DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and cdh19

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_031760338.1	Gene:	cdh19 / 100493723	XenbaseID:	XB-GENE-6045915	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	598	Identity:	167/598 - (27%)
Similarity:	280/598 - (46%)	Gaps:	67/598 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1521 PTYRTQITEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFV 1585
            |.|   :.||.:...|..:.|: .:|.|| :..:..|.|.|.|      |.:.|.|:..||:|::
Frog    50 PFY---VLEEQEITEPLYIGQL-KSDLDK-QDGSFKYILLGDG------AKTIFTIDERTGKIYL 103

  Fly  1586 LKPLDRDQPNGRPQWRFTVFAQ---DEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENG 1647
            ||.|||::.:.     :|:.||   ...|..:...::..|.::|||||.|.|....||..|.|..
Frog   104 LKKLDREEKSS-----YTLRAQAINTVTGVPVEAESEFIVKVQDINDNEPKFINEPYFATVPEMS 163

  Fly  1648 TAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTP 1712
            ..|..|..:||.|.||||.|::|||||||.:       |.|.|.|||.:|:|: .|..:|||...
Frog   164 PEGTFVTQVTATDMDDPNYGNSARLVYSILQ-------GQPHFSIEPKSGIIR-VVSQMDREAKD 220

  Fly  1713 DYSIQVVAMD----GGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTV 1773
            .|.:.:.|.|    .|||..|.|.::.:.|:||..|:|.:..:...:.||....    .|:.:.:
Frog   221 LYFVVIQAKDMAGSVGGLSTTTTVTVSLSDVNDNAPKFQQKIYDMSILETSLVG----EIVGMVM 281

  Fly  1774 HDEDETNK---FQYKVIDNSGYGADKFTMVRNN-DGTGSLKIVQPLDYEDQLQSNGFRFRIQVND 1834
            .|:.:..|   ..||:.:...:..  |.::.:| ...|.:.:.:.||||.:.:   :..|::..:
Frog   282 ADDRDIGKNAEMTYKIEEKGDFSI--FDIITDNLTQEGIIILRKTLDYESKKR---YSIRVKAIN 341

  Fly  1835 KGEDNDNDKYHVAYSWVVVKL--RDINDN-----KPHFERANVEVSVFEDTKVGTELEKFKATDP 1892
            |..|....|:.:......||:  .||::.     |.:|      :.:.|:...|:.:....|.||
Frog   342 KHIDERFLKHGLFEDTTTVKIHVEDIDEPAVFGLKEYF------MEILENAPTGSYVGSVTAKDP 400

  Fly  1893 DQGGKSKVSYSIDRSSDRQRQFAINQNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLT 1957
            | ...:.|.|.:.:|......:.....|::|..:.||||....:.|.:.|.:..:....:...:.
Frog   401 D-NINTPVRYGLHQSKHVGLFYIDLHLGAITTTKPLDREEALWYNVTVTATEATNSAHVSEVPVY 464

  Fly  1958 VIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASF 2022
            :.:.|:|||||:..::||..:.|...||:.::|::..|.|.:.: |..|.|.|.|.|.:  ..:|
Frog   465 IRIIDVNDNAPQLSEEYRIYVCEQSKPREPIQIISAVDRDEATA-GQQFSFTLLPEASN--NTNF 526

  Fly  2023 KVEQDQKGANGDGMAVISSLR-SFDREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQ 2086
            .|..     |.|..|.|.:|| .|:..:...:...|||.|:|.|.::.|:|||:.:.|...:...
Frog   527 TVRD-----NKDNTATIYALRDEFNLHETPHFYFEIVINDNGIPPLSSTNTLTIHVCDCGVDGNT 586

  Fly  2087 PGSKDIFVYNYQG 2099
            ...||..::.|.|
Frog   587 EFCKDNGMFLYLG 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	31/110 (28%)
		Cadherin_repeat	1638..1741	CDD:206637	42/106 (40%)
		Cadherin_repeat	1762..1861	CDD:206637	20/104 (19%)
		Cadherin_repeat	1871..1966	CDD:206637	19/94 (20%)
		Cadherin_repeat	1974..2083	CDD:206637	34/109 (31%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
cdh19	XP_031760338.1	Cadherin_repeat	51..146	CDD:206637	31/110 (28%)
		Cadherin_repeat	154..>233	CDD:206637	36/86 (42%)
		Cadherin_repeat	262..369	CDD:206637	22/115 (19%)
		Cadherin_repeat	377..473	CDD:206637	20/102 (20%)
		CA	499..580	CDD:214520	27/88 (31%)
		Cadherin_C	627..760	CDD:395833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9756
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000