DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and Celsr1

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:XP_006520442.1 Gene:Celsr1 / 12614 MGIID:1100883 Length:3039 Species:Mus musculus


Alignment Length:2084 Identity:506/2084 - (24%)
Similarity:816/2084 - (39%) Gaps:535/2084 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   973 TYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKGT-KFTVDEETGEVSTNKVFDR 1036
            :|...|.|..|.|:.||::.|.|.|:|..|::.|.:....:::.. .|.:|..||.|:|.:..||
Mouse   264 SYQVSVPENEPAGTAVIELRAHDPDEGDAGRLSYQMEALFDERSNGYFLIDAATGAVTTARSLDR 328

  Fly  1037 EGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFDRQKYVENVKQDASIGTNILRVS 1101
            |..|...:.|:  |.|.|.|........||.::|.||:.|:|::.:|.|.::::..:|..:|.:.
Mouse   329 ETKDTHVLKVS--AVDHGSPRRSAATYLTVTVSDTNDHSPVFEQSEYRERIRENLEVGYEVLTIR 391

  Fly  1102 ASDEDADNNGAIVYSLTAPFNPNDLE----YFEIQAESGWIVLKKPLDGCYPRD---RYRLRVSA 1159
            |:|.||.:|..:.|.|        ||    .|||.|.||.:..:..:|    |:   .|:|.|.|
Mouse   392 ATDGDAPSNANMRYRL--------LEGAGGVFEIDARSGVVRTRAVVD----REEAAEYQLLVEA 444

  Fly  1160 SDKGT---PASAADVDVELDVVDRNNKPPIWDKSIYGPIHIRENVTVGTVVTSVKASSGIEG-NP 1220
            :|:|.   |.||: ..|.:.|.|.|:..|.:.:..| .:.:.|:|.|.|.|..|:|:...:| |.
Mouse   445 NDQGRNPGPLSAS-ATVHIVVEDENDNYPQFSEKRY-VVQVPEDVAVNTAVLRVQATDRDQGQNA 507

  Fly  1221 TVFYRLMPGSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEYNLTIRVENNGAQQLA- 1284
            .:.|.::.|     |....|||.....:.|      |.:|||:|:|:||.|.|:.::.|...|. 
Mouse   508 AIHYSIVSG-----NLKGQFYLHSLSGSLD------VINPLDFEAIREYTLRIKAQDGGRPPLIN 561

  Fly  1285 SEATVYIMLEDVNDEIPLFTERE-QETVLEGEPIGTKVTQVNAIDKDGTFPNNQVYYYIVD---- 1344
            |...|.:.:.||||..|:|.... |..|||..|:|..|..:.|:|.|.. .|.::.|.:||    
Mouse   562 SSGLVSVQVLDVNDNAPIFVSSPFQAAVLENVPLGHSVLHIQAVDADAG-ENARLQYRLVDTAST 625

  Fly  1345 ----------SPRNEGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARD-GAPSARPNSNGPN 1398
                      :|.:.....|:|:..||.|......|||:...|:..|||.| |:|:...:::   
Mouse   626 IVGGSSVDSENPASAPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPAMSSSAS--- 687

  Fly  1399 SVTKFIRIGIADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGNIGGA 1463
                 :.|.:.|.|||.|.|.:.:||..::|:..:..:|||:.|:|.|.:|.|.|::|.||....
Mouse   688 -----VSITVLDVNDNDPMFTQPVYELRLNEDAAVGSSVLTLRARDRDANSVITYQLTGGNTRNR 747

  Fly  1464 FAVKNMTGA--IYVAGALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTYRTQ 1526
            ||:.:.:|.  |.:|..|||:..|:|.|.:.|||..:.:...|.|:|.|.|.:.|||:...|...
Mouse   748 FALSSQSGGGLITLALPLDYKQERQYVLAVTASDGTRSHTAQVFINVTDANTHRPVFQSSHYTVS 812

  Fly  1527 ITEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDR 1591
            ::|  ||.:...:..::|||.|......|.|.|       ::|. .:|.|:..||.|:.:..||.
Mouse   813 VSE--DRPVGTSIATISATDEDTGENARITYVL-------EDPV-PQFRIDPDTGTIYTMTELDY 867

  Fly  1592 DQPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTM 1656
            :.   :..:...:.|||.|.........:::.:.|.|||||.|.:..|.|:|.|:......|:.:
Mouse   868 ED---QAAYTLAITAQDNGIPQKSDTTSLEILILDANDNAPRFLRDFYQGSVFEDAPPSTSVLQV 929

  Fly  1657 TAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAM 1721
            :|.|.|   .|.|.||:|:.:..    :.|...|.|||.:|||:|. ..||||....|::..:|:
Mouse   930 SATDRD---SGPNGRLLYTFQGG----DDGDGDFYIEPTSGVIRTQ-RRLDRENVAVYNLWALAV 986

  Fly  1722 DGGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKV 1786
            |.|.                                                             
Mouse   987 DRGS------------------------------------------------------------- 990

  Fly  1787 IDNSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWV 1851
                                     ..||.....:|                             
Mouse   991 -------------------------PNPLSASVGIQ----------------------------- 1001

  Fly  1852 VVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAI 1916
             |.:.|||||.|.||:..:|:.|.|::.||:.:.:.:|.|||:|..:::.|.|            
Mouse  1002 -VSVLDINDNPPVFEKDELELFVEENSPVGSVVARIRANDPDEGPNAQIMYQI------------ 1053

  Fly  1917 NQNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEH 1981
                                                          :..|.|:.           
Mouse  1054 ----------------------------------------------VEGNVPEV----------- 1061

  Fly  1982 VPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFD 2046
                                      |:||..:.|                      :.:|...|
Mouse  1062 --------------------------FQLDLLSGD----------------------LRALVELD 1078

  Fly  2047 REQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQ-PGSKDIF---VYNYQGQSPDTPIG 2107
            .|.:::||  :|::...:| :...:|:.:.:.|.|||..: |..:.:|   |.|.....|...||
Mouse  1079 FEVRRDYM--LVVQATSAP-LVSRATVHIRLLDQNDNPPELPDFQILFNNYVTNKSNSFPSGVIG 1140

  Fly  2108 RVYVYDLDDWDLPDKKFY--WEAMEHPRFKLDEDSGMVTMRAGTREGR---YHLRFKVYDRKHTQ 2167
            |:..:|.   ||.|...|  .:..|.....||..:|.:.:.......|   ..:...|.|..|:.
Mouse  1141 RIPAHDP---DLSDSLNYTFLQGNELSLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSV 1202

  Fly  2168 TDIPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDKLADLLNTE 2232
            |   |..|:.|..|..:.:.||.:|||..:|.|.|:           ...:..|.:.:|.:|:|.
Mouse  1203 T---ALCTLRVTIITDDMLTNSITVRLENMSQEKFL-----------SPLLSLFVEGVATVLSTT 1253

  Fly  2233 RENVDIFSVQLKRK-HPPLTDVRFSAHGSPYYKPVRLNGIVLMHREEIEKDVGINITM------- 2289
            ::::.:|::|.... ...:.:|.|||     ..|....| .....|::::.:.:|.|:       
Mouse  1254 KDDIFVFNIQNDTDVSSNILNVTFSA-----LLPGGTRG-RFFPSEDLQEQIYLNRTLLTTISAQ 1312

  Fly  2290 --VGIDECLYENQMCEG--SCTNSLEI-SPLPYMVNANKTAL-------VGVR------------ 2330
              :..|:.:...:.||.  .|.:.|.. |..|::  ::.|.|       .|:|            
Mouse  1313 RVLPFDDNICLREPCENYMKCVSVLRFDSSAPFI--SSTTVLFRPIHPITGLRCRCPPGFTGDYC 1375

  Fly  2331 ---VDTIADCTCGA----------------RNFT--------KPESCRTTPCHNGGRCVDTRFGP 2368
               :|......|||                .:||        :...|.:..|.|||.||:...|.
Mouse  1376 ETEIDLCYSNPCGANGRCRSREGGYTCECFEDFTGEHCQVNVRSGRCASGVCKNGGTCVNLLIGG 1440

  Fly  2369 -HCSCPVG-YTGPRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYNGPIVPPER 2431
             ||.||.| |..|.|:.:||||....:..:..|.......:||.|.|:..:.|::|||...... 
Mouse  1441 FHCVCPPGEYEHPYCEVSTRSFPPQSFVTFRGLRQRFHFTVSLAFATQDRNALLLYNGRFNEKH- 1504

  Fly  2432 DETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFW-------------- 2482
                  ||||||:.....:|....|..|..:..:....:.||.||.:.:.:              
Mouse  1505 ------DFIALEIVEEQLQLTFSAGETTTTVTPQVPGGVSDGRWHSVLVQYYNKPNIGHLGLPHG 1563

  Fly  2483 -DTESIRMV-VDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGLYREQFD 2545
             ..|.:.:| ||.|.:|.......    ...:.||.|:|......:.|::..||.:||:.....|
Mouse  1564 PSGEKVAVVTVDDCDAAVAVHFGS----YVGNYSCAAQGTQSGSKKSLDLTGPLLLGGVPNLPED 1624

  Fly  2546 QSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCAQTETTARCWEHGN 2610
            ..::       ::.|.||:|||..:.::.|:|....:..:.|||......|..|.    |...|.
Mouse  1625 FPVH-------SRQFVGCMRNLSIDGRIVDMAAFIANNGTRAGCASQRNFCDGTS----CQNGGT 1678

  Fly  2611 CVGSLSEARCHCRPGWTGPACN--IPTIPTTFKAQSYVKYALSFEPDRFST-----QVQLRFRTR 2668
            ||...:...|.|...:.|..|.  :|. |..|..:|.|.::     |...|     .:.|.||||
Mouse  1679 CVNRWNTYLCECPLRFGGKNCEQAMPH-PQRFTGESVVLWS-----DLDITISVPWYLGLMFRTR 1737

  Fly  2669 EEYGELFRV-----SDQHNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVVKV 2728
            :|.|.|...     |..|      |:|.:.::.|..:...  ::...:.|:...:.||.||.:.:
Mouse  1738 KEDGVLMEATAGTSSRLH------LQILNSYIRFEVSYGP--SDVASMQLSKSRITDGGWHHLLI 1794

  Fly  2729 N----------RYGSAATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAE-YTGVR-TF 2781
            .          :|  .|.:.||.|    .:::...:|:| |...|...:..||..| ...|| .|
Mouse  1795 ELRSAKEGKDIKY--LAVMTLDYG----MDQSTVQIGNQ-LPGLKMRTIVIGGVTEDKVSVRHGF 1852

  Fly  2782 EVYADYQKSCLDDIRLEGKHLPLPPAMNGTQWGQATMARN------LEKGCPSNKPCSNVICPDP 2840
                   :.|:..:|           |..|....||:..|      ::.||....||::..||..
Mouse  1853 -------RGCMQGVR-----------MGETSTNIATLNMNDALKVRVKDGCDVEDPCASSPCPPH 1899

  Fly  2841 FECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPCMNGATCINL--EPRLRYRCICPDGFWG 2903
            ..|.|.|:.|.|.|..|..    .|.|:|  .||..||.:.|.|:..  .|| .|.|.|..|.:|
Mouse  1900 SHCRDTWDSYSCICDRGYF----GKKCVD--ACLLNPCKHVAACVRSPNTPR-GYSCECGPGHYG 1957

  Fly  2904 ENCE 2907
            :.||
Mouse  1958 QYCE 1961

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637 32/101 (32%)
Cadherin_repeat 1083..1166 CDD:206637 27/92 (29%)
Cadherin_repeat <1219..1298 CDD:206637 24/79 (30%)
Cadherin_repeat 1310..1414 CDD:206637 32/118 (27%)
Cadherin_repeat 1423..1514 CDD:206637 34/92 (37%)
Cadherin_repeat 1522..1630 CDD:206637 25/107 (23%)
Cadherin_repeat 1638..1741 CDD:206637 30/102 (29%)
Cadherin_repeat 1762..1861 CDD:206637 7/98 (7%)
Cadherin_repeat 1871..1966 CDD:206637 12/94 (13%)
Cadherin_repeat 1974..2083 CDD:206637 14/108 (13%)
EGF 2350..2380 CDD:278437 14/31 (45%)
LamG 2385..2570 CDD:238058 48/200 (24%)
EGF_2 <2605..2631 CDD:285248 7/25 (28%)
Laminin_G_2 2665..2800 CDD:280389 34/151 (23%)
EGF_CA 2869..2907 CDD:238011 14/39 (36%)
Cadherin_C 2952..3088 CDD:279398
Celsr1XP_006520442.1 Cadherin_repeat 264..364 CDD:206637 32/101 (32%)
Cadherin_repeat 372..470 CDD:206637 34/110 (31%)
Cadherin_repeat 479..576 CDD:206637 34/108 (31%)
Cadherin_repeat 584..698 CDD:206637 33/122 (27%)
Cadherin_repeat 706..800 CDD:206637 34/93 (37%)
Cadherin_repeat 808..903 CDD:206637 25/107 (23%)
Cadherin_repeat 912..1010 CDD:206637 37/221 (17%)
Cadherin_repeat 1018..1112 CDD:206637 28/213 (13%)
Cadherin_repeat 1132..1213 CDD:206637 21/86 (24%)
EGF_CA 1379..1414 CDD:238011 6/34 (18%)
EGF_CA 1422..1456 CDD:238011 15/33 (45%)
LamG 1459..1642 CDD:238058 48/200 (24%)
EGF_CA 1666..1700 CDD:238011 9/37 (24%)
Laminin_G_2 1734..1861 CDD:366983 34/159 (21%)
EGF_CA 1889..1923 CDD:238011 12/37 (32%)
EGF_CA 1923..1961 CDD:238011 14/40 (35%)
TNFRSF <1930..2026 CDD:389949 13/33 (39%)
CRD3 1951..2000 CDD:276900 5/11 (45%)
CRD4 2002..2026 CDD:276900
EGF_Lam 2017..>2055 CDD:238012
HormR 2067..2128 CDD:214468
GAIN 2145..2396 CDD:374574
GPS 2422..2475 CDD:197639
7tmB2_CELSR1 2480..2733 CDD:320657
TM helix 1 2483..2507 CDD:320657
TM helix 2 2516..2537 CDD:320657
TM helix 3 2547..2569 CDD:320657
TM helix 4 2588..2604 CDD:320657
TM helix 5 2623..2646 CDD:320657
TM helix 6 2666..2691 CDD:320657
TM helix 7 2695..2720 CDD:320657
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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