EGF	2350..2380	CDD:394967
		LamG	2385..2570	CDD:238058
		EGF_2	2605..2631	CDD:400365
		LamG	2637..2797	CDD:238058
		EGF_CA	2869..2907	CDD:238011
		CADH_Y-type_LIR	3029..3088	CDD:460041
DSG2	NP_001934.2	Cadherin_repeat	62..155	CDD:206637	27/98 (28%)
		Cadherin_repeat	163..268	CDD:206637	39/109 (36%)
		CA_like	281..377	CDD:481204	21/99 (21%)
		Cadherin_repeat	392..495	CDD:206637	29/118 (25%)
		Desmoglein repeat 1	881..912
		Desmoglein repeat 2	913..942
		Desmoglein repeat 3	943..968
		Desmoglein repeat 4	969..992
		Desmoglein repeat 5	993..1021
		Desmoglein repeat 6	1022..1051
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1068..1118