DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and CDH15

DIOPT Version :10

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_004924.1 Gene:CDH15 / 1013 HGNCID:1754 Length:814 Species:Homo sapiens


Alignment Length:1631 Identity:283/1631 - (17%)
Similarity:417/1631 - (25%) Gaps:956/1631 - (58%)


- Green bases have known domain annotations that are detailed below.


  Fly  1515 PPVFERPTYRTQITEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRT 1579
            ||:         ...|:.:.||..::|:.:   ||.:..:::|.:.|.|:|.:  ....|.|::.
Human    50 PPI---------SVSENHKRLPYPLVQIKS---DKQQLGSVIYSIQGPGVDEE--PRGVFSIDKF 100

  Fly  1580 TGEIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVT 1644
            ||::|:...|||::.:   ::|...||.|.||..|....|:::.:.|.|||.|.|.|..:.|.|.
Human   101 TGKVFLNAMLDREKTD---RFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVL 162

  Fly  1645 ENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSP-IFEIEPDTGVIKTAVCCLDR 1708
            |....|..|....|.|.||| |..||.|.:||      .:.||| :|.|:..||.|:|....|||
Human   163 EGAVPGTYVTRAEATDADDP-ETDNAALRFSI------LQQGSPELFSIDELTGEIRTVQVGLDR 220

  Fly  1709 ERTPDY--SIQVVAMDGGGLKGTGTASIRVKDINDMPPQFTKDEWFTE-------VD----ETDG 1760
            |....|  ::||..|.|.||..|.:|.|.:.||||..|:||:||:|.|       ||    |.:.
Human   221 EVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVED 285

  Fly  1761 TALPEMP--ILTVTVHDEDETNKFQYKVIDNSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQS 1823
            ..||..|  :...|:.:.|...:|..:            |..:.|:|.  |.||:.||||   ..
Human   286 RDLPGSPNWVARFTILEGDPDGQFTIR------------TDPKTNEGV--LSIVKALDYE---SC 333

  Fly  1824 NGFRFRIQVN------------DKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFE 1876
            ..:..::.|.            ::|:           :.|.|.::|.|: .|.|:...:..|:.|
Human   334 EHYELKVSVQNEAPLQAAALRAERGQ-----------AKVRVHVQDTNE-PPVFQENPLRTSLAE 386

  Fly  1877 DTKVGTELEKFKATDPDQGGKSKVSYS----------IDRSSDRQRQFAINQNGSVTIQRSLDRE 1931
            ....||.:..|.|.|||.....::|||          :|.::.|.:...:....|..::....|.
Human   387 GAPPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRA 451

  Fly  1932 VVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEILATDDD 1996
            :|       ||.||.|.|:|||.||::.:.::||:||                     :||    
Human   452 IV-------LAQDDASQPRTATGTLSIEILEVNDHAP---------------------VLA---- 484

  Fly  1997 DRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKD 2061
                   ||                                                        
Human   485 -------PP-------------------------------------------------------- 486

  Fly  2062 HGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYVYDLDDWDLPDKKFYW 2126
                                    .|||                                     
Human   487 ------------------------PPGS------------------------------------- 490

  Fly  2127 EAMEHPRFKLDEDSGMVTMRAGTREGRYHLRFKVYDRKHTQTDIPANVTVTVREIPHEAVVNSGS 2191
                                                               :...||:     |.
Human   491 ---------------------------------------------------LCSEPHQ-----GP 499

  Fly  2192 VRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDKLADLLNTERENVDIFSVQLKRKHPPLTDVRFS 2256
            ..|.|.:|||.                                             ||       
Human   500 GLLLGATDEDL---------------------------------------------PP------- 512

  Fly  2257 AHGSPYYKPVRLNGIVLMHREEIEKDVGINITMVGIDECLYENQMCEGSCTNSLEISP-LPYMVN 2320
             ||:|::                                              .::|| ||.:  
Human   513 -HGAPFH----------------------------------------------FQLSPRLPEL-- 528

  Fly  2321 ANKTALVGVRVDTIADCTCGARNFTKPESCRTTPCHNGGRCVDTRFGPHCSCPVGYTGPRCQQTT 2385
                                                                             
Human   529 ----------------------------------------------------------------- 528

  Fly  2386 RSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPR 2450
                |..|:    |...:.||..|....:.|:||                               
Human   529 ----GRNWS----LSQVNVSHARLRPRHQVPEGL------------------------------- 554

  Fly  2451 LLIDFGSGTLELRVKTKKTLDDGEWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSC 2515
                                     ||:.|.     :|              :.|.||       
Human   555 -------------------------HRLSLL-----LR--------------DSGQPP------- 568

  Fly  2516 QARGQIPPFNEYLNVNAPLQVGGLYREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAHPG 2580
            |.|.|            ||.|                                            
Human   569 QQREQ------------PLNV-------------------------------------------- 577

  Fly  2581 LSRNSVAGCPQTEEVCAQTETTARCWEHGNCVGSLSEARCHCRPGWTGPACNIPTIPTTFKAQSY 2645
                                |..||.:.|.|:           ||                    
Human   578 --------------------TVCRCGKDGVCL-----------PG-------------------- 591

  Fly  2646 VKYALSFEPDRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSLRTEEKD 2710
                                                                             
Human   592 ----------------------------------------------------------------- 591

  Fly  2711 LWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAEY 2775
                                   ||.| |.||.|                               
Human   592 -----------------------AAAL-LAGGTG------------------------------- 601

  Fly  2776 TGVRTFEVYADYQKSCLDDIRLEGKHLPLPPAMNGTQWGQATMARNLEKGCPSNKPCSNVICPDP 2840
                                                                             
Human   602 ----------------------------------------------------------------- 601

  Fly  2841 FECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPCMNGATCINLEPRLRYRCICPDGFWGEN 2905
                                                                             
Human   602 ----------------------------------------------------------------- 601

  Fly  2906 CELVQEGQTLKLSMGALAAILVCLLIILILVLVFVV----YNRRREAHIKYPGPDDDVRENIINY 2966
                       ||:|||..:|...|::|:|||:..:    :.:.|...:.: ||.||:|:|::||
Human   602 -----------LSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLH-GPQDDLRDNVLNY 654

  Fly  2967 DDEGGGEDDMTAFDI------TPLQIPIGGPMPPEL---APM-----KMPIMYPVMTLMPGQEPN 3017
            |::||||:|..|:||      |.|.:|:|   ||.|   ||.     :.|.:.|...|      :
Human   655 DEQGGGEEDQDAYDISQLRHPTALSLPLG---PPPLRRDAPQGRLHPQPPRVLPTSPL------D 710

  Fly  3018 VGMFIEEHKKRADGDPNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGPRFDK 3082
            :..||.:..:.||.||:.||:|....|.|||.||.||:|||:.|...||.|:||||..|||||.:
Human   711 IADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFAR 775

  Fly  3083 LANMYG 3088
            ||:|||
Human   776 LADMYG 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
CA_like 449..541 CDD:481204
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637
Cadherin_repeat 1083..1166 CDD:206637
Cadherin_repeat <1219..1298 CDD:206637
Cadherin_repeat 1310..1414 CDD:206637
Cadherin_repeat 1423..1514 CDD:206637
Cadherin_repeat 1522..1630 CDD:206637 28/107 (26%)
Cadherin_repeat 1638..1741 CDD:206637 41/105 (39%)
CA 1770..1863 CDD:214520 19/104 (18%)
Cadherin_repeat 1871..1966 CDD:206637 29/104 (28%)
Cadherin_repeat 1974..2083 CDD:206637 4/108 (4%)
EGF 2350..2380 CDD:394967 0/29 (0%)
LamG 2385..2570 CDD:238058 22/184 (12%)
EGF_2 2605..2631 CDD:400365 5/25 (20%)
LamG 2637..2797 CDD:238058 7/159 (4%)
EGF_CA 2869..2907 CDD:238011 0/37 (0%)
CADH_Y-type_LIR 3029..3088 CDD:460041 34/58 (59%)
CDH15NP_004924.1 Cadherin_repeat 52..148 CDD:206637 28/112 (25%)
Cadherin_repeat 157..256 CDD:206637 42/105 (40%)
Cadherin_repeat 271..371 CDD:206637 24/127 (19%)
Cadherin_repeat 379..479 CDD:206637 29/106 (27%)
CA_like 487..580 CDD:481204 43/517 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 636..663 13/27 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 676..703 10/29 (34%)
CADH_Y-type_LIR 722..781 CDD:460041 34/58 (59%)
Blue background indicates that the domain is not in the aligned region.

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