DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and CDH13

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001207417.1	Gene:	CDH13 / 1012	HGNCID:	1753	Length:	760	Species:	Homo sapiens

Alignment Length:	758	Identity:	227/758 - (29%)
Similarity:	349/758 - (46%)	Gaps:	130/758 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1392 PNSNGPN---------SVTKFIRIGIADKNDNPPYFDKSLYE----AEVDENEDIQHTVLTVTAK 1443
            |:.|||.         |..:.:.:..|:..|..|.|.:.::.    ||..|::    ::|.:|..
Human    43 PSENGPQMPGRDPPAASTMQVLLLTSAEDLDCTPGFQQKVFHINQPAEFIEDQ----SILNLTFS 103

  Fly  1444 DHDESSRIRYEITS-----GNIGGAFAVKNMTG---AIYVAGALDYETRRRYELRLAASDNLKEN 1500
            |...:.::|||::|     .:.||..|::|:|.   .::|            ..|...::::.|
Human   104 DCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGKTLFV------------HARTPHAEDMAE- 155

  Fly  1501 YTTVIIHVKDVNDN-PPVFE----RPTYRTQ---------ITEEDDRNLPKRVLQVTATDGDKDR 1551
              .||:..||:..: ..:|:    .|..|.:         |.|...:..|:.|.:|.    |.||
Human   156 --LVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVV----DSDR 214

  Fly  1552 PQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVG 1616
            |:...:.|||:|:|.:  ....|.||..||.:.|.:.|||:.   ...::..|...|..|:.|.|
Human   215 PERSKFRLTGKGVDQE--PKGIFRINENTGSVSVTRTLDREV---IAVYQLFVETTDVNGKTLEG 274

  Fly  1617 YADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVI 1681
            ...::|.:.|.|||.|||.:|.|.|:|.|....|..||.|||.|.||| ...||.|.|:|.:...
Human   275 PVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDP-ATDNALLRYNIRQQTP 338

  Fly  1682 EEETGSP-IFEIEPDTGVIKTAV--CCLDRE--RTPDYSIQVVAMDGG----GLKGTGTASIRVK 1737
            ::.  || :|.|:|:.|.|.|.|  ..||||  ..|.|.:.:.|.|..    ||.||.||:|.:.
Human   339 DKP--SPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMID 401

  Fly  1738 DINDMPPQFTKDEWFTEVDE-TDGTALPEMPILTVTVHDEDETN----KFQYKVID-NSGYGADK 1796
            |.||..|:|||.|:...|:| ..|.      |:.:||.|:|:..    :..|.:|: |.|...:.
Human   402 DKNDHSPKFTKKEFQATVEEGAVGV------IVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEI 460

  Fly  1797 FTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAY-----SWVVVKLR 1856
            .|..:.|:  |.|.:|:|||||    .:.|...:   .|.|:.|.....|:|     :.|.:.:.
Human   461 HTNPQTNE--GMLSVVKPLDYE----ISAFHTLL---IKVENEDPLVPDVSYGPSSTATVHITVL 516

  Fly  1857 DINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQ-NG 1920
            |:|:. |.|....:.|:..||..||:.|....|||||......:.||:.:  |......||. ||
Human   517 DVNEG-PVFYPDPMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYK--DPAGWLNINPING 578

  Fly  1921 SVTIQRSLDRE--VVPR--HQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEH 1981
            :|.....||||  .|..  :....||||.|:||.|.|.||.:.::|:||||| |:   .|.:.|.
Human   579 TVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAP-FI---YPTVAEV 639

  Fly  1982 VPPRK--VVEILATDDDDRSKSNGPPFQFRLDPSA--DDIIRASFKVEQDQKGANGDGMAVISSL 2042
            ....|  .|.||...|.| ...|..||:|.:...|  |.:.:.| |:....        |::|.|
Human   640 CDDAKNLSVVILGASDKD-LHPNTDPFKFEIHKQAVPDKVWKIS-KINNTH--------ALVSLL 694

  Fly  2043 RSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKM 2085
            ::.::   ..|.:||::.|.|.|.||..:.|.|.:....::|:
Human   695 QNLNK---ANYNLPIMVTDSGKPPMTNITDLRVQVCSCRNSKV 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637	6/30 (20%)
		Cadherin_repeat	1423..1514	CDD:206637	22/102 (22%)
		Cadherin_repeat	1522..1630	CDD:206637	32/116 (28%)
		Cadherin_repeat	1638..1741	CDD:206637	44/111 (40%)
		Cadherin_repeat	1762..1861	CDD:206637	28/108 (26%)
		Cadherin_repeat	1871..1966	CDD:206637	37/99 (37%)
		Cadherin_repeat	1974..2083	CDD:206637	29/112 (26%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
CDH13	NP_001207417.1	Cadherin_pro	74..159	CDD:285913	21/103 (20%)
		CA	208..290	CDD:214520	29/90 (32%)
		Cadherin_repeat	296..406	CDD:206637	45/112 (40%)
		Cadherin	415..516	CDD:278457	29/115 (25%)
		Cadherin_repeat	535..628	CDD:206637	36/94 (38%)
		E_set	636..727	CDD:298831	28/103 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910