DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and nrx-1

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001263859.1	Gene:	nrx-1 / 179503	WormBaseID:	WBGene00007799	Length:	1725	Species:	Caenorhabditis elegans

Alignment Length:	537	Identity:	114/537 - (21%)
Similarity:	191/537 - (35%)	Gaps:	119/537 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  2251 TDVR----FSAHGSPYYKPVRLNGIVL-----MHREEIEKDVGINITMVGIDECLYE-------- 2298
            :|.|    |::..|..|.....:.|:|     ||.||:   |.|::|:: :|....|
Worm   340 SDARIIRMFNSFPSQRYDDDSWHTIILERSLQMHSEEM---VAIHMTLI-VDGRRDEIRQYAPEL 400

  Fly  2299 ----------------------NQMCEGSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGA 2341
                                  |::....|...:.     |.::|.:..||     .:||.:.|.
Worm   401 DWISNSFGFLGSIPKHNPSKEVNRVSFRGCMKKVR-----YDIDATRILLV-----NLADQSYGG 455

  Fly  2342 RNFTKPESCRTTPCHNGGRCVDTRFGPHCSCPVGYTGPRCQQTTRSF-RGNGWAWYPPLEMCDES 2405
             :..|.|...:..|.|                     |..:....|| ..:.:...|........
Worm   456 -SVVKTEGDISYSCKN---------------------PSQRSDVLSFTETSSYLTLPRWNSLSSG 498

  Fly  2406 HLSLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTL 2470
            .||..|.|...||||:|:|.:   :.:.|   |::|.||...:..::|:.|||.:.|:..:.| :
Worm   499 SLSFHFRTTSSDGLILYHGVM---QHNAT---DYVAFELIDSHLFMIINLGSGVVRLQTTSMK-V 556

  Fly  2471 DDGEWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQ 2535
            .|||||.:.|...:.:..::||..|.               |.|      .|..:..|.::.|:.
Worm   557 SDGEWHHVQLDRLSRTGSVIVDAIKI---------------DFS------TPGVSANLIIDDPIF 600

  Fly  2536 VGGLYREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVA---GCPQTEE--V 2595
            :|.:...........|. :...||:.|||:|:..|.....:.....:.||..   ||..:.|  :
Worm   601 IGNVPNNSLVYPSSVWS-IALQKGYTGCIKNIRMNGVSTKIGQEFEASNSTGIELGCSLSNELDI 664

  Fly  2596 CAQTETTARCWEHGNCVGSLSEARCHC-RPGWTGPACNIPTIPTTFKAQSYVKYALSFEPDRFST 2659
            |....    |...|.|..:|:...|.| ...:.|..|.:.........:....:.|:........
Worm   665 CEPNP----CQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHVLAHTKVSQVE 725

  Fly  2660 QVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWH 2724
            .:::||||....|.||........:...:.:.|..|:.  .|....|.....|..::  :|..||
Worm   726 HIKIRFRTTSSRGVLFDTGANGKNDKITVFLNDSQLNL--FLQDSSTNNTFSWGKSL--SDNHWH 786

  Fly  2725 VVKVNRYGSAATLELDG 2741
            .::|.|.|....|.|||
Worm   787 ELQVRRLGQKLLLYLDG 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	2/29 (7%)
		LamG	2385..2570	CDD:238058	46/185 (25%)
		EGF_2	<2605..2631	CDD:285248	7/26 (27%)
		Laminin_G_2	2665..2800	CDD:280389	21/77 (27%)
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
nrx-1	NP_001263859.1	LamG	36..180	CDD:238058
		Laminin_G_2	303..437	CDD:280389	18/105 (17%)
		LamG	477..634	CDD:238058	46/185 (25%)
		EGF_CA	663..698	CDD:238011	8/38 (21%)
		Laminin_G_2	731..852	CDD:280389	21/77 (27%)
		LamG	885..1042	CDD:238058
		Laminin_G_2	1138..1274	CDD:280389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910