DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and cntnap4

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_031746836.1	Gene:	cntnap4 / 100498435	XenbaseID:	XB-GENE-6052455	Length:	1313	Species:	Xenopus tropicalis

Alignment Length:	534	Identity:	116/534 - (21%)
Similarity:	182/534 - (34%)	Gaps:	166/534 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  2313 SPLPY-----MVNANKTALVGVRVDTIADCTCGARNFTKPESCRTTPCHNGGRCVDTRFGPHCSC 2372
            |.:||     ..|..:|...|...| ::.||||...                .|:|::.  :|:|
Frog   697 SHIPYSWWVGRTNETQTYWSGSSPD-VSKCTCGIEE----------------NCIDSQL--YCNC 742

  Fly  2373 ------------------------------------------PVGYTGPRCQQTTRSFRG-NGWA 2394
                                                      |:...|.|....:.||.. :.:.
Frog   743 DADKSEWSNDTGFLSYKDHLPVTKIVITDTDRPQSEAAYKLGPLLCWGDRSFWNSASFNTVSSYL 807

  Fly  2395 WYPPLEMCDESHLSLEFITRKPDGLIIYN-GPIVPPERDETLISDFIALELERGYPRLLI---DF 2455
            .:|.|.....:.:|..|.|..|.||.:.| |           |.|||.:||:.  |..::   |.
Frog   808 HFPTLHGEISADVSFFFKTSSPSGLFLENLG-----------IKDFIRIELQS--PTEVVFSFDV 859

  Fly  2456 GSGTLELRVKTKKTLDDGEWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQ 2520
            |:|...:.|::...|:|.:||.|....:.:...:.||......|....||
Frog   860 GNGPFGVTVQSPSNLNDNQWHFIKAERNIKEASLQVDQLPQKTIITPSDG--------------- 909

  Fly  2521 IPPFNEYLNVNAPLQVGGLYREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAH-----PG 2580
                :..|.:|:.|.:||....|              |||.||||.|..|....||..     ||
Frog   910 ----HIRLQLNSQLYIGGTASRQ--------------KGFLGCIRYLTLNGIALDLEERAKVTPG 956

  Fly  2581 LSRNSVAGCPQTEEVCAQTETTARCWEHGNCV---GSLSEAR----CHCR-PGWTGPACN----- 2632
            :.    .|||            ..|..:||..   |...|..    |.|. ..:.||.|.
Frog   957 IK----PGCP------------GHCSSYGNLCHNGGKCEEKHNGFLCDCNSSAYGGPFCKKEISA 1005

  Fly  2633 --------IPTIPTTFK-AQSYVKYALSFEPDRFSTQ-VQLRFRTREEYGELFRVSDQHNREYGI 2687
                    ..|.|..:. :::...|:.:..||..|.: :...|||.:....|..||..:.:...|
Frog  1006 YFGGGSSATLTFPENYTISRNASWYSSAQHPDTNSRENIAFSFRTTQSPSLLLFVSSFNKQYISI 1070

  Fly  2688 LEIKDGHLHFRYNLNSLRTEEKDLW-LNAIVVNDGQWHVVKVNRYGSAATLELDGGEGRRYNET- 2750
            :..|:|.|..||.|.  ...:.|:: :|...:.||....|::.|.|....:|::.....:::.|
Frog  1071 IIAKNGSLQIRYKLE--HHLDPDVFNINTKNLVDGHLQKVRILRKGETLFIEVNQYTAVKFSLTS 1133

  Fly  2751 -FEFVGHQWLLVDK 2763
             .||...|:|::.|
Frog  1134 VTEFKAVQFLILGK 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	6/71 (8%)
		LamG	2385..2570	CDD:238058	47/189 (25%)
		EGF_2	<2605..2631	CDD:285248	9/33 (27%)
		Laminin_G_2	2665..2800	CDD:280389	27/102 (26%)
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
cntnap4	XP_031746836.1	FA58C	36..180	CDD:238014
		Laminin_G_2	216..345	CDD:396680
		Laminin_G_2	401..527	CDD:396680
		EGF_CA	553..588	CDD:238011
		COLFI	607..>690	CDD:413320
		Laminin_G_2	824..943	CDD:396680	43/164 (26%)
		EGF_CA	965..1000	CDD:238011	9/34 (26%)
		Laminin_G_2	1048..1179	CDD:396680	27/102 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910