DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and DSC1

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_077739.1	Gene:	DSC1 / 1823	HGNCID:	3035	Length:	894	Species:	Homo sapiens

Alignment Length:	710	Identity:	201/710 - (28%)
Similarity:	298/710 - (41%)	Gaps:	165/710 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1471 GAIYVAGAL--------------DYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERP 1521
            |:||....|              |.:.|.:.|:::..|  .:||.:....|.||.     ..:|.
Human    75 GSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLS--ARENKSPKKRHTKDT-----ALKRS 132

  Fly  1522 TYR-----TQITEEDDRNLPKRVLQVTATDGDKDRPQN--IVYFLTGQGIDPDNPANSKFDINRT 1579
            ..|     ..:.|......|:.|.|:     ..|..||  |.|.::|.|:|.: |.| .|.|.:.
Human   133 KRRWAPIPASLMENSLGPFPQHVQQI-----QSDAAQNYTIFYSISGPGVDKE-PFN-LFYIEKD 190

  Fly  1580 TGEIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADVQ------------VNLKDINDNAP 1632
            ||:||..:.:||:        ::..||       |.|||...            :.::|.|||||
Human   191 TGDIFCTRSIDRE--------KYEQFA-------LYGYATTADGYAPEYPLPLIIKIEDDNDNAP 240

  Fly  1633 IFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTG 1697
            .|...|....|.||..:|..|..:||.|.|:| :..:.||.|.|.:.:.:....   |.|.||||
Human   241 YFEHRVTIFTVPENCRSGTSVGKVTATDLDEP-DTLHTRLKYKILQQIPDHPKH---FSIHPDTG 301

  Fly  1698 VIKTAVCCLDRERTPDYSIQVVAMDGG----GLKGTGTASIRVKDINDMPPQFTKDEWFTEVDET 1758
            ||.|....||||:...|.:.:...|.|    ||..|||.:|.::|.||.||.||:..:.|||:|.
Human   302 VITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEEN 366

  Fly  1759 DGTALPEMPILTVTVHDEDETN----KFQYKVIDNSGYGADKFTMVRN-NDGTGSLKIVQPLDYE 1818
                ..::.||.:.|.|:|..|    |..||::..:..|  .|.:..: |...|.|.:|:||:||
Human   367 ----RIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENG--NFIISTDPNTNEGVLCVVKPLNYE 425

  Fly  1819 DQLQSNGFRFRIQVNDKGEDNDNDKYHVAYS--------WVVVKLRDINDNKPHFERANVEVSVF 1875
            ...|     ..:||   |..|:......|.|        .|.||:.| :|..|........:...
Human   426 VNRQ-----VILQV---GVINEAQFSKAASSQTPTMCTTTVTVKIID-SDEGPECHPPVKVIQSQ 481

  Fly  1876 EDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQN-GSVTIQRSLDRE--VVPRHQ 1937
            :....|.||..:||.||:......:.|  .:..|....|.|||: |.:...:.||||  .|..:|
Human   482 DGFPAGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQ 544

  Fly  1938 --VKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKD------------YRPVLPEHVPPRKVV 1988
              :.::|:|  :..::.|.||.|.:.|.||:||:..|:            .:||.|:
Human   545 YNISVVAVD--AVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPD-------- 599

  Fly  1989 EILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEY 2053
                      ...|||||||.||.||.    .::.:|:.      ||...|  ||.........|
Human   600 ----------GPENGPPFQFFLDNSAS----KNWNIEEK------DGKTAI--LRQRQNLDYNYY 642

  Fly  2054 MIPIVIKD-HGSPAMTGTSTLTVIIGDV---NDNKMQPGS-KDIFVYNYQGQSPDTPIGR 2108
            .:||.||| ||   :..|..|||.:.|.   ::.:|:..| :|:        .|:..:||
Human   643 SVPIQIKDRHG---LVATHMLTVRVCDCSTPSECRMKDKSTRDV--------RPNVILGR 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637	13/56 (23%)
		Cadherin_repeat	1522..1630	CDD:206637	31/126 (25%)
		Cadherin_repeat	1638..1741	CDD:206637	38/106 (36%)
		Cadherin_repeat	1762..1861	CDD:206637	30/111 (27%)
		Cadherin_repeat	1871..1966	CDD:206637	28/99 (28%)
		Cadherin_repeat	1974..2083	CDD:206637	33/112 (29%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
DSC1	NP_077739.1	Cadherin_pro	29..109	CDD:214999	7/33 (21%)
		Cadherin	139..233	CDD:278457	28/115 (24%)
		Cadherin_repeat	249..350	CDD:206637	38/104 (37%)
		Cadherin	359..449	CDD:278457	29/103 (28%)
		Cadherin_repeat	485..573	CDD:206637	28/91 (31%)
		E_set	596..667	CDD:298831	31/103 (30%)
		Cadherin_C	<850..888	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9605
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910