DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and Notch2

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_035058.2	Gene:	Notch2 / 18129	MGIID:	97364	Length:	2473	Species:	Mus musculus

Alignment Length:	839	Identity:	163/839 - (19%)
Similarity:	235/839 - (28%)	Gaps:	366/839 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly  2293 DECLYE-------NQMCE--GSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNFTK-- 2346
            ::|.|.       ::.|:  |:|          :|::.          ||. :|||.. .||.
Mouse    99 EDCQYSTSHPCFVSRPCQNGGTC----------HMLSR----------DTY-ECTCQV-GFTGKQ 141

  Fly  2347 ---PESCRTTPCHNGGRCVDTRFGPHCSCPVGYTGPRCQ-------------------------- 2382
               .::|.:.||.||..|........|.||.|.||.:|:
Mouse   142 CQWTDACLSHPCENGSTCTSVASQFSCKCPAGLTGQKCEADINECDIPGRCQHGGTCLNLPGSYR 206

  Fly  2383 -QTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELER 2446
             |..:.|.|         :.||.     .::...|...:  ||.......|.|...:
Mouse   207 CQCPQGFTG---------QHCDS-----PYVPCAPSPCV--NGGTCRQTGDFTFECN-------- 247

  Fly  2447 GYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGT----- 2506
                .|..|...|.|      :.:||...|:                |::..:.  .||.
Mouse   248 ----CLPGFEGSTCE------RNIDDCPNHK----------------CQNGGVC--VDGVNTYNC 284

  Fly  2507 --PPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGL--------------------YREQFDQSLY 2549
              ||::....|     ....:|.|......|.||.                    ..|..|...|
Mouse   285 RCPPQWTGQFC-----TEDVDECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGDDCSENIDDCAY 344

  Fly  2550 ---------------FWHYMPTAKG------FDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQ-- 2591
                           |....|..|.      .|.||.|..|...|.| .:| |:...:..|||
Mouse   345 ASCTPGSTCIDRVASFSCLCPEGKAGLLCHLDDACISNPCHKGALCD-TNP-LNGQYICTCPQGY 407

  Fly  2592 -----TEEV--CAQTETTARCWEHGNCVGSLSEARCHCRPGWTGPACNIPTIPTTFKAQSYVKYA 2649
                 ||:|  ||...:.. |...|.||.:.....|.|..|:.||.|.:
Mouse   408 KGADCTEDVDECAMANSNP-CEHAGKCVNTDGAFHCECLKGYAGPRCEM---------------- 455

  Fly  2650 LSFEPDRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGH----------LHFRYNLNSL 2704
                                :..|..  ||....:...|:...|.          :|....:|..
Mouse   456 --------------------DINECH--SDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEVNEC 498

  Fly  2705 RTEEKDLWLNAIVVNDGQWHVVKVNRY---------GSAATLELD---------GGEGRRYNETF 2751
            ::..        .||:||. |.||||:         |....:::|         |.:...:...:
Mouse   499 QSNP--------CVNNGQC-VDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGY 554

  Fly  2752 E---FVGHQWLLVDK----------QEGVYAGGKAEYT---------GVRTFEVYADYQKSCLDD 2794
            |   ..|...:|.|:          ..|....|...||         .:.:.::...|...||:|
Mouse   555 ECQCATGFTGILCDENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLND 619

  Fly  2795 IRLEGKHLPLPPAMNGTQWG--QATMARNLE---KGCPSNKPCSNVICPDPFE------------ 2842
                |:.:.|   :||.|..  ..|...|.|   ..|.|| ||.:.:|.|...
Mouse   620 ----GRCIDL---VNGYQCNCQPGTSGLNCEINFDDCASN-PCMHGVCVDGINRYSCVCSPGFTG 676

  Fly  2843 --------------------CVDLWNVYECTCGEGRIMSPDSKGC-------------------- 2867
                                |::..|.:.|.|.||    |....|
Mouse   677 QRCNIDIDECASNPCRKGATCINDVNGFRCICPEG----PHHPSCYSQVNECLSNPCIHGNCTGG 737

  Fly  2868 ------------------MDRNECLDMPCMNGATCINLEPRLRYRCICPDGFWGENCEL 2908
                              :|:||||..||.||.||.||..  .|||.|..||.|.||::
Mouse   738 LSGYKCLCDAGWVGVNCEVDKNECLSNPCQNGGTCNNLVN--GYRCTCKKGFKGYNCQV 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	12/29 (41%)
		LamG	2385..2570	CDD:238058	37/232 (16%)
		EGF_2	<2605..2631	CDD:285248	9/25 (36%)
		Laminin_G_2	2665..2800	CDD:280389	31/184 (17%)
		EGF_CA	2869..2907	CDD:238011	21/37 (57%)
		Cadherin_C	2952..3088	CDD:279398
Notch2	NP_035058.2	EGF_CA	109..143	CDD:238011	11/55 (20%)
		EGF_CA	182..218	CDD:238011	3/44 (7%)
		EGF_CA	260..296	CDD:238011	9/58 (16%)
		EGF_CA	298..335	CDD:238011	5/36 (14%)
		EGF_CA	415..454	CDD:238011	12/39 (31%)
		EGF_CA	456..492	CDD:238011	6/37 (16%)
		EGF_CA	495..530	CDD:238011	11/43 (26%)
		EGF_CA	532..567	CDD:238011	4/34 (12%)
		EGF_CA	570..604	CDD:238011	4/33 (12%)
		EGF_CA	608..643	CDD:238011	11/41 (27%)
		EGF_CA	645..679	CDD:238011	7/34 (21%)
		EGF_CA	682..717	CDD:238011	7/38 (18%)
		EGF_CA	757..793	CDD:238011	21/37 (57%)
		EGF_CA	795..831	CDD:238011	163/839 (19%)
		EGF_CA	873..909	CDD:238011
		EGF_CA	911..947	CDD:238011
		EGF_CA	949..985	CDD:238011
		EGF_CA	987..1022	CDD:238011
		EGF_CA	1025..1061	CDD:238011
		EGF_CA	1117..1147	CDD:238011
		EGF_CA	1151..1185	CDD:238011
		EGF_CA	1188..1223	CDD:238011
		EGF_CA	1225..1262	CDD:238011
		EGF_CA	1264..1302	CDD:238011
		EGF_CA	<1312..1343	CDD:238011
		Notch	1423..1456	CDD:333809
		Negative regulatory region (NRR). /evidence=ECO:0000250	1425..1679
		NL	1459..1496	CDD:197463
		Notch	1501..1534	CDD:333809
		NOD	1540..1591	CDD:311024
		NODP	1621..1675	CDD:311559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1755..1778
		ANKYR	<1820..1932	CDD:223738
		ANK repeat	1828..1875	CDD:293786
		ANK 1	1828..1872
		ANK 2	1877..1906
		ANK repeat	1878..1908	CDD:293786
		ANKYR	1880..2067	CDD:223738
		ANK 3	1910..1940
		ANK repeat	1944..1975	CDD:293786
		ANK 4	1944..1973
		Ank_2	1949..2041	CDD:338493
		ANK repeat	1977..2008	CDD:293786
		ANK 5	1977..2006
		ANK repeat	2010..2041	CDD:293786
		ANK 6	2010..2039
		GGN	<2070..>2390	CDD:317988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2122..2169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2382..2473
		DUF3454	2385..2441	CDD:314760
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910