DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN and Nrxn2

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_001356292.1 Gene:Nrxn2 / 18190 MGIID:1096362 Length:1710 Species:Mus musculus


Alignment Length:1752 Identity:340/1752 - (19%)
Similarity:542/1752 - (30%) Gaps:562/1752 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1589 LDRDQPNGRPQWRFTVFAQDE-----GGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGT 1648
            |..|.|....:|...:..:|.     ..:|....|:|:...:::...:.:|..|:       ...
Mouse   101 LQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGI-------PPD 158

  Fly  1649 AGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEP---------DTGVIKTAVC 1704
            ..:..:|::.|.|:.|..|..|.|........:....|......:|         ..|.:.|.:.
Mouse   159 VRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGAAADPLCAPARNPCANGGLCTVLA 223

  Fly  1705 -----------------CLDRER----------TPDYSIQVVAMDGGGLKGTGTASIRVKDINDM 1742
                             |.:.|.          ..:....:.:..|.|..|.|......|...:.
Mouse   224 PGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEF 288

  Fly  1743 PPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGADKFTMVRNNDGTG 1807
            ...|..:|:|.       ..|...||.:.|                      |:.|:....    
Mouse   289 VATFKGNEFFC-------YDLSHNPIQSST----------------------DEITLAFRT---- 320

  Fly  1808 SLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRD-------------IN 1859
                         ||.||....   ..|..|..|........|:|:.|..             .|
Mouse   321 -------------LQRNGLMLH---TGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFN 369

  Fly  1860 DNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQNGSVTI 1924
            ||..|            |.:|...|.:....  .....:|:.|.:                ::::
Mouse   370 DNAWH------------DVRVTRNLRQHAGI--GHAMVNKLHYLV----------------TISV 404

  Fly  1925 QRSLDREVVPRHQVKILAIDD----GSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPR 1985
            ...|......:....:|..||    |..|.||    .:....:::|....|||   |:.::...:
Mouse   405 DGILTTTGYTQEDYTMLGSDDFFYIGGSPNTA----DLPGSPVSNNFMGCLKD---VVYKNNDFK 462

  Fly  1986 KVVEILATDDDDRSKSNGPPFQFR------LDP----SADDII---RASFK----VEQDQKGANG 2033
            ..:..||.:.|.:.|..| ...||      |||    |.:..:   |.|.|    :..|.:....
Mouse   463 LELSRLAKEGDPKMKLQG-DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEP 526

  Fly  2034 DGMAVISSLR-------SFDREQQKEYMIP-------IVIKDHGSPAMTGTSTLTVIIGDVNDNK 2084
            :|:.:.|..|       |....|:.:|...       .::.|.||    |...|......|||.:
Mouse   527 NGLLLFSQGRRAGAGVGSHSSTQRADYFAMELLDGYLYLLLDMGS----GGIKLRASSRKVNDGE 587

  Fly  2085 ------MQPGSKDIFVYNYQGQSPDTPI---GRVYVYDLDD------------WDLPDKKFYWEA 2128
                  .:.|.|.....|    |..||.   |...|.||:.            .|||.....|.|
Mouse   588 WCHVDFQRDGRKGSISVN----SRSTPFLATGESEVLDLESELYLGGLPEGGRVDLPLPPEVWTA 648

  Fly  2129 MEHPRF-----------------KLDEDSGMVTM-----------------RAG--TREGRYHLR 2157
            .....:                 .|.|..|.|.:                 |.|  .|||  ..|
Mouse   649 ALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGICREG--WNR 711

  Fly  2158 F-----------KVYDRKHTQTDIPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQ 2211
            |           :|.:|:.|......::.:.:. :|......:..|.|..:|.    |.:.....
Mouse   712 FVCDCIGTGFLGRVCEREATVLSYDGSMYMKIM-LPTAMHTEAEDVSLRFMSQ----RAYGLMMA 771

  Fly  2212 SMSRSKMDRFRDKLADLLNTERENVDIFSVQLKRKHPPLTDVRFSAH--GSPYYKPVRLNGIVLM 2274
            :.||...|..|.:|.........|:|...|.......|  :..|:.|  ....:..||    |:.
Mouse   772 TTSRESADTLRLELDGGQMRLTVNLDCLRVGCAPSKGP--ETLFAGHKLNDNEWHTVR----VVR 830

  Fly  2275 HREEIEKDVGINIT----MVGIDECLYENQMCEGSCTNSLEISPLPYMVNANKTALVGVRVDTIA 2335
            ..:.::..|. |:|    |.|....|..:.:..|..|....||.:|.....:.:.||......:.
Mouse   831 RGKSLQLSVD-NVTVEGQMAGAHTRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMD 894

  Fly  2336 DCTCGARNFTKPESCRTTPCHNGGRCVDTRFGPHC--SCPVGYTGPRCQQTTRSFRGNGWAWYPP 2398
            .|..|          ..|.|.     ::.|||...  :.||.:       .:||    .:.....
Mouse   895 QCKDG----------DITYCE-----LNARFGLRAIVADPVTF-------KSRS----SYLALAT 933

  Fly  2399 LEMCDESHLSLEFITRKPDGLIIY---NGPIVPPERDETLISDFIALELERGYPRLLIDFGSGTL 2460
            |:.....||..:|.|..||||:::   ||            :|||.:||.:||...:.|.|:|..
Mouse   934 LQAYASMHLFFQFKTTAPDGLLLFNSGNG------------NDFIVIELVKGYIHYVFDLGNGPS 986

  Fly  2461 ELRVKTKKTLDDGEWHRIDLFWDTESIR-MVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPF 2524
            .::..:.|.::|.:||.:.:..|..::. :.:|   |..:.:..:|           ||.     
Mouse   987 LMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKID---SRTVTQHSNG-----------ARN----- 1032

  Fly  2525 NEYLNVNAPLQVGGLYREQFDQSLYFWHYMP----TAKGFDGCIRNLVHNSKLYDLAHPGLSR-- 2583
               |::...|.:|||.:..|..       :|    :..||.||:.::..|.:|.||....|.|  
Mouse  1033 ---LDLKGELYIGGLSKNMFSN-------LPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIG 1087

  Fly  2584 NSVAGCPQTEEVCAQTETTARCWEHGNCVGSLSEARCHC-RPGWTGPACNIPTIPTTF---KAQS 2644
            ....||......|    |...|...|.|:.......|.| ...:.||.||.|  .||:   |..:
Mouse  1088 QVERGCDGPSTTC----TEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDP--GTTYIFGKGGA 1146

  Fly  2645 YVKYALSFEP-DRFSTQVQ---LRFRTREEYGELFRVSDQHN-REYGILEIKDGHLHFRYNL--N 2702
            .:.|  ::.| ||.||::.   :.|.|.:....|.||..... .:|..|.|..|.:...:|:  :
Mouse  1147 LITY--TWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTD 1209

  Fly  2703 SLRTEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGE-GRRY------NETFEF------- 2753
            .:..:|.    ||| |:||::|||:..|.|..|||::|... ..||      ||....       
Mouse  1210 DITIDEP----NAI-VSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPY 1269

  Fly  2754 ----VGHQWLLVDK---------QEGVYAGGKAE------------YTGVRTFEVYADYQKSCLD 2793
                |..:||| ||         |..:..||:.:            |.|::...:.|:..    .
Mouse  1270 RLGRVVDEWLL-DKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESD----P 1329

  Fly  2794 DIRLEGKHLPL----PPAMNGTQWGQATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTC 2854
            ::|.|| ||.|    |..:...:....|:..::.........                .:...|.
Mouse  1330 NVRTEG-HLRLVGEGPSVLLSAETTATTLLADMATTIMETTT----------------TMATTTT 1377

  Fly  2855 GEGRIMSPDSKGCMDRNECLDMPCMNGATCINLEPRLRYRCICPDGFWGENCELVQEGQTLKLSM 2919
            ..||                 .|.|..:|..|.:.                              
Mouse  1378 RRGR-----------------SPTMRDSTTQNTDD------------------------------ 1395

  Fly  2920 GALAAILVCLLIILILVLVFVVYNRRREAHIKYPGPDDDVRENIINYDDEGGGE---DDMTAFDI 2981
                     ||:                |..:.|..|:|:.|    .:...|||   ..:|...:
Mouse  1396 ---------LLV----------------ASAECPSDDEDLEE----CEPSTGGELILPIITEDSL 1431

  Fly  2982 TPLQIPIGGP-MPPELAPMKMPIMYPVM--------TLMP--GQEPNVGMFIEEHKKRADGDPNA 3035
            .|..:....| :||.      |..||.:        ||.|  .:.|:.|...:  .:|.|.|...
Mouse  1432 DPPPVATRSPFVPPP------PTFYPFLTGVGATQDTLPPPAARRPSSGGPCQ--AERDDSDCEE 1488

  Fly  3036 PPFDDLRNYAYEGGGSTAGSL--SSLASGTDDEQQEYDYLGAWGPRFDKLANMYGPEAPNPH 3095
            |         .|..|..:|.:  |||.. ||||    |:...: |.......:..|..|.|:
Mouse  1489 P---------VEASGFASGEVFDSSLPP-TDDE----DFYTTF-PLVTDRTTLLSPRKPRPN 1535

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637
Cadherin_repeat 1083..1166 CDD:206637
Cadherin_repeat <1219..1298 CDD:206637
Cadherin_repeat 1310..1414 CDD:206637
Cadherin_repeat 1423..1514 CDD:206637
Cadherin_repeat 1522..1630 CDD:206637 8/45 (18%)
Cadherin_repeat 1638..1741 CDD:206637 18/138 (13%)
Cadherin_repeat 1762..1861 CDD:206637 17/111 (15%)
Cadherin_repeat 1871..1966 CDD:206637 13/98 (13%)
Cadherin_repeat 1974..2083 CDD:206637 29/139 (21%)
EGF 2350..2380 CDD:278437 7/31 (23%)
LamG 2385..2570 CDD:238058 44/192 (23%)
EGF_2 <2605..2631 CDD:285248 7/26 (27%)
Laminin_G_2 2665..2800 CDD:280389 44/176 (25%)
EGF_CA 2869..2907 CDD:238011 4/37 (11%)
Cadherin_C 2952..3088 CDD:279398 36/151 (24%)
Nrxn2NP_001356292.1 LamG 28..184 CDD:238058 17/89 (19%)
Laminin_G_2 318..456 CDD:308045 32/194 (16%)
LamG 516..666 CDD:214598 30/157 (19%)
EGF_CA 694..727 CDD:238011 8/34 (24%)
Laminin_G_2 760..890 CDD:308045 29/140 (21%)
Laminin_G_2 946..1074 CDD:308045 40/168 (24%)
Laminin_G_2 1169..1317 CDD:308045 40/153 (26%)
PHA03247 <1433..1630 CDD:223021 31/126 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1458..1508 15/61 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1621
Syndecan 1635..>1674 CDD:307260
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1677..1710
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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