DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and cdh9

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_017950449.1	Gene:	cdh9 / 100495910	XenbaseID:	XB-GENE-6039319	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	552	Identity:	171/552 - (30%)
Similarity:	286/552 - (51%)	Gaps:	65/552 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1545 TDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQD- 1608
            ||.||.. .|:.|.|:|.|      |.|.|.|:..||:|...|.|||::   :..:.....|.|
Frog    82 TDHDKGE-GNLKYILSGDG------AGSVFIIDENTGDIQAAKRLDREE---KSMYVLRAMAIDR 136

  Fly  1609 EGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLV 1673
            :.|:.:...:...:.:.|||||.|.|.:.||:.:|.|....|..|:.:||:|.|||:.|::|::|
Frog   137 KTGKQVEPESQFVIKIHDINDNEPKFTKDVYYASVPEMSEVGTSVIQVTALDNDDPSYGNSAKIV 201

  Fly  1674 YSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASI 1734
            |||.:       |.|.|.|:|::|:||||:..::||....|.:.:.|.|    .|||.||.|.:|
Frog   202 YSIIQ-------GQPYFSIDPESGIIKTALPDMNRENREHYQVVIQAKDMGGQMGGLSGTTTVNI 259

  Fly  1735 RVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDED--ETNKFQYKVIDNSGYGADKF 1797
            .:.|:||.||:|.:..:  :...|:..|:.: .|..:..:|||  :..:..||:||....|  .|
Frog   260 TLTDVNDNPPRFPQSIY--QFSSTESAAIGK-AIGRIKANDEDMGKNAEIHYKIIDGDEEG--HF 319

  Fly  1798 TMVRNND-GTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDK---YHVA----YSWVVVK 1854
            .::.:.: ..|.:.:.:.||:|.:        |:...:....|.|.:   :|:.    .:.|.|.
Frog   320 DIITDQETQEGIITVKKLLDFESR--------RLHTFEVEASNMNVEPRFFHLGPFKDTATVKVV 376

  Fly  1855 LRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAI-NQ 1918
            |:|. |..|.|.::...:.|.||.|.|..:.:..|.||| ..|:.|.|||||::|.::.|:| :.
Frog   377 LQDA-DEAPVFSKSFYVIEVDEDAKEGNIVGQVTAQDPD-SSKNPVRYSIDRNTDIEKMFSIYSG 439

  Fly  1919 NGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVP 1983
            |||:.:::|||||.:|.|.:.::|.:..:|..:.:..:...:.||||:||:|.|.|...:.|:..
Frog   440 NGSIFLEKSLDREEIPWHNITVIATEANNPKLSRSVHVYFKILDINDHAPEFAKHYETFVCENAK 504

  Fly  1984 PRKVVEILATDDDDRSKSNGPP----FQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRS 2044
            ..::::.::..|.|.     ||    |.|.:.|  |..|..:|.|..     |.|..|.|.:.|:
Frog   505 QGQLIQTVSAIDKDE-----PPRGHRFYFEMVP--DFSINPNFTVLD-----NKDNTASIFTKRN 557

  Fly  2045 -FDREQQKEYMIPIVIKDHGSPAMTGTSTLTV 2075
             ::|.:...|::||:|.|:..|..:.|.|||:
Frog   558 GYNRHKISTYVLPIIIFDNDYPVQSSTETLTI 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	26/85 (31%)
		Cadherin_repeat	1638..1741	CDD:206637	41/106 (39%)
		Cadherin_repeat	1762..1861	CDD:206637	23/108 (21%)
		Cadherin_repeat	1871..1966	CDD:206637	34/95 (36%)
		Cadherin_repeat	1974..2083	CDD:206637	29/107 (27%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
cdh9	XP_017950449.1	CA	82..160	CDD:214520	28/87 (32%)
		Cadherin_repeat	166..267	CDD:206637	42/107 (39%)
		Cadherin_repeat	275..382	CDD:206637	24/120 (20%)
		Cadherin_repeat	391..487	CDD:206637	34/96 (35%)
		Cadherin_repeat	494..592	CDD:206637	29/108 (27%)
		Cadherin_C	640..790	CDD:366437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9756
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910