DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and EGFLAM

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_001192230.1 Gene:EGFLAM / 133584 HGNCID:26810 Length:1017 Species:Homo sapiens


Alignment Length:1014 Identity:211/1014 - (20%)
Similarity:339/1014 - (33%) Gaps:338/1014 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  2003 GPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKDHGSPAM 2067
            |||...:|...........:|:.: ..|:...|..|..|....|:..|::.        |..|..
Human    36 GPPLDIKLGALNCTAFSIQWKMPR-HPGSPILGYTVFYSEVGADKSLQEQL--------HSVPLS 91

  Fly  2068 TGTSTLTVIIGDVNDNKMQPGSK---DIFVYNYQGQSPDTPIGRVYVYDLDDWDLPDKKFYWEAM 2129
            ....|...:|||     ::||::   .|..|:..|:      ||                    :
Human    92 RDIPTTEEVIGD-----LKPGTEYRVSIAAYSQAGK------GR--------------------L 125

  Fly  2130 EHPRF--KLDEDSGMVTMRAGTREGRYHLRFKVYDRKHTQTDIPANVTVTVREIPHEAVVNSGSV 2192
            ..||.  .|.:||.:.                           ||     ..:.||..||:...|
Human   126 SSPRHVTTLSQDSCLP---------------------------PA-----APQQPHVIVVSDSEV 158

  Fly  2193 RLS---GISD--------------EDFIRVWNYRTQSMSRSKMDRFRDKLADLLNTERENVDIFS 2240
            .||   |.|:              .||.:.|   |....|.:||....|..| .:|..:    |:
Human   159 ALSWKPGASEGSAPIQYYSVEFIRPDFDKKW---TSIHERIQMDSMVIKGLD-PDTNYQ----FA 215

  Fly  2241 VQLKRKHPP---------LTDVRFSAHGSPYYKPVRLNGIVLMHREE-IEKDVGINITMVGIDEC 2295
            |:....|.|         :..:.....||..|.|..:..:.....:| .|.|:.::|:       
Human   216 VRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDIS------- 273

  Fly  2296 LYENQMCEGSCTNSLEISPLPYMVNANKTALV----------------------GVRVDTIA--- 2335
             :|            |:.|||.....||..||                      .:.|.|:|   
Human   274 -FE------------EVKPLPATKGGNKKFLVESKKMSISNPKTISRLIPPTSASLPVTTVAPQP 325

  Fly  2336 ---------DCTCGARNFTKPESCRTTPCHNGGRCVD--TRFGPHCSCPVGYTGPRCQQTT---- 2385
                     .....:|.|..|  |..|.|.....||:  |..|..|.|.:|..|..|.:..    
Human   326 IPIQRKGKNGVAIMSRLFDMP--CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQY 388

  Fly  2386 RSFRGNGWAWYPPLEMCDES-HLSLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYP 2449
            ..|.|:.:..:.||:...:: .::|||.....|||::|.|      .:|....||::|.:.|...
Human   389 PQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCG------ENEHGRGDFMSLAIIRRSL 447

  Fly  2450 RLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMS 2514
            :...:.|:|...:..:||..|  |.||.:.|:.|..:           .:.::.:|||     ::
Human   448 QFRFNCGTGVAIIVSETKIKL--GGWHTVMLYRDGLN-----------GLLQLNNGTP-----VT 494

  Fly  2515 CQARGQIPPFNEYLNVNAPLQVGGLYREQFDQSLYFWHYMPTA--KGFDGCIRNLVHNSKLYDLA 2577
            .|::||.    ..:....||.:||.      .|.| |....|.  :||.||:::|..|.:..|: 
Human   495 GQSQGQY----SKITFRTPLYLGGA------PSAY-WLVRATGTNRGFQGCVQSLAVNGRRIDM- 547

  Fly  2578 HP-----GLSRNSVAGCPQTEEVCAQTETTARCWEHGNCVGSLSEAR-CHCRPGWTGPACN---I 2633
            .|     .||...|..|  :..:|.:    |.|...|.|....:::. |.|..|:.|..|.   .
Human   548 RPWPLGKALSGADVGEC--SSGICDE----ASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFT 606

  Fly  2634 PTIPTTFKA-QSYVKYALSFEPDRFST--QVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHL 2695
            .|||...:: :||.......||..:.:  :.::.||.....|.|....|..::::..:.:..||:
Human   607 LTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHV 671

  Fly  2696 HFRYNLNS----LRTEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEGRRYNETFEFVGH 2756
            .||::..|    ||:|:.        :..|.||.::|:|......|::|               .
Human   672 EFRFDCGSGTGVLRSEDP--------LTLGNWHELRVSRTAKNGILQVD---------------K 713

  Fly  2757 QWLLVDKQEG----------VYAGGKAEYTGV-------RTFEVYADYQKSCLDDIRLEGKHLPL 2804
            |.::....||          ::.||...|..|       :.|.  ...||..|:|..:..||   
Human   714 QKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFS--GSIQKIILNDRTIHVKH--- 773

  Fly  2805 PPAMNGTQWGQATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRIMSPDSKGCMD 2869
                      ..|...|:|...                                           
Human   774 ----------DFTSGVNVENAA------------------------------------------- 785

  Fly  2870 RNECLDMPCMNGATCINLEPRLR-YRCICPDGFWGENCE 2907
             :.|:..||.:|.:|   .||.. |.|.||.||.|.:|:
Human   786 -HPCVRAPCAHGGSC---RPRKEGYDCDCPLGFEGLHCQ 820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637
Cadherin_repeat 1083..1166 CDD:206637
Cadherin_repeat <1219..1298 CDD:206637
Cadherin_repeat 1310..1414 CDD:206637
Cadherin_repeat 1423..1514 CDD:206637
Cadherin_repeat 1522..1630 CDD:206637
Cadherin_repeat 1638..1741 CDD:206637
Cadherin_repeat 1762..1861 CDD:206637
Cadherin_repeat 1871..1966 CDD:206637
Cadherin_repeat 1974..2083 CDD:206637 17/79 (22%)
EGF 2350..2380 CDD:278437 11/31 (35%)
LamG 2385..2570 CDD:238058 46/191 (24%)
EGF_2 <2605..2631 CDD:285248 7/26 (27%)
Laminin_G_2 2665..2800 CDD:280389 32/155 (21%)
EGF_CA 2869..2907 CDD:238011 14/38 (37%)
Cadherin_C 2952..3088 CDD:279398
EGFLAMNP_001192230.1 FN3 36..133 CDD:238020 26/136 (19%)
FN3 142..234 CDD:238020 25/104 (24%)
LamG 391..541 CDD:238058 46/184 (25%)
EGF_CA 560..602 CDD:238011 11/47 (23%)
LamG 618..765 CDD:238058 34/171 (20%)
EGF_CA <792..820 CDD:238011 13/30 (43%)
Laminin_G_2 868..993 CDD:280389
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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