back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and AgaP_AGAP006732

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_309012.4	Gene:	AgaP_AGAP006732 / 1270327	VectorBaseID:	AGAP006732	Length:	1267	Species:	Anopheles gambiae

Alignment Length:	1676	Identity:	391/1676 - (23%)
Similarity:	634/1676 - (37%)	Gaps:	565/1676 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   963 DNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKGTKFTVDEETGE 1027
            ::||.|.:|..|.|..:|....|:.|::|.|||.|:  :..:||||..:..|: ..|.:||:|||
Mosquito    32 NHKPSFHNCGEYKPTFKEEQEPGTSVLRVTATDPDQ--SQTIKYSIANETRQE-QLFAIDEDTGE 93

  Fly  1028 VSTNKVFDREGD--DGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFDRQKYVENVKQD 1090
            :|:..:|||:..  |.:|. :||:|||.|.|||:.||:..:.|.|:|||||:||:..|...|..:
Mosquito    94 ISSAYIFDRDPPYRDTEFY-ITVRATDNGQPSLDDVCTIKLMILDINDNPPVFDKDFYEVFVSMN 157

  Fly  1091 ASIGTNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVLKKPLDGCYPRDRYRL 1155
            .::...:..::|.|.|.:.|..:.:.:...:  .|..||||...:|.:.|.|.:|. .|.:.|.|
Mosquito   158 TTLRQQVTIITAKDIDDETNNVVNFEIVQEY--KDDSYFEIDQHTGVLTLAKRIDR-NPGEYYAL 219

  Fly  1156 RVSASDKG---TPASAADVDVELDVVDRNNKPPIWDKSIYGPIHIRENVTVGTVVTSV-KASSGI 1216
            ||.|.::|   ..:.:.:|||::.:::.:.:.|.:.|....|:.:.||.|....|.:| :|:|.|
Mosquito   220 RVRAYNQGCIENESDSPEVDVKIHIINADKRLPYFTKVPEAPVILHENFTAFQQVLAVFEANSNI 284

  Fly  1217 EGNPTVFYRLMPGSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEYNLTIRVENNGAQ 1281
            ....|:.                                       :|..::|..|::.||
Mosquito   285 NNESTII---------------------------------------FEIFRDYKPTLQEEN---- 306

  Fly  1282 QLASEATVYIMLEDVNDEIPLFTEREQETVLEGEPIGTKVTQVNAIDKDGTFPNNQVYYYIVDSP 1346
                                             || ||.|.:|.|.|.|   .:..:.|.|.:..
Mosquito   307 ---------------------------------EP-GTSVIRVTATDPD---QSQTIKYSIANET 334

  Fly  1347 RNEGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPSARPNSNGPNSVTKFIRIGIADK 1411
            |.:  :.|.|:..:||||:..:|||:
Mosquito   335 RQQ--QLFAIDEDTGEIFSAYIFDRD--------------------------------------- 358

  Fly  1412 NDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGAIYVA 1476
               |||.|...|              :||.|.|:                         |..|:
Mosquito   359 ---PPYRDTEFY--------------ITVRATDN-------------------------GQPYL- 380

  Fly  1477 GALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTYRTQITEEDDRNLPKRVLQ 1541
                                  ::..|:.:.:.|:|||||||::..|...::.  :..|.::|..
Mosquito   381 ----------------------DDVCTIKVKILDINDNPPVFDKDYYEAFVSM--NTTLHQQVAI 421

  Fly  1542 VTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFA 1606
            :||.|.| |...|:|.|    .|..:....|.|:|::.||.:.:.|.:||   |....:...|.|
Mosquito   422 ITAKDID-DETNNVVNF----EIVQEYKDGSYFEIDQHTGVLTLAKRIDR---NPGEYYALRVRA 478

  Fly  1607 QDEG-----GEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVT-------ENGTAGMVVMTMTAV 1659
            .::|     .|.|  ..||:|::.|.:...|      ||..|.       ||.||...|:   ||
Mosquito   479 YNQGYIEHESENL--EVDVKVHIIDADKRLP------YFTKVPEVPVILHENFTAFDQVL---AV 532

  Fly  1660 DYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIE--PDTGVIKTAVCCLDRERTPDYSIQVVAMD 1722
            ...:.|..:::.:::.|.:...|:......|.:|  .:|..||.| ..||.|...:|:|.|:|.:
Mosquito   533 FEANSNINNDSNVIFEIVRGTFEQTNSMNTFLLEQIENTAHIKLA-RALDYESVTEYTITVIATN 596

  Fly  1723 GGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKVI 1787
            ...|.......|.:.|:||..|...||                             .:..||::|
Mosquito   597 RHNLAAEAVVKIMILDVNDNVPVIIKD-----------------------------VSCVQYELI 632

  Fly  1788 DNSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVV 1852
            |||                       |:            |:|...|....:.|
Mosquito   633 DNS-----------------------PV------------FQIHAYDLDGTSAN----------- 651

  Fly  1853 VKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAIN 1917
                            |:                             :||||..|:  |:.|.|:
Mosquito   652 ----------------NI-----------------------------ISYSIAESN--QQHFTID 669

  Fly  1918 QN-GSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEH 1981
            .: |:||.|..|                                  .||.     ||....: .:
Mosquito   670 SHTGTVTKQNRL----------------------------------YNDE-----KDIHNAI-TN 694

  Fly  1982 VPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFD 2046
            :|.:           ::..||...||..|..|.|
Mosquito   695 IPAQ-----------EQRSSNDNTFQNVLSISND------------------------------- 717

  Fly  2047 REQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYV 2111
             .|.:::.                                 ..:.|.|.||:|...|..||.:||
Mosquito   718 -YQNRDFF---------------------------------NRRYIMVNNYEGMLTDKLIGSIYV 748

  Fly  2112 YDLDDWDLPD---KKFYWE------AMEHPRFKLDEDSGMVTMRAGTREGRYHLRFKVYDR---- 2163
                |:|:.|   |.|.|:      ..:|  |.|:..:||:.|...|.||.|:|.|.|.:.
Mosquito   749 ----DYDIKDNSNKLFLWDERASTGTRKH--FTLNYKTGMMMMVKSTPEGIYNLEFTVIEESSCF 807

  Fly  2164 -KHTQTDIPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDKLAD 2227
             :|   ::.|.|||.|:.|..:.|..|||:|...::.|.||.    :|.|...:.:.|.:..:|.
Mosquito   808 PRH---NVSAYVTVKVKNISAKTVNQSGSIRFYNVTAETFIS----QTLSELNTPLYRLQQSIAS 865

  Fly  2228 LLNTERENVDIFSV-QLKRKHPPLTDVRFSAHGSPYYKPVRLNGIVLMHREEIEKDVGINITMVG 2291
            :|:|..:.||||:: ..|.......||.|:...:.|.....||.::.:|..::|:|||..|..||
Mosquito   866 ILDTSPDQVDIFTINNRKLAGGSFLDVFFAVDDTIYTSSEVLNAVLSLHLRKLEEDVGYRIVSVG 930

  Fly  2292 IDECLYENQMCEGSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNFTKPE-SCRTTPC 2355
            ||||:.:..||:.:|.|.:..|..|.:|:.|.::.||:.....|.|.        |: ......|
Mosquito   931 IDECIAKGHMCKQACKNKVHRSQKPIVVHTNTSSFVGMTTLVQAQCI--------PQIESSLVAC 987

  Fly  2356 HNGGRCVDTRFGPHCSCPVGYTGPRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLI 2420
            .|||.|.:.:    |:||:|:.||:|::....|.|.|:|.||.:...:.:::|:|.:.|:.|||:
Mosquito   988 LNGGTCQNGK----CNCPMGFEGPQCEKLDICFDGIGYAIYPSINSGNVNNISIELLPRQKDGLV 1048

  Fly  2421 IYNGPI-------VPPERDETLISDFIALELERGYPRLLIDFGSGTL-----ELRVKTKKTLDDG 2473
            .|.||:       .||         |:|||:..|...||:|:|:|.:     :|.:.|..|:|..
Mosquito  1049 FYMGPLKYDPSLKTPP---------FLALEINDGMLVLLLDYGTGMIRFEHQQLILHTVTTVDIV 1104

  Fly  2474 -EWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVG 2537
             |.||.::...:..::                        .|.::|.:....:.:|..|.|:.:|
Mosquito  1105 LEPHRFEIHTASNKLK------------------------GSSRSRYENKDLSGFLPGNMPILLG 1145

  Fly  2538 GLYREQFDQSLYFW--HYM--PTAKGFDGCIRNLVHNSKLYDLAHPGLSRN 2584
            |.........||.|  |.:  |....|:||:|||..|....|...|.::.|
Mosquito  1146 GTVNHFAKYLLYNWPLHLLGTPETLDFNGCMRNLTINGHTIDFMLPMVANN 1196

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.