DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and DSC2

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_077740.1	Gene:	DSC2 / 1824	HGNCID:	3036	Length:	901	Species:	Homo sapiens

Alignment Length:	730	Identity:	195/730 - (26%)
Similarity:	316/730 - (43%)	Gaps:	164/730 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1457 SGNIGGAF----------------AVKNMTGAIYVAGALDYETRRRYELRLAASDNLKENYTTV- 1504
            ||:..||.                |.||:|  ::|...||.|       :|....||||.:|..
Human     7 SGSWNGALCRLLLLTLAILIFASDACKNVT--LHVPSKLDAE-------KLVGRVNLKECFTAAN 62

  Fly  1505 IIHVKDVN----------------------------------DNPPVFERPTYRTQITEEDDRNL 1535
            :||..|.:                                  :...:|....::|::.::  |:.
Human    63 LIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKK--RHT 125

  Fly  1536 PKRVLQ------------------------VTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDI 1576
            .::||:                        :.....|..:...|.|.:.|.|:|.: |.| .|.:
Human   126 KEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQE-PRN-LFYV 188

  Fly  1577 NRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFG 1641
            .|.||.::..:|:||:|   ...:....||....|........:.:.::|.|||.|||.:..|..
Human   189 ERDTGNLYCTRPVDREQ---YESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTF 250

  Fly  1642 NVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSP-IFEIEPDTGVIKTAVCC 1705
            .:.||...|..|..:.|.|.|:| :..:.||.|||    |.:...|| :|.:.|.||||.|....
Human   251 TIFENCRVGTTVGQVCATDKDEP-DTMHTRLKYSI----IGQVPPSPTLFSMHPTTGVITTTSSQ 310

  Fly  1706 LDRERTPDY--SIQVVAMDGG--GLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEM 1766
            ||||....|  .|:|..|||.  ||:.|.|..|.:.|:||..|.||:..:.|.|:|.    ..::
Human   311 LDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEEN----TVDV 371

  Fly  1767 PILTVTVHDEDETN----KFQYKVIDNSGYGADKF-TMVRNNDGTGSLKIVQPLDYEDQLQSNGF 1826
            .||.|||.|:|..|    :..|.::..:..|..|. |..:.|:|.  |.:|:||:||::.|
Human   372 EILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGV--LCVVKPLNYEEKQQ---- 430

  Fly  1827 RFRIQVNDKGEDND-------NDKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTEL 1884
             ..:|:   |..|:       :.:..::.:.|.|.:.| .|..|........|.:.|:.:|||..
Human   431 -MILQI---GVVNEAPFSREASPRSAMSTATVTVNVED-QDEGPECNPPIQTVRMKENAEVGTTS 490

  Fly  1885 EKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQN-GSVTIQRSLDREVVP----RHQVKILAID 1944
            ..:||.||:....|.:.|.  :.:|......|::| ||:.:.||||||...    .:.:.:||.|
Human   491 NGYKAYDPETRSSSGIRYK--KLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASD 553

  Fly  1945 DGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFR 2009
            .|.  :|.|.||.:|:||:|||:| |:.....::.:  |.....||:|.|.|:  ..:||||.|.
Human   554 QGG--RTCTGTLGIILQDVNDNSP-FIPKKTVIICK--PTMSSAEIVAVDPDE--PIHGPPFDFS 611

  Fly  2010 LDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKE-----YMIPIVIKDHGSPAMTG 2069
            |:.|..::.| .::::     |..|..|.:|        .|.:     |::||.::|.  ..|:.
Human   612 LESSTSEVQR-MWRLK-----AINDTAARLS--------YQNDPPFGSYVVPITVRDR--LGMSS 660

  Fly  2070 TSTLTVIIGD-VNDN 2083
            .::|.|.:.| :.:|
Human   661 VTSLDVTLCDCITEN 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637	21/107 (20%)
		Cadherin_repeat	1522..1630	CDD:206637	25/131 (19%)
		Cadherin_repeat	1638..1741	CDD:206637	40/107 (37%)
		Cadherin_repeat	1762..1861	CDD:206637	27/110 (25%)
		Cadherin_repeat	1871..1966	CDD:206637	34/99 (34%)
		Cadherin_repeat	1974..2083	CDD:206637	27/114 (24%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
DSC2	NP_077740.1	Cadherin_pro	31..111	CDD:214999	17/88 (19%)
		Cadherin	140..234	CDD:278457	19/98 (19%)
		Cadherin_repeat	247..351	CDD:206637	41/108 (38%)
		Cadherin	360..463	CDD:278457	29/116 (25%)
		Cadherin_repeat	477..573	CDD:206637	34/99 (34%)
		Cadherin_C	<852..896	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910