DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and Cdh23

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:XP_038954289.1 Gene:Cdh23 / 114102 RGDID:619760 Length:3352 Species:Rattus norvegicus


Alignment Length:2432 Identity:652/2432 - (26%)
Similarity:986/2432 - (40%) Gaps:446/2432 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 EMSLVLPHDTYPGFSIKKFKTHPVKINGSSHSGAAAYHMLDTDYS-------KY--------FTV 120
            :::|:..:|..|.||...:.   |.:..:...|.:...:|.||..       .|        |::
  Rat   445 KITLINENDNRPIFSQPLYN---VSLYENITVGTSVLTVLATDNDVGTFGEVNYFFSDDPDRFSL 506

  Fly   121 LED-GVVMTTADIS-PLVNRPVQLVVVEQTPNATNTHNLQLFVMHRNDML-RFSGSLLDA-SGEV 181
            .:| |::|..|.:. .|:.|....|:.........|..:::.|:..||.: .|.   .|| .|.:
  Rat   507 DKDTGLIMLIARLDYELIQRFTLTVIARDGGGEETTGRVRINVLDVNDNVPTFQ---KDAYVGAL 568

  Fly   182 RENQPAGT---RVRGVPLMQAFSGSILDEELATPKKVRYTII---------DGNVDDAFAL---- 230
            |||:|:.|   |:|..           ||:......:.|:|:         |.:|.:.:.:    
  Rat   569 RENEPSVTQLVRLRAT-----------DEDSPPNNLITYSIVNASAFGSYFDISVYEGYGVISVS 622

  Fly   231 ----QERKAN-----------------------------------------------KNIQISAK 244
                .|:..|                                               :||...|.
  Rat   623 RPLDYEQIPNGLIYLTVMAKDAGNPPLYSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT 687

  Fly   245 SLVINGDD---------ESGVW----------------LVTNRPLDREERAHYDLSVEASD--VD 282
            .|.:|..|         ||.::                :.|...||||.:|.|.|.|.|.|  |.
  Rat   688 VLFLNATDLDRSREYGQESIIYSLEGSSQFRINARSGEITTTSLLDRETKAEYILIVRAVDGGVG 752

  Fly   283 GLDRT-VSKIQITVLDENDNRPIFKSLDYKFAIAGQKSASMESNSSVTYQRFAIMGKVEATDAD- 345
            ...:| ::.:.:|:||.|||.|.:|...|...:.    .....:|.||        .|.|.|.| 
  Rat   753 HNQKTGIATVNVTLLDINDNHPTWKDAPYYINLV----EMTPPDSDVT--------TVVAVDPDL 805

  Fly   346 GDK--IAYRLKSPSNVVIIVPQTGEI-----MLAGE---PTSNELLIEVIAH--DLRYPSLVSAK 398
            |:.  :.|.::.|:....:...||:|     ||..|   |...||:.::|..  |...|.|.:..
  Rat   806 GENGTLVYSIQPPNKFYSLNSTTGKIRTTHVMLDRENPDPVEAELMRKIIVSVTDCGRPPLKATS 870

  Fly   399 PAKVLLEFLAAEPVSFIMQHLEHDDINNHSHHREKRRVTRAVRPT-KRIEFTE--ADGDTEGKSV 460
            .|.|.:..|               |:|::.             || :.:.|..  .:|...|.||
  Rat   871 SATVFVNLL---------------DLNDND-------------PTFQNLPFVAEVLEGTPAGVSV 907

  Fly   461 FQL------EKETDKETFKIRDDNP---WVTVETNGAVRVKKKWDYEELGPEKTIDFWVIITNMG 516
            :|:      |......:::::...|   :|...|:|.|....:.|.|.:...:       :..:.
  Rat   908 YQVVAIDLDEGLNGLVSYRMQVGMPRMDFVINSTSGVVTTTAELDRERIAEYQ-------LRVVA 965

  Fly   517 HNAGI-KYTDNQRVIILVKDVNDEPPYFINRPLPMQAVVQLNAPPNTPVFTLQARDPDTDHN--I 578
            .:||. ..:....:.|.|.|||||.|.|.  |......|..:.|....|..|...|.|...|  :
  Rat   966 SDAGTPTKSSTSTLTIRVLDVNDETPTFF--PAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAEL 1028

  Fly   579 HYFIVRDRTGGRFEVDERSGVVRTRGTDLFQLDME----YVLYVKAEDQNGKVDDRRFQSTPEER 639
            .|||......|:|.|..|..||||    :..||.|    |.|.::|.| ||.|..|| ..|....
  Rat  1029 SYFITAGNVDGKFSVGYRDAVVRT----VVGLDRETTAAYTLVLEAID-NGPVGKRR-TGTATVF 1087

  Fly   640 LSIVG-GKRAPQFYMPSYEAEIPENQKKDSDIISIKAKSFADRE---IRYTLKAQGQGAGTFNIG 700
            ::::. ....|.|...||||.:||:..:...|:.:||....:.|   :.|.: ..|.....|.:.
  Rat  1088 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSIVQLKATDADEGEFGRVWYRI-LHGNHGNNFRLH 1151

  Fly   701 PTSG-IVKLAKELDFEDLRQPHVYSLIVTA-TEDSGGFSTSVDLTIRVTDVNDNAPKFELPDYQA 763
            .:|| :|:..:.|| .:....||  |:..| ..|.|...:||.:.:.|.||||.||.|....|..
  Rat  1152 VSSGLLVRGPRPLD-RERNSSHV--LMAEAYNHDLGPMRSSVRVIVYVEDVNDEAPVFTQQQYNR 1213

  Fly   764 HNVDEDIPLGTSILRVKAMDSDSGSNAEIEYLV---SDDHFAVD-SNGIIVNNKQLDADNNNAYY 824
            ..:.|...:|||::.|:|.|.|:|....:.|.:   ::..|.:| |.|:||....||.:...:|.
  Rat  1214 LGLRETAGIGTSVIVVRATDRDTGDGGLVNYRILSGAEGKFEIDESTGLIVTVDYLDYETKTSYL 1278

  Fly   825 EFIVTAKDKGEPPKSGVATVRVYTKNKNDEEPKFSQQVYTPNVDENAGPNTLVTTVVASDKDGDN 889
             ..|:|.|...|...|..:|.|...|:.||..:||...|...:.||....|.:..|.|...|..|
  Rat  1279 -MNVSATDGAPPFNQGFCSVYVTLLNELDEAVQFSNASYEAVIMENLALGTEIVRVQAYSIDNLN 1342

  Fly   890 ---VRFGFVGGGTSSGQFVIEDITGVIRLHNKAISLDKDK---YELNVTAMDDGSCCVNGDQTIH 948
               .||.......:...|.|:.|||||.:  |.: :|::|   |.|.|.| |||...|:      
  Rat  1343 QITYRFDAYTSAQAKALFKIDAITGVITV--KGL-VDREKGDFYTLTVVA-DDGGPKVD------ 1397

  Fly   949 TSTAVVVVFITDVNDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPN 1013
             ||..|.|.:.|.|||.|.|...|.....|.|..|.|..|..|.|.|.|.|.||||.:|:. ..|
  Rat  1398 -STVKVYVTVLDENDNSPRFDFTSDSAISVPEDCPVGQRVATVKARDPDAGSNGQVVFSLA-SGN 1460

  Fly  1014 QKGT--KFTVDEETGEVSTNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPP 1076
            ..|.  ..|.::..|||...|..|||..|...:.:.  |:|:|.|..:......|.|.|||||||
  Rat  1461 IAGAFEIITSNDSIGEVFVAKPLDREELDHYILKIV--ASDRGTPPRKKDHILQVTILDVNDNPP 1523

  Fly  1077 LFDRQ-KYVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVL 1140
            :.:.. .|..:|.::...||::::|.|:|.|...|..:.|.:|   ..|:...|.:...||.|..
  Rat  1524 VIESPFGYNVSVNENVGGGTSVVQVRATDRDIGINSVLSYYIT---EGNEDMTFRMDRISGEIAT 1585

  Fly  1141 KKPLDGCYPRDR-----YRLRVSASDKGTPASAADVDVELDVVDRNNKPPIWDKSIYGPIHIREN 1200
            :..     |.||     |.|.|:..|:|||..:|...|.:.:||.|:..|::.:..|..:.....
  Rat  1586 RPA-----PPDRERQNFYHLVVTVEDEGTPTLSATTHVYVTIVDENDNAPVFQQPHYEVVLDEGP 1645

  Fly  1201 VTVGTVVTSVKASSGIEG-NPTVFYRLMPGSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYE 1264
            .||.|.:.:|:|....|| |.||.|.::.|     |..:||.:.:|.      ..|.....||||
  Rat  1646 DTVNTSLITVQALDLDEGPNGTVTYAIVAG-----NIINTFRINRRT------GVITAAKELDYE 1699

  Fly  1265 -SIKEYNLTIRVENNG---AQQLASEATVYIMLEDVNDEIPLFTEREQE---TVLEGEPIGTKVT 1322
             |...|.|.:...:..   :.:|.|..||.:.:.|:||.:|.| .|:.|   .|.||:| |.:|.
  Rat  1700 ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTF-PRDYEGPFDVTEGQP-GPRVW 1762

  Fly  1323 QVNAIDKDGTFPNNQVYYYIVD-SPRNEGKEFFEINLQSGEIFTK--TVFDREKKGAYALEVEAR 1384
            ...|.|:| :.||.||.|.:|| .|..|    |.|:...|.:..:  ...|||....|.|.:.||
  Rat  1763 TFLAHDRD-SGPNGQVEYSVVDGDPLGE----FVISPVEGVLRVRKDVELDRETIAFYNLTICAR 1822

  Fly  1385 D-GAPSARPNSNGPNSVTKFIRIGIADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDE- 1447
            | |.|        |.|.|..:.|.:.|.|||.|..........:.||..:...|..|.|.|.|. 
  Rat  1823 DRGVP--------PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSG 1879

  Fly  1448 -SSRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELRLAASDN------LKENYTTVI 1505
             ::.:.:.||:||...||.:...||.:.|...||.|....|.|.::..||      .::::..::
  Rat  1880 CNALLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYRLTVSVKDNPENPRIARKDFDLLL 1944

  Fly  1506 IHVKDVNDNPPVFERPTYRTQITEEDDRNLPKRVLQ--VTATDGDKDRPQNIVYFLTGQGIDPDN 1568
            :.:.|.|||.|:|...||:.::.|......|..||.  :.|.|.|:|....:.|.|.|...|   
  Rat  1945 VSLADENDNHPLFTEGTYQAEVMENSPAGTPLTVLNGPILALDADEDVYAVVTYQLLGTHSD--- 2006

  Fly  1569 PANSKFDINRTTGEIFVLKP--LDRD--QPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDIND 1629
                .|.|:.:||.:.|...  :||:  .|   |.....:.|:|.|  .|.|.|.:.:.:.|.||
  Rat  2007 ----LFVIDNSTGVVTVRSGVIIDREAFSP---PFLELLLLAEDVG--QLNGTAYLFITILDDND 2062

  Fly  1630 NAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEP 1694
            |.|.|....|..::.||...|..|:.:||.|.|   .|.|..|||.||....:.      |.|.|
  Rat  2063 NWPTFSPPAYTVHLLENCPPGFSVLQITATDED---SGLNGELVYRIEAGAQDR------FLIHP 2118

  Fly  1695 DTGVIKTAVCCLDRERTPDYSIQVVAMDGG--GLKGTGTASIRVKDINDMPPQFTKD-EWFTEVD 1756
            .||||:.....:|||....|.:.|||.|.|  .|.||.|.:|.:.||||..|:|... :..:.::
  Rat  2119 VTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTATVTILIDDINDSRPEFLNPIQTVSVLE 2183

  Fly  1757 ETDGTALPEMPILTVTVHDEDETNKFQYKVI------DNSGYGADKFTMVRNNDGTGSLKIVQPL 1815
            .|:    |...|..||..|.|...|.:|.::      |......|:......|..|||:.:..||
  Rat  2184 STE----PGTVIANVTAIDLDLNPKLEYHILSIVAKDDTDRLVPDQEDAFAVNINTGSVIVKSPL 2244

  Fly  1816 DYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEV---SVFED 1877
            :.|  |.:. :...:.|.|...|.......|..:.:.|.:.|:|||.|.|:...:..   .|.|.
  Rat  2245 NRE--LVAT-YEVTLSVIDNASDLPERSVSVPNAKLTVNILDVNDNTPQFKPFGITYYTERVLEG 2306

  Fly  1878 TKVGTELEKFKATDPDQGGKSKVSYS-IDRSSDRQRQFAINQNGSVTIQRSLDREVVPRHQVKIL 1941
            ...||.|....|.|||:|....::|: :|.......|...:..|.|...|::|.|.|......:.
  Rat  2307 ATPGTTLIAVAAVDPDKGLNGLITYTLLDLIPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVR 2371

  Fly  1942 AIDDGSPPKTATATLTVIVQDINDNAPKFLK-DYRPVLPEHVPPRKVV-EILATDDD-------D 1997
            |.|:||||:.|...:.:.:.|||||.|.|.: .|:..:.|.|....|: .:.|||.|       :
  Rat  2372 ASDNGSPPRAAEIPVYLEIVDINDNNPIFDQLSYQEAVFEDVAVGTVILRVTATDADSGNFALIE 2436

  Fly  1998 RSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKDH 2062
            .|..:|.. :|.::|:..||.                   |:|||   |||::..|::..:.||:
  Rat  2437 YSLVDGEG-KFAINPNTGDIY-------------------VLSSL---DREKKDHYILTALAKDN 2478

  Fly  2063 GSPAMTG--TSTLTVIIG--DVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYVYDLDDWDLPDKK 2123
            .....:.  .:::.|:|.  ||||.:.|..........|:.:...|.:..:...|.|:.......
  Rat  2479 PGDVASNRRENSVQVVIRVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMLATDQDEGSNGQLT 2543

  Fly  2124 FYWEAMEHPRFKLDEDSGMVTMRAGTRE-GRYHLRFKVYDRKHTQ-----------TDIPANVTV 2176
            :..|......|.:|.|||:||.:...:. .|::|.....|.....           .|:..|..|
  Rat  2544 YSLEGPGMEAFSVDMDSGLVTTQRPLQSYERFNLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPV 2608

  Fly  2177 TVR-----------EIP-----HEAVVNSGSVRLSGISDEDFI-----RVWNYRTQSMSRSKMDR 2220
            .||           |||     :|.........|:|.....|:     |.|.|.|          
  Rat  2609 FVRPPNGTILHIKEEIPLRSNVYEVYATDKDEGLNGAVRYSFLKSTGNRDWEYFT---------- 2663

  Fly  2221 FRDKLADLLNT----ERENVDIFSVQL 2243
             .|.::.|:.|    :||...::|:.|
  Rat  2664 -IDPISGLIQTAQRLDREKQAVYSLIL 2689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637 41/217 (19%)
Cadherin_repeat 337..396 CDD:206637 20/71 (28%)
E_set 449..541 CDD:298831 22/103 (21%)
Cadherin_repeat 549..>625 CDD:206637 25/81 (31%)
Cadherin_repeat 655..752 CDD:206637 30/101 (30%)
Cadherin_repeat 765..853 CDD:206637 27/91 (30%)
Cadherin_repeat 862..964 CDD:206637 34/107 (32%)
Cadherin_repeat 973..1074 CDD:206637 35/102 (34%)
Cadherin_repeat 1083..1166 CDD:206637 25/87 (29%)
Cadherin_repeat <1219..1298 CDD:206637 22/82 (27%)
Cadherin_repeat 1310..1414 CDD:206637 37/107 (35%)
Cadherin_repeat 1423..1514 CDD:206637 25/98 (26%)
Cadherin_repeat 1522..1630 CDD:206637 31/113 (27%)
Cadherin_repeat 1638..1741 CDD:206637 39/104 (38%)
Cadherin_repeat 1762..1861 CDD:206637 25/104 (24%)
Cadherin_repeat 1871..1966 CDD:206637 29/98 (30%)
Cadherin_repeat 1974..2083 CDD:206637 29/120 (24%)
EGF 2350..2380 CDD:278437
LamG 2385..2570 CDD:238058
EGF_2 <2605..2631 CDD:285248
Laminin_G_2 2665..2800 CDD:280389
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
Cdh23XP_038954289.1 Cadherin_repeat 42..128 CDD:206637
Cadherin_repeat 136..231 CDD:206637
Cadherin_repeat 240..344 CDD:206637
Cadherin_repeat 352..454 CDD:206637 1/8 (13%)
Cadherin_repeat 463..555 CDD:206637 17/94 (18%)
Cadherin_repeat 564..665 CDD:206637 16/111 (14%)
Cadherin_repeat 674..772 CDD:206637 25/97 (26%)
Cadherin_repeat 780..884 CDD:206637 29/130 (22%)
Cadherin_repeat 892..988 CDD:206637 20/102 (20%)
Cadherin_repeat 997..1096 CDD:206637 31/104 (30%)
Cadherin_repeat 1104..1201 CDD:206637 29/100 (29%)
Cadherin_repeat 1216..1306 CDD:206637 27/90 (30%)
Cadherin_repeat 1315..1412 CDD:206637 34/107 (32%)
Cadherin_repeat 1424..1521 CDD:206637 35/99 (35%)
Cadherin_repeat 1531..1628 CDD:206637 31/104 (30%)
Cadherin_repeat 1636..1738 CDD:206637 31/112 (28%)
Cadherin_repeat 1750..1845 CDD:206637 37/108 (34%)
Cadherin_repeat 1853..1953 CDD:206637 25/99 (25%)
Cadherin_repeat 1961..2063 CDD:206637 31/113 (27%)
Cadherin_repeat 2072..2167 CDD:206637 39/103 (38%)
Cadherin_repeat 2178..2287 CDD:206637 26/115 (23%)
Cadherin_repeat 2299..2396 CDD:206637 29/96 (30%)
Cadherin_repeat 2404..2502 CDD:206637 28/120 (23%)
Cadherin_repeat 2511..2605 CDD:206637 16/93 (17%)
Cadherin_repeat 2618..2716 CDD:206637 18/83 (22%)
Cadherin_repeat 2733..2839 CDD:206637
Cadherin_repeat 2848..2949 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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