DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and CDH12

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_001304156.1	Gene:	CDH12 / 1010	HGNCID:	1751	Length:	794	Species:	Homo sapiens

Alignment Length:	546	Identity:	170/546 - (31%)
Similarity:	276/546 - (50%)	Gaps:	57/546 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1548 DKDRPQNIV-YFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQD-EG 1610
            |.|:.:..| |.|:|.|      |.:.|.|:.|||:|..::.|||::   :|.:.....|.| |.
Human    81 DLDKGEGTVKYTLSGDG------AGTVFTIDETTGDIHAIRSLDREE---KPFYTLRAQAVDIET 136

  Fly  1611 GEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYS 1675
            .:.|...::..:.::|||||.|.|..|.|...|.|....|..|:.:.|.|.|||..|::||:|||
Human   137 RKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYS 201

  Fly  1676 IEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDG----GGLKGTGTASIRV 1736
            |.:       |.|.|.|:|.||||:||:..:|||....|.:.:.|.|.    |||.||...:|.:
Human   202 ILQ-------GQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITL 259

  Fly  1737 KDINDMPPQFTKDEWFTEVDETD--GTALPEMPILTVTVHDED--ETNKFQYKVIDNSGYGADKF 1797
            .|:||.||:|.|..:..:|.|:.  |:|:..     :...|.|  :..:.:|.::  .|.|.:.|
Human   260 TDVNDNPPRFPKSIFHLKVPESSPIGSAIGR-----IRAVDPDFGQNAEIEYNIV--PGDGGNLF 317

  Fly  1798 TMVRNND-GTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVA-----YSWVVVKLR 1856
            .:|.:.| ..|.:|:.:|||:|.:   ..:.|:::.::...|:   ::|.|     .:.|.:.:.
Human   318 DIVTDEDTQEGVIKLKKPLDFETK---KAYTFKVEASNLHLDH---RFHSAGPFKDTATVKISVL 376

  Fly  1857 DINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQN-G 1920
            |: |..|.|.:....:.|:|||.|||.:....|.|.|. |.|.|.|.||..||....|.|:.| |
Human   377 DV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDV-GSSAVRYFIDWKSDGDSYFTIDGNEG 439

  Fly  1921 SVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPR 1985
            ::.....||||...::...|:|....:|..|:...:.:.|.|:|:..|:....|...:.|:..|.
Human   440 TIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPG 504

  Fly  1986 KVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRS-FDREQ 2049
            ::::|::..|.|.|.: |..|.|||.|.|  .|:.:|.|...:....|     |.:.|: :.|.|
Human   505 QIIQIVSAADRDLSPA-GQQFSFRLSPEA--AIKPNFTVRDFRNNTAG-----IETRRNGYSRRQ 561

  Fly  2050 QKEYMIPIVIKDHGSPAMTGTSTLTV 2075
            |:.|.:|:||:|...|..:.|:|:|:
Human   562 QELYFLPVVIEDSSYPVQSSTNTMTI 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	25/83 (30%)
		Cadherin_repeat	1638..1741	CDD:206637	41/106 (39%)
		Cadherin_repeat	1762..1861	CDD:206637	21/106 (20%)
		Cadherin_repeat	1871..1966	CDD:206637	33/95 (35%)
		Cadherin_repeat	1974..2083	CDD:206637	32/103 (31%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
CDH12	NP_001304156.1	CA	80..158	CDD:214520	27/85 (32%)
		Cadherin_repeat	164..265	CDD:206637	42/107 (39%)
		Cadherin_repeat	273..380	CDD:206637	24/120 (20%)
		Cadherin_repeat	389..484	CDD:206637	32/95 (34%)
		Cadherin_repeat	492..590	CDD:206637	32/104 (31%)
		Cadherin_C	638..785	CDD:307269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5199
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910